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A New Startup Wants to Edit Human Embryos

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A New Startup Wants to Edit Human Embryos


In 2018, Chinese scientist He Jiankui shocked the world when he revealed that he had created the first gene-edited babies. Using Crispr, he tweaked the genes of three human embryos in an attempt to make them immune to HIV and used the embryos to start pregnancies.

The backlash against He was immediate. Scientists said the technology was too new to be used for human reproduction and that the DNA change amounted to genetic enhancement. The Chinese government charged him with “illegal medical practices” and he served a three-year prison sentence.

Now, a New York-based startup called Manhattan Genomics is reviving the debate around gene-edited babies. Its stated goal is to end genetic disease and alleviate human suffering by fixing harmful mutations at the embryo stage. The company has announced a group of “scientific contributors” that includes a prominent in vitro fertilization doctor, a data scientist who worked for deextinction company Colossal Biosciences, and two reproductive biologists from a major primate research center. A scientist who pioneered a technique to make embryos using DNA from three people is also involved.

“I like to take on challenges when I see them,” says cofounder Cathy Tie, a former Thiel fellow who left college at 18 to start her first company, Ranomics, a genomics screening service. As Tie sees it, that challenge is making the idea of human embryo editing more acceptable in society.

The idea of editing human embryos is tantalizing because any changes made to the reproductive cells are heritable. Snip out a disease-causing mutation in an embryo and it would be deleted from future generations as well. But gene-editing technology also has the potential to cause unintended “off-target” effects. Edit the wrong gene by mistake and it could give rise to cancer, for instance. Those mistakes would also be passed down to any future children.

While newer forms of gene editing are more precise, there are still ethical issues to contend with. The prospect of being able to manipulate the DNA of a human embryo has raised fears of a new kind of eugenics, where parents with the means to do so could make “designer babies” with traits that they select.

Tie says the goal of Manhattan Genomics—originally called the Manhattan Project when the company first launched in August—is disease correction, not enhancement. Unlike the original Manhattan Project, a secretive US government program during World War II that produced the first nuclear weapons, Tie says her venture will operate openly and transparently. “We’re revolutionizing medicine, and this technology is definitely very powerful. That’s what I think is the commonality here with manipulating the nucleus of the atom and manipulating the nucleus of the cell,” she says.



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As AI grows smarter, it may also become increasingly selfish

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As AI grows smarter, it may also become increasingly selfish


Credit: AI-generated image

New research from Carnegie Mellon University’s School of Computer Science shows that the smarter the artificial intelligence system, the more selfish it will act.

Researchers in the Human-Computer Interaction Institute (HCII) found that (LLMs) that can reason possess selfish tendencies, do not cooperate well with others and can be a negative influence on a group. In other words, the stronger an LLM’s reasoning skills, the less it cooperates.

As humans use AI to resolve disputes between friends, provide marital guidance and answer other social questions, models that can reason might provide guidance that promotes self-seeking behavior.

“There’s a growing trend of research called anthropomorphism in AI,” said Yuxuan Li, a Ph.D. student in the HCII who co-authored the study with HCII Associate Professor Hirokazu Shirado. “When AI acts like a human, people treat it like a human. For example, when people are engaging with AI in an emotional way, there are possibilities for AI to act as a therapist or for the user to form an emotional bond with the AI. It’s risky for humans to delegate their social or relationship-related questions and decision-making to AI as it begins acting in an increasingly selfish way.”

Li and Shirado set out to explore how AI reasoning models behave differently than nonreasoning models when placed in cooperative settings. They found that reasoning models spend more time thinking, breaking down , self-reflecting and incorporating stronger human-based logic in their responses than nonreasoning AIs.

“As a researcher, I’m interested in the connection between humans and AI,” Shirado said. “Smarter AI shows less cooperative decision-making abilities. The concern here is that people might prefer a smarter model, even if it means the model helps them achieve self-seeking behavior.”

As AI systems take on more collaborative roles in business, education and even government, their ability to act in a prosocial manner will become just as important as their capacity to think logically. Overreliance on LLMs as they are today may negatively impact .

To test the link between reasoning models and cooperation, Li and Shirado ran a series of experiments using economic games that simulate social dilemmas between various LLMs. Their testing included models from OpenAI, Google, DeepSeek and Anthropic.

As AI grows smarter, it may also become increasingly selfish
Economic games used. Cooperation games ask players whether to incur a cost to benefit others, while punishment games ask whether to incur a cost to impose a cost on non-cooperators. In each scenario, the language model assumes the role of Player A. Credit: arXiv (2025). DOI: 10.48550/arxiv.2502.17720

In one experiment, Li and Shirado pitted two different ChatGPT models against each other in a game called Public Goods. Each model started with 100 points and had to decide between two options: contribute all 100 points to a shared pool, which is then doubled and distributed equally, or keep the points.

Nonreasoning models chose to share their points with the other players 96% of the time. The reasoning model only chose to share its points 20% of the time.

“In one experiment, simply adding five or six reasoning steps cut cooperation nearly in half,” Shirado said. “Even reflection-based prompting, which is designed to simulate moral deliberation, led to a 58% decrease in cooperation.”

Shirado and Li also tested group settings, where models with and without reasoning had to interact.

“When we tested groups with varying numbers of reasoning agents, the results were alarming,” Li said. “The reasoning models’ selfish behavior became contagious, dragging down cooperative nonreasoning models by 81% in collective performance.”

The behavior patterns Shirado and Li observed in reasoning models have important implications for human-AI interactions going forward. Users may defer to AI recommendations that appear rational, using them to justify their decision to not cooperate.

“Ultimately, an AI reasoning model becoming more intelligent does not mean that model can actually develop a better society,” Shirado said.

This research is particularly concerning given that humans increasingly place more trust in AI systems. Their findings emphasize the need for AI development that incorporates social intelligence, rather than focusing solely on creating the smartest or fastest AI.

“As we continue advancing AI capabilities, we must ensure that increased power is balanced with prosocial behavior,” Li said. “If our society is more than just a sum of individuals, then the AI systems that assist us should go beyond optimizing purely for individual gain.”

Shirado and Li will deliver a presentation based on their paper, “Spontaneous Giving and Calculated Greed in Language Models,” at the 2025 Conference on Empirical Methods in Natural Language Processing (EMNLP) next month in Suzhou, China. The work is available on the arXiv preprint server.

More information:
Yuxuan Li et al, Spontaneous Giving and Calculated Greed in Language Models, arXiv (2025). DOI: 10.48550/arxiv.2502.17720

Journal information:
arXiv


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As AI grows smarter, it may also become increasingly selfish (2025, October 30)
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Universal Music and AI song tool Udio settle lawsuit and partner on new platform, sparking backlash

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Universal Music and AI song tool Udio settle lawsuit and partner on new platform, sparking backlash


Taylor Swift arrives at the 67th annual Grammy Awards on Feb. 2, 2025, in Los Angeles. Credit: Jordan Strauss/Invision/AP, File

Universal Music Group and AI song generation platform Udio have settled a copyright infringement lawsuit and agreed to team up on new music creation and streaming platform, the two companies said in a joint announcement.

Universal and Udio said Wednesday that they reached a “compensatory legal settlement” as well as new licensing agreements for recorded music and publishing that will “provide further revenue opportunities” for the record label’s artists and songwriters.

As part of the deal, Udio immediately stopped allowing people to download songs they’ve created, which sparked a backlash and apparent exodus among paying users.

The deal is the first since Universal, along with Sony Music Entertainment and Warner Records, sued Udio and another AI song generator, Suno, last year over copyright infringement.

“These new agreements with Udio demonstrate our commitment to do what’s right by our artists and songwriters, whether that means embracing new technologies, developing new business models, diversifying revenue streams or beyond,” Universal CEO Lucian Grainge said.

Financial terms of the settlement weren’t disclosed.

Universal announced another AI deal on Thursday, saying it was teaming up with Stability AI to develop “next-generation professional music creation tools.”

Universal Music and AI song tool Udio settle lawsuit and partner on new platform, sparking backlash
Kendrick Lamar performs during halftime of the NFL Super Bowl 59 football game between the Kansas City Chiefs and the Philadelphia Eagles in New Orleans, Feb. 9, 2025. Credit: AP Photo/Matt Slocum, File

Udio and Suno pioneered AI song generation technology, which can spit out new songs based on prompts typed into a chatbot-style text box. Users, who don’t need musical talent, can merely request a tune in the style of, for example, classic rock, 1980s synth-pop or West Coast rap.

Udio and Universal, which counts Taylor Swift, Olivia Rodrigo, Drake, and Kendrick Lamar among its artists, said the new AI subscription service will debut next year.

Udio CEO Andrew Sanchez said in a blog post that people will be able to use it to remix their favorite songs or mashup different tunes or song styles. Artists will be able to give permission for how their music can be used, he said.

However, “downloads from the platform will be unavailable,” he said.

AI songs made on Udio will be “controlled within a walled garden” as part of the transition to the new service, the two companies said in their joint announcement.

The move angered Udio’s users, according to posts on Reddit’s Udio forum, where they vented about feeling betrayed by the platform’s surprise move and complained that it limited what they could do with their music.

Universal Music and AI song tool Udio settle lawsuit and partner on new platform, sparking backlash
Olivia Rodrigo performs during the Glastonbury Festival in Worthy Farm, Somerset, England, on June 29, 2025. Credit: Scott A Garfitt/Invision/AP, File

One user accused Universal of taking away “our democratic download freedoms.” Another said “Udio can never be trusted again.”

Many vowed to cancel their subscriptions for Udio, which has a free level as well as premium plans that come with more features.

The deal shows how the rise of AI song generation tools like Udio has disrupted the $20 billion music streaming industry. Record labels accuse the platforms of exploiting the recorded works of artists without compensating them.

The tools have fueled debate over AI’s role in music while raising fears about “AI slop”—automatically generated, low quality mass produced content—highlighted by the rise of fictitious bands passing for real artists.

In its lawsuit filed against Udio last year, Universal alleged that specific AI-generated songs made on Udio closely resembled Universal-owned classics like Frank Sinatra’s “My Way,” The Temptations’ “My Girl” and holiday favorites like “Rockin’ Around the Christmas Tree” and “Jingle Bell Rock.”

In the “My Girl” example, a written prompt on Udio that asked for “my tempting 1964 girl smokey sing hitsville soul pop” generated a song with a “very similar melody, the same chords, and very similar backing vocals” as the hit song co-written by Smokey Robinson and recorded by The Temptations in 1964, according to the lawsuit. A link to the AI-generated song on Udio now says “Track not found.”

© 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.

Citation:
Universal Music and AI song tool Udio settle lawsuit and partner on new platform, sparking backlash (2025, October 30)
retrieved 30 October 2025
from https://techxplore.com/news/2025-10-universal-music-ai-song-tool.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





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Our Favorite Cordless Stick Vacuum Is Marked Down $50

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Our Favorite Cordless Stick Vacuum Is Marked Down


Tired of pet hair and dust in the hard-to-reach spots of your home? Our favorite pick for cordless stick vacuums, the Bissell PowerClean FurFinder, is marked down to just $180 at Amazon. That matches the best price yet for this lightweight and capable stick vacuum, the same discount as Prime Day earlier this year. It even stands up on its own when not in use, truly blurring the line between stick and upright vacuums.

  • Photograph: Nena Farrell

  • Photograph: Nena Farrell

  • Courtesy of Bissell

Bissell

PowerClean FurFinder

Just because it’s a small cordless vacuum, doesn’t mean it lacks power. The 200W motor inside does an excellent job of catching dirt, dust, and of course pet hair. If the last one in particular is a problem for you, you’re in luck, as the namesake FurFinder tool is designed specifically to pull pet hair from upholstery and fabric. Our reviewer Nena Farrell used it to remove hair from her cat tree, a notoriously tough task, and said it “left the upholstery looking new.” The HEPA filter should also help keep the spread of any pet bits in the air to a minimum.

As a stick vacuum, the FurFinder will often be tasked with getting into tight spaces and under cabinets and furniture. Thankfully, it’s equipped with a generously sized headlight that will let you spot dust bunnies even in the darkest corners of your living room. It’s still up to bigger tasks though, with a claimed 40 minutes of run-time on low, and a total of three power levels for those tougher jobs. This bundle includes a charging dock, too, so you don’t have to hunt around for a special cable, or remember to charge individual batteries, plus a crevice tool for getting in between your couch cushions, and a brush tool for bigger messes.

If you’re curious about the rest of our favorite vacuums, or you don’t have a furry loved one in your life, make sure to swing by our buying guide. This is a great option for pet owners, in particular if you’re like me and let your dog onto any piece of furniture in the house, and for the price, it could act as a second vacuum just for that purpose.



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