Tech
A New Startup Wants to Edit Human Embryos
In 2018, Chinese scientist He Jiankui shocked the world when he revealed that he had created the first gene-edited babies. Using Crispr, he tweaked the genes of three human embryos in an attempt to make them immune to HIV and used the embryos to start pregnancies.
The backlash against He was immediate. Scientists said the technology was too new to be used for human reproduction and that the DNA change amounted to genetic enhancement. The Chinese government charged him with “illegal medical practices” and he served a three-year prison sentence.
Now, a New York-based startup called Manhattan Genomics is reviving the debate around gene-edited babies. Its stated goal is to end genetic disease and alleviate human suffering by fixing harmful mutations at the embryo stage. The company has announced a group of “scientific contributors” that includes a prominent in vitro fertilization doctor, a data scientist who worked for deextinction company Colossal Biosciences, and two reproductive biologists from a major primate research center. A scientist who pioneered a technique to make embryos using DNA from three people is also involved.
“I like to take on challenges when I see them,” says cofounder Cathy Tie, a former Thiel fellow who left college at 18 to start her first company, Ranomics, a genomics screening service. As Tie sees it, that challenge is making the idea of human embryo editing more acceptable in society.
The idea of editing human embryos is tantalizing because any changes made to the reproductive cells are heritable. Snip out a disease-causing mutation in an embryo and it would be deleted from future generations as well. But gene-editing technology also has the potential to cause unintended “off-target” effects. Edit the wrong gene by mistake and it could give rise to cancer, for instance. Those mistakes would also be passed down to any future children.
While newer forms of gene editing are more precise, there are still ethical issues to contend with. The prospect of being able to manipulate the DNA of a human embryo has raised fears of a new kind of eugenics, where parents with the means to do so could make “designer babies” with traits that they select.
Tie says the goal of Manhattan Genomics—originally called the Manhattan Project when the company first launched in August—is disease correction, not enhancement. Unlike the original Manhattan Project, a secretive US government program during World War II that produced the first nuclear weapons, Tie says her venture will operate openly and transparently. “We’re revolutionizing medicine, and this technology is definitely very powerful. That’s what I think is the commonality here with manipulating the nucleus of the atom and manipulating the nucleus of the cell,” she says.
Tech
The Best Cozy Earth Pajamas Deal We’ve Seen All Year
I love having a whimsical, comfortable wardrobe, and that doesn’t apply just to daytime clothes. My pajama collection is quite extensive, with the added requirement that each pair be both cooling and extra soft. I’m someone who overheats easily in her sleep, and with sensitive skin, it’s not a winning combination.
I’ve been growing my Cozy Earth pajama collection for years, usually getting a new set during Black Friday. Obviously, that shopping event has come and gone, but this sale gives you one more chance. And, believe it or not, it’s even better than what Cozy Earth ran sale-wise for its pajamas during Cyber Week.
Tech
We Just Found Out Taylor Swift Sleeps on a Coop Pillow—They’re Having a Flash Sale to Celebrate
While I’m a mattress and sleep product expert, thanks to years of hands-on experience, I’m also aware that my opinion is not the end-all, be-all for everyone. However, when a megastar is also a fan of a product you’ve reviewed, it’s a good confirmation that you’re on the right track.
Taylor Swift, as it would turn out, is also a fan of Coop Sleep Goods—which we can confirm based on this December 10 Late Show With Stephen Colbert appearance.
Coop’s got some of our favorite pillows, particularly the Original Adjustable pillow. It comes in three shapes: the Crescent, the Cut Out, and the Classic, which is a traditional rectangular shape. I love (and regularly sleep on) the Crescent, which has a gentle curve on the bottom to allow for movement while maintaining head and neck support.
Tech
Nvidia Becomes a Major Model Maker With Nemotron 3
Nvidia has made a fortune supplying chips to companies working on artificial intelligence, but today the chipmaker took a step toward becoming a more serious model maker itself by releasing a series of cutting-edge open models, along with data and tools to help engineers use them.
The move, which comes at a moment when AI companies like OpenAI, Google, and Anthropic are developing increasingly capable chips of their own, could be a hedge against these firms veering away from Nvidia’s technology over time.
Open models are already a crucial part of the AI ecosystem with many researchers and startups using them to experiment, prototype, and build. While OpenAI and Google offer small open models, they do not update them as frequently as their rivals in China. For this reason and others, open models from Chinese companies are currently much more popular, according to data from Hugging Face, a hosting platform for open source projects.
Nvidia’s new Nemotron 3 models are among the best that can be downloaded, modified, and run on one’s own hardware, according to benchmark scores shared by the company ahead of release.
“Open innovation is the foundation of AI progress,” CEO Jensen Huang said in a statement ahead of the news. “With Nemotron, we’re transforming advanced AI into an open platform that gives developers the transparency and efficiency they need to build agentic systems at scale.”
Nvidia is taking a more fully transparent approach than many of its US rivals by releasing the data used to train Nemotron—a fact that should help engineers modify the models more easily. The company is also releasing tools to help with customization and fine-tuning. This includes a new hybrid latent mixture-of-experts model architecture, which Nvidia says is especially good for building AI agents that can take actions on computers or the web. The company is also launching libraries that allow users to train agents to do things using reinforcement learning, which involves giving models simulated rewards and punishments.
Nemotron 3 models come in three sizes: Nano, which has 30 billion parameters; Super, which has 100 billion; and Ultra, which has 500 billion. A model’s parameters loosely correspond to how capable it is as well as how unwieldy it is to run. The largest models are so cumbersome that they need to run on racks of expensive hardware.
Model Foundations
Kari Ann Briski, vice president of generative AI software for enterprise at Nvidia, said open models are important to AI builders for three reasons: Builders increasingly need to customize models for particular tasks; it often helps to hand queries off to different models; and it is easier to squeeze more intelligent responses from these models after training by having them perform a kind of simulated reasoning. “We believe open source is the foundation for AI innovation, continuing to accelerate the global economy,” Briski said.
The social media giant Meta released the first advanced open models under the name Llama in February 2023. As competition has intensified, however, Meta has signaled that its future releases might not be open source.
The move is part of a larger trend in the AI industry. Over the past year, US firms have moved away from openness, becoming more secretive about their research and more reluctant to tip off their rivals about their latest engineering tricks.
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