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A Gene Editing Therapy Cut Cholesterol Levels by Half

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A Gene Editing Therapy Cut Cholesterol Levels by Half


In a step toward the wider use of gene editing, a treatment that uses Crispr successfully slashed high cholesterol levels in a small number of people.

In a trial conducted by Swiss biotech company Crispr Therapeutics, 15 participants received a one-time infusion meant to switch off a gene in the liver called ANGPTL3. Though rare, some people are born with a mutation in this gene that protects against heart disease with no apparent adverse consequences.

The highest dose tested in the trial reduced both “bad” LDL cholesterol and triglycerides by an average of 50 percent within two weeks after treatment. The effects lasted at least 60 days, the length of the trial. The results were presented today at the American Heart Association’s annual meeting and published in The New England Journal of Medicine.

The Nobel Prize–winning Crispr technology has mostly been used to address rare diseases, but these latest findings, while early, add to the evidence that the DNA-editing tool could be used to treat common conditions as well.

“This will probably be one of the biggest moments in the arc of Crispr’s development in medicine,” Samarth Kulkarni, CEO of Crispr Therapeutics, tells WIRED. The company is behind the only approved gene-editing treatment on the market, Casgevy, which treats sickle cell disease and beta thalassemia.

The American Heart Association estimates that about a quarter of adults in the US have elevated LDL levels. A similar number have high triglycerides. LDL cholesterol is the waxy substance in the blood that can clog and harden arteries over time. Triglycerides, meanwhile, are the most common type of fat found in the body. High levels of both raise the risk of heart attack and stroke.

The Phase I trial was conducted in the UK, Australia, and New Zealand between June 2024 and August 2025. Participants were between the ages of 31 and 68 and had uncontrolled levels of LDL cholesterol and triglycerides. The trial tested five different doses of the Crispr infusion, which took about two and a half hours on average to administer.

“These are very sick people,” says Steven Nissen, senior author and chief academic officer of the Heart, Vascular and Thoracic Institute at Cleveland Clinic, which independently confirmed the trial’s results. “The tragedy of this disease is not just that people die young, but some of them will have a heart attack, and their lives are never the same again. They don’t get back to work, they develop heart failure.”

One trial participant, a 51-year-old man, died six months after receiving the lowest dose of the treatment, which was not associated with a lowering of cholesterol and triglycerides. The death was related to his existing heart disease, not the experimental Crispr treatment. The man had a rare, inherited genetic form of high cholesterol and previously had several procedures to improve blood flow to his heart.



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Microsoft to pursue superintelligence after OpenAI deal

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Microsoft to pursue superintelligence after OpenAI deal


Credit: Unsplash/CC0 Public Domain

Microsoft Corp. is pursuing a more powerful form of AI called “superintelligence” it hopes will be capable of making advances in areas like medicine and materials science.

Mustafa Suleyman, chief of the Microsoft AI group, will lead what the company is calling the MAI Superintelligence Team that will target hypothetical milestones that are even more ambitious than artificial general intelligence. That’s the often ambiguous term that outfits like OpenAI use to describe systems capable of demonstrating human-level performance. Previously, Microsoft had agreed not to pursue AGI as part of its partnership with OpenAI.

“If AGI is often seen as the point at which an AI can match at all tasks, then superintelligence is when it can go far beyond that performance,” Suleyman said in a blog post announcing the push, which he says will work toward personal AI companions and breakthroughs in and clean energy.

The team will aim to build what he calls Humanist Superintelligence, seeking to avoid potential risks associated with development of powerful automated tools and work for the benefit of people instead of technological milestones.

OpenAI, Meta Platforms Inc. and other companies are also increasingly focusing on superintelligence as the new goalpost for AI development. The term “superintelligence,” like AGI, is imprecise: It’s unclear how capable, exactly, AI needs to be at certain tasks before it crosses the threshold from “general” to “super” intelligence.

The announcement comes in the wake of a renegotiated agreement between Microsoft and OpenAI that determined the software maker’s stake in the startup and altered portions of their relationship. That included removing a prior prohibition on Microsoft’s development of advanced AI tools, which had limited much of the Redmond, Washington-based company’s work to smaller, less broadly capable models than those that power ChatGPT.

Thursday’s announcement formalizes a project that Microsoft had been laying the groundwork for since last March, when the company hired Suleyman and licensed the intellectual property of his startup, Inflection AI.

With a combination of reorganized Microsoft teams and new hires, Suleyman set about building a new family of Microsoft AI models, which to date remain much smaller in scale than the most capable products from OpenAI or Alphabet Inc.”s Google.

Suleyman told employees in September that Microsoft would make “significant investments” to expand the capability of those models.

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Paramount+ Coupon Codes and Deals: Free Trial, Student Deals, and Military Discounts for November 2025

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Paramount+ Coupon Codes and Deals: Free Trial, Student Deals, and Military Discounts for November 2025


The most talked-about TV show in the country right now, South Park, is on Paramount+. Don’t you want to know what got Trump in such a tizzy?

Stream the much buzzed-about South Park, fan-favorite Yellowstone, original series MobLand, and rebooted crime drama Dexter & Dexter on Paramount+. The streaming network has a bingeable TV series for almost everyone. And whether you want to remember Lindsay Lohan’s old face in the classic Mean Girls flick, or wonder just how many more sequels Tom Cruise has left in him with Top Gun: Maverick, there’s a bevy of films to stream, too.

If you’re like me and have at least half a dozen streaming services, our Paramount+ coupon codes can help you save so you can watch the content you want without having to get rid of one of your other beloved content platforms. (I love pretending the world isn’t full of suffering around me and instead focus on Sylvester Stallone’s ever-changing Play-Doh face in Tulsa King.)

Try Paramount+ Free With a One-Week Trial

If you’re unsure if you’ll actually want to commit to Paramount+, or if there’s a sports event like the Super Bowl or March Madness games and you only need to access the content for a little while, Paramount+’s free trial is a great option. The trial lasts one week, is for new subscribers only, and can’t be paired with other offers.

There are tiered plans, including Essential, which allows for 3 devices, select Showtime series, NFL games, and can be streamed on up to 3 devices at once, but has ads; and Premium, which includes all that except there are no ads, downloadable content, CBS live, and all of Showtime content.

Save on a Paramount+ Subscription With Student and Military Discounts

If you’re a student now (or have your student ID lying around somewhere), you can get a Paramount+ plan at only $4 a month. All you have to do is verify your student status and you’ll get 50% off any plan of your choosing for the first year. Or if you’re a military member, Paramount+ gives 50% off any subscription for life.

Stream Live Sports and Events on Paramount+

For better or worse, I’m a Chiefs fan (cue the booing). I usually get a Paramount+ plan during the football season to keep up with my favorite beefy, TBI-ridden men. You can stream all of the NFL coverage you want all season long, plus, 24/7 live channels are now streaming on Paramount+, so you’ll never need to give your brain the time to process the horrors.

Watch Paramount+ Originals and Fan Favorites

TThere’s truly something for everyone in the family, with movies, kids’ shows, and Paramount+ originals included in every plan. If you’re feeling spooky, I’d recommend Dexter: Resurrection, or Yellowjackets, but if you’re looking for something more family-friendly, there’s super popular cartoons like Rango or Sonic the Hedgehog to choose from.

Looking for specific recommendations? I’ve got you. There are tons of great new releases coming to Paramount+ this November, including Landman season 2, new Paramount+ original comedy series Crutch starring Tracy Morgan, and new episodes of (my favorite) newly premiered Ink Master Season 17. There are also tons of new movies, including The Cut, a boxing drama starring Orlando Bloom, dark comedy Shell, and true-crime tale My Nightmare Stalker: The Eva LaRue Story. Plus, Paramount+ will be playing the important NFL holiday games, like the Chiefs-Cowboys Thanksgiving Day game.

Check out the wide breadth of TV and movie content to choose from on Paramount+ (and use the Paramount+ promo codes above to save on whatever plan you decide).



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The Government Shutdown Is a Ticking Cybersecurity Time Bomb

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The Government Shutdown Is a Ticking Cybersecurity Time Bomb


Amid a government shutdown that has dragged on for more than five weeks, the United States Congressional Budget Office said on Thursday that it recently suffered a hack and moved to contain the breach. CBO provides nonpartisan financial and economic data to lawmakers, and The Washington Post reported that the agency was infiltrated by a “suspected foreign actor.”

CBO spokesperson Caitlin Emma told WIRED in a statement that it has “implemented additional monitoring and new security controls to further protect the agency’s systems” and that “CBO occasionally faces threats to its network and continually monitors to address those threats.” Emma did not address questions from WIRED about whether the government shutdown has impacted technical personnel or cybersecurity-related work at CBO.

With increasing instability in the Supplemental Nutrition Assistance Program (SNAP) leaving Americans hungry, air traffic control personnel shortages disrupting flights, financial devastation for federal workers, and mounting operational shortages at the Social Security Administration, the shutdown is increasingly impacting every corner of the US. But researchers, former and current government workers, and federal technology experts warn that gaps in foundational activities during the shutdown—things like system patching, activity monitoring, and device management—could have real effects on federal defenses, both now and for years to come.

“A lot of federal digital systems are still just running in the cloud throughout the shutdown, even if the office is empty,” says Safi Mojidi, a longtime cybersecurity researcher who previously worked for NASA and as a federal security contractor. “If everything was set up properly, then the cloud offers an important baseline of security, but it’s hard to rest easy during a shutdown knowing that even in the best of times there are problems getting security right.”

Even before the shutdown, federal cybersecurity workers were being impacted by reductions in force at agencies like the Department of Homeland Security’s Cybersecurity and Infrastructure Security Agency—potentially hindering digital defense guidance and coordination across the government. And CISA has continued cutting staff during the shutdown as well.

In a statement, spokesperson Marci McCarthy said “CISA continues to execute on its mission” but did not answer WIRED’s specific questions about how its work and digital defenses at other agencies have been impacted by the government shutdown, which she blamed on Democrats.

The government’s transition to the cloud over the last decade, as well as increased attention to cybersecurity in recent years, does provide an important backstop for a disruption like a shutdown. Experts emphasize, though, that the federal landscape is not homogenous, and some agencies have made more progress and are better equipped than others. Additionally, missed and overlooked digital security work that accumulates during the shutdown will create a backlog when workers return that could be difficult to surmount.



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