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Christian McCaffrey shines vs former Panthers, leads 49ers to Monday night victory
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Christian McCaffrey faced his former Carolina Panthers team for the first time since his trade to the San Francisco 49ers in 2022.
The All-Pro running back powered San Francisco to a 20-9 victory on “Monday Night Football,” finding the end zone and leading both teams in total yards from scrimmage.
The 49ers (8-4) are now firmly in the NFC playoff picture, while the Panthers (6-6) missed a chance to take sole possession of the NFC South lead.
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Christian McCaffrey of the San Francisco 49ers is tackled by Claudin Cherelus of the Carolina Panthers at Levi’s Stadium on Nov. 24, 2025, in Santa Clara, California. (Jed Jacobsohn/Getty Images)
While McCaffrey shined on the primetime stage, it was a rough night for both quarterbacks.
Brock Purdy, who threw three touchdowns in his return the previous week, struggled with turnovers, tossing three interceptions on consecutive possessions in the first half.
San Francisco opened strong with a 15-play, 75-yard touchdown drive, capped by Purdy’s short pass to Jauan Jennings, who fought through three Panthers defenders to score. But after a quick Panthers three-and-out, Purdy’s first pass on the next series was picked off by Jaycee Horn, giving Carolina the ball at the San Francisco 16-yard line.
But this night wasn’t just about Purdy’s turnovers — Bryce Young had some issues as well.
On first-and-goal from the 1, Young appeared to have room to run toward the pylon, but he instead tried a pass to tight end Mitchell Evans. Ji’Ayir Brown was right there to snag the interception in the end zone and bail out Purdy for his earlier mistake.
Unfortunately for San Francisco, Purdy was picked off by Mike Jackson in the opposite end zone when he tried to find Ricky Pearsall for a touchdown. The route was read perfectly by the veteran cornerback. Upon replay, tight end George Kittle appeared wide open and might have scored with a short pass, but Purdy was looking for the big play on the throw.
Then Purdy was really kicking himself after Horn secured his second interception of the game — a savvy play as he roamed free in the middle of the field and Purdy simply didn’t see him on a pass intended for Pearsall. The Panthers finally got points on the board after a field goal cut the deficit to 7-3.
Jauan Jennings of the San Francisco 49ers celebrates after scoring a touchdown against the Carolina Panthers at Levi’s Stadium on Nov. 24, 2025, in Santa Clara, California. (Jed Jacobsohn/Getty Images)
It was only 10-3 at halftime, but the 49ers finally got McCaffrey into the end zone in the third quarter against his former team. His 12-yard touchdown run capped a 13-play, 80-yard drive by San Francisco, where the star back got key blocks from Kittle and fullback Kyle Juszczyk to reach the end zone.
McCaffrey finished the game with 89 rushing yards and seven catches for 53 yards.
The Panthers weren’t completely out of the game despite the 17-3 deficit, thanks to rookie receiver Tetairoa McMillan hauling in a 29-yard strike from Young with 49 seconds left in the third quarter to make it a 17-9 game after a failed two-point conversion.
The 49ers created some separation after adding another field goal, but the Panthers still had plenty of time in the fourth quarter to make things interesting. Unfortunately for them, Brown jumped a route across the middle intended for McMillan, and Young threw it right to him.
The interception virtually iced the game, as Ryan Fitzgerald missed a 57-yard field goal with 2:47 left in the fourth quarter during the Panthers’ desperate attempt to get points.
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Looking at the box score, Kittle led the game with 78 yards on six catches, while Jennings finished with 41 yards on five grabs.
For the Panthers, Rico Dowdle, Chuba Hubbard and Young combined for just 69 rushing yards, though Dowdle had four catches for 36 yards. Hubbard added four catches for 27 yards.
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The Carolina Panthers created havoc for the Los Angeles Rams and received a boost from the sloppy weather as they defeated the best team in the NFC, 31-28.
Carolina notched its seventh win of the year. It’s the first time they have won at least seven games since the 2022 season when Matt Rhule, and eventually Steve Wilks, were at the helm. The Panthers also snapped the Rams’ six-game winning streak.
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Carolina Panthers quarterback Bryce Young runs against the Los Angeles Rams during the first half of an NFL football game, Sunday, Nov. 30, 2025, in Charlotte, North Carolina (Rusty Jones/AP Photo)
Rams quarterback Matthew Stafford entered the game as the NFL MVP favorite. It seemed like he was going to have a big game as he led the team down for a touchdown on the opening drive. At the time, it was his 28th touchdown pass without an interception, which broke an NFL record.
The good vibes didn’t last long as Stafford threw an interception on his next drive and later had a pick six to Panthers cornerback Mike Jackson. The Panthers’ defense then forced Stafford to fumble the ball on the Rams’ final drive, which sunk any hopes of them coming back to force overtime or win the game.
Panthers quarterback Bryce Young was 15-of-20 with 206 passing yards and three touchdown passes. He found rookie wide receiver Tetairoa McMillan for a 43-yard go-ahead touchdown with 6:34 left in the game. It was McMillan’s only catch of the game.
Carolina Panthers safety Nick Scott celebrates after intercepting a pass against the Los Angeles Rams during the first half of an NFL football game, Sunday, Nov. 30, 2025, in Charlotte, North Carolina. (Jacob Kupferman/AP Photo)
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Carolina’s Jalen Coker had four catches for 74 yards and a touchdown. Running back Chuba Hubbard had two catches for 41 yards and a touchdown. He also added 83 yards on the ground on 17 carries.
Stafford finished 18-of-28 with 243 passing yards and two touchdown passes. Both touchdowns were to Davante Adams, who finished with four catches for 58 yards.
The Panthers’ (7-6) win kept them in contention for the NFC South lead. The Tampa Bay Buccaneers have a higher winning percentage after their win over the Arizona Cardinals, moving to 7-5.
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The Rams’ grip on the conference was loosened. The loss meant the Chicago Bears have the best record in the NFC. Chicago defeated the Philadelphia Eagles on Black Friday.
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Kiffin became a hovering theme of the latter part of the college football season as his future at Mississippi became uncertain.
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That’s a wrap on the regular season. All 31 automatic bids have been decided. Next up is the Selection Show on Sunday at 6 p.m. ET on ESPN where the other 33 at-large teams along with the seeding will be revealed.
Volleyball seeds the top-eight teams in each region and the top four serve as first- and second-round hosts. The rest of the bracket is filled out to balance it competitively and geographically. The highest remaining seeds also host the regionals, and the 2025 Final Four is in Kansas City, Missouri, on Dec. 18 with the finals on Dec. 21.
Bracket watch
Pittsburgh’s win over Louisville, although much closer than the sweep would indicate, was still convincing enough to push the Panthers onto the top line as the final No. 1 seed. The other three top seeds — Nebraska, Kentucky and Texas — should be easy for the committee. The big discussion and decision-making will likely center around which teams slot as No. 2 seeds and which ones falls on the No. 3 line. That group includes teams such as Arizona State, Stanford, Louisville, Creighton, SMU, Wisconsin and Texas A&M with résumés that are so close; differentiating them won’t be easy.
The final spots for the right to host the first and second rounds will also take some time. Miami and USC seem to have played their way into the top 16 with good finishes to the regular season. Indiana slipped a bit down the stretch. The Hoosiers might just hold onto a spot in the top 16.
Top seedings
No. 1 seeds: Nebraska, Kentucky, Texas, Pittsburgh
No. 2 seeds: Arizona State, Texas A&M, Creighton, SMU
No. 3 seeds: Stanford, Wisconsin, Louisville, Purdue
No. 4 seeds: Miami, Minnesota, USC, Indiana
No. 5 seeds: Kansas, BYU, Baylor, Tennessee
No. 6 seeds: TCU, Kansas State, Colorado, Iowa State
No. 7 seeds: Penn State, UTEP, Western Kentucky, Northern Iowa
No. 8 seeds: Marquette, North Carolina, Florida, San Diego
Rest of the field (alphabetical): American, Arizona, Arkansas State, Campbell, UCLA, Cal Poly, Central Arkansas, Coppin State, Eastern Illinois, Fairfield, Florida A&M, Georgia Tech, High Point, Long Island, Loyola-Chicago, Maryland-Baltimore County, Northern Colorado, Princeton, Rice, St. Thomas, South Dakota State, South Florida, Stephen F. Austin, Toledo, Tulsa, Utah State, Utah Valley, Villanova, Western Kentucky, Wofford, Wright State, Xavier
(The rest of the field teams wouldn’t be seeded)
Bubble watch
The biggest change on the bubble in the season’s final weekend was Arizona playing itself into the field with two wins. The Wildcats beat Cincinnati in four sets Saturday in a match that became a de facto play-in game. The Bearcats’ two losses over the past three days were backbreaking. Oregon picked up a pair of wins, but beating Rutgers and Maryland weren’t enough to elevate the Ducks, who lack a significant nonconference victory and didn’t play the nonconference schedule of South Florida.
Last Four In: Georgia Tech, Villanova, Arizona, South Florida
First Four Out: Oregon, Cincinnati, Dayton, Missouri
Next Four Out: Auburn, Florida State, Pepperdine, James Madison
Conference breakdown
Big 12: 8
Big Ten: 8
ACC: 7
SEC: 5
Big East: 4
American: 3
CUSA: 2
Summit: 2
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