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Crispr Offers New Hope for Treating Diabetes

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Crispr Offers New Hope for Treating Diabetes


Crispr gene-editing technology has demonstrated its revolutionary potential in recent years: It has been used to treat rare diseases, to adapt crops to withstand the extremes of climate change, or even to change the color of a spider’s web. But the greatest hope is that this technology will help find a cure for a global disease, such as diabetes. A new study points in that direction.

For the first time, researchers succeeded in implanting Crispr-edited pancreatic cells in a man with type 1 diabetes, an autoimmune disease where the immune system attacks insulin-producing cells in the pancreas. Without insulin, the body is then unable to regulate blood sugar. If steps aren’t taken to manage glucose levels by other means (typically, by injecting insulin), this can lead to damage to the nerves and organs—particularly the heart, kidneys, and eyes. Roughly 9.5 million people worldwide have type 1 diabetes.

In this experiment, edited cells produced insulin for months after being implanted, without the need for the recipient to take any immunosuppressive drugs to stop their body attacking the cells. The Crispr technology allowed the researchers to endow the genetically modified cells with camouflage to evade detection.

The study, published last month in The New England Journal of Medicine, details the step-by-step procedure. First, pancreatic islet cells were taken from a deceased donor without diabetes, and then altered with the gene-editing technique Crispr-Cas12b to allow them to evade the immune response of the diabetes patient. Cells altered like this are said to be “hypoimmune,” explains Sonja Schrepfer, a professor at Cedars-Sinai Medical Center in California and the scientific cofounder of Sana Biotechnology, the company that developed this treatment.

The edited cells were then implanted into the forearm muscle of the patient, and after 12 weeks, no signs of rejection were detected. (A subsequent report from Sana Biotechnology notes that the implanted cells were still evading the patient’s immune system after six months.)

Tests run as part of the study recorded that the cells were functional: The implanted cells secreted insulin in response to glucose levels, representing a key step toward controlling diabetes without the need for insulin injections. Four adverse events were recorded during follow-ups with the patient, but none of them were serious or directly linked to the modified cells.

The researchers’ ultimate goal is to apply immune-camouflaging gene edits to stem cells—which have the ability to reproduce and differentiate themselves into other cell types inside the body—and then to direct their development into insulin-secreting islet cells. “The advantage of engineering hypoimmune stem cells is that when these stem cells proliferate and create new cells, the new cells are also hypoimmune,” Schrepfer explained in a Cedars-Sinai Q+A earlier this year.

Traditionally, transplanting foreign cells into a patient has required suppressing the patient’s immune system to avoid them being rejected. This carries significant risks: infections, toxicity, and long-term complications. “Seeing patients die from rejection or severe complications from immunosuppression was frustrating to me, and I decided to focus my career on developing strategies to overcome immune rejection without immunosuppressive drugs,” Schrepfer told Cedars-Sinai.

Although the research marks a milestone in the search for treatments of type 1 diabetes, it’s important to note that the study involved one one participant, who received a low dose of cells for a short period—not enough for the patient to no longer need to control their blood sugar with injected insulin. An editorial by the journal Nature also says that some independent research groups have failed in their efforts to confirm that Sana’s method provides edited cells with the ability to evade the immune system.

Sana will be looking to conduct more clinical trials starting next year. Without overlooking the criticisms and limitations of the current study, the possibility of transplanting cells modified to be invisible to the immune system opens up a very promising horizon in regenerative medicine.

This story originally appeared on WIRED en Español and has been translated from Spanish.



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Top Home Depot Promo Codes for October 2025

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Top Home Depot Promo Codes for October 2025


The company pretty much invented the hardware superstore when it began in 1978, just by being so big. They inflated the neighborhood tool shop into a whole city of lumber, hammers, caulk, power saws, and big rolls of wire. I would know I’m in a Home Depot blindfolded, because of a distinct quality to the air—crisp and particulate, smelling like wood dust and paint and the oiled metal of power tools. The Home Depot smell is buried deep in my childhood, filed somewhere between “building a deck” and “first day of spring.” Anyway, the Home Depot website is just as big. And while it doesn’t smell like sawdust, it’s easier to find stuff. And as it turns out, the hardware giant also goes hard on discounts, slashing grills and garden and outdoor power tools by up to 50%, not to mention smokers like the new Traieger Woodridge (8/10, WIRED Recommends) also sold at Home Depot. Our roundup includes Home Depot promo codes, new customer coupons, free shipping offers, and Pro rewards to drop prices by as much as 60% when you buy online.

Check out WIRED’s recommendations in our guide to the Best Grills to Up Your Cookout Game. Power tools and hand tools are also discounted, as are garden flowers. Nervous about planting? WIRED has some advice for first time gardeners.

Get 10% Off With Home Depot Promo Codes and Coupons

Autumn is in the air, which means falling leaves and everyone’s favorite spooky holiday. Home Depot is the perfect place for a myriad of needs as the seasons change, including leaf blowers and Home Depot’s iconic Halloween decor collection that just launched now up to 50% off, including outdoor and yard decor (which includes free delivery). WIRED writer Nena Farrell reviewed Home Depot’s iconic giant Halloween skeleton a few months ago.

If you register for Home Depot’s Style and Decor newsletter, you get a special code for 10 percent off on furniture and home accents. Or if you sign up for the Home Depot coupon newsletter, you get an immediate $5 off the next in-store purchase of $50 or more. Another easy way to get 5% off at Home Depot is to set up a subscription for your go to products and automatically get 5% off and free delivery on your order.

Use Top Home Depot Coupons for up to $500 Off Tools, Appliances, and More

Home Depot’s website makes it super easy to shop the best current discounts by department in the savings portal, making it easier than ever to find the best deals for any home reno need. Right now, savings include up to $400 off (including up to 50% off) on top tool brands including Milwaukee, Ryobi, and DeWalt, plus, you’ll get a free battery or tool kit with tool purchase.

Home Depot also offers huge savings on bundle deals, including up to $400 off LG and $500 off Samsung kitchen appliances when you buy 2 or more, and huge savings on home decor, like 40% off living room furniture including sectionals and modular sofas. You can also shop top sellers like sectional sofas for under $500. Plus, the Home Depot Fall Savings event is always a great way to save more on tools and other home essentials.

Get 40% Off With Home Depot Deal of the Day Coupons

Home Depot coupons of the moment include whopper deals like 15% off storage solutions, 35% off washers and dryers, and $2,000 off LG kitchen appliances when you buy 2 or more. Explore more deals on kitchen and other furniture too, by checking out the deals of the moment here. Like we’ve stated, there are so many ways to save at Home Depot, even when you’re shopping online. Special Buy of the Days include steep price drops on certain products or entire brands—but the significant price drops only last for 24 hours. Recently they’ve highlighted essentials for the Fall Bath Event, in which daily deals include 40% off faucets, 25% off toilets and bathtubs, and 40% off vanities. That’s a whole lot of savings for one of the most expensive home renovations you can do.

Deals include smart home items WIRED has covered extensively, like Nest learning thermostats (9/10, WIRED Recommends). Need advice on setting up a smart home? WIRED has your back. Not only do Deals of the Days (and over 1 million products) qualify for free shipping, but you can also get free delivery to your local Home Depot store or straight to your door with online orders over $45.

Save 20% With Home Depot Pro Xtra Discounts

Home Depot also offers a loyalty program called Pro Xtra for frequent flyers, whether you’re a contractor or just undergoing a serious remodel this year. This means exclusive prices up to 20% off, 10% discounts on bulk buys, a rewards point system, and occasional $50 off $250 coupons too. Painting the house? The program also nets you 10 to 20 percent off paint and primers. Pro Xtra offers multiple tiers, from basic membership to Elite and VIP.

Special Buys of the Week are bargains that are worth checking out, and pros can get discounts with the Pro Special Buy of the Week—and that’s on top of exclusive discounts and everyday discounted pricing on items. Hot offers this week include: free tools or batteries with your purchase of tools from Milwaukee, RYOBI, and more premium brands, plus 20% off flooring. Also grab 40% off bathroom products like Kohler showers, tubs, vanities, faucets, tubs, and toilets, including luxury upgrades like Horow smart toilets and bidets.

Get 10% Off With the Home Depot Military Discount

Home Depot has long maintained a program offering discounts to active service members, veterans, and their spouses, offering 10 percent off all eligible purchases. You’ll need to register to verify your military status through SheerID, and from then on you can just scan your virtual ID or enter your phone number at checkout, same way you do at the grocery store. Note that military discounts are limited to $400 each calendar year, and this resets each year. Some commodity products are excluded, including lumber, wire, and building materials. Appliances are also out in the cold, but military families may still find special deals or tax-free shopping through Home Depot’s Military Exchange Program.



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The hidden military pressures behind the new push for small nuclear reactors

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The hidden military pressures behind the new push for small nuclear reactors


Credit: Pixabay/CC0 Public Domain

Donald Trump’s recent visit to the UK saw a so-called “landmark partnership” on nuclear energy. London and Washington announced plans to build 20 small modular reactors and also develop microreactor technology—despite the fact no such plants have yet been built commercially anywhere in the world.

The UK , Keir Starmer, promised these plans will deliver a “golden age” of that will also “drive down bills.” Yet the history of has been decades of overhype, soaring costs and constant delays. Around the world, the trends point the wrong way.

So why the renewed excitement about going nuclear? The real reasons have less to do with energy security, or climate change—and far more to do with military power.

At first sight, the case may seem obvious. Nuclear supporters frame small modular reactors, or SMRs, as vital for cutting emissions, meeting rising demand for electricity from cars and data centers. With large nuclear plants now prohibitively expensive, smaller reactors are billed as an exciting new alternative.

But these days even the most optimistic industry analyses concede that nuclear—even SMRs—is unlikely to compete with renewables. One analysis in New Civil Engineer published earlier this year concluded that SMRs are “the most expensive source per kilowatt of electricity generated when compared with natural gas, traditional nuclear and renewables.”

Independent assessments—for instance by the formerly pro-nuclear Royal Society—find that 100% renewable systems outperform any energy system, including nuclear on cost, flexibility and security. This helps explain why worldwide statistical analysis shows nuclear power is not generally linked to carbon emissions reductions, while renewables are.

Partly, the enthusiasm for SMRs can be explained by the loudest institutional voices tending to have formal pro-nuclear remits or interests: they include the industry itself and its suppliers, nuclear agencies, and governments with entrenched military nuclear programs. For these interests, the only question is which kinds of nuclear reactors to develop, and how fast. They don’t wonder if we should build reactors in the first place: the need is seen as self-evident.

At least big nuclear reactors have benefited from economies of scale and decades of technological optimization. Many SMR designs are just “powerpoint reactors,” existing only in slides and feasibility studies. Claims these unbuilt designs “will cost less” are speculative at best.

Investment markets know this. While financiers see SMR hype as a way to profit from billions in government subsidies, their own analyses are less enthusiastic about the technology itself.

So why then, all this attention to nuclear in general and smaller reactors in particular? There is clearly more to this than meets the eye.

The hidden link

The neglected factor is the military dependence on civil nuclear industries. Maintaining a nuclear-armed navy or weapons program requires constant access to generic technologies, skilled workers and special materials. Without a civilian nuclear industry, military nuclear capabilities are significantly more challenging and costly to sustain.

Nuclear submarines are especially important here as they would very likely require national reactor industries and their supply chains even if there was no civil nuclear power. Barely affordable even vessel by vessel, nuclear submarines become even more expensive when the costs of this “submarine industrial base” is factored in.

Rolls-Royce is an important link here, as it already builds the UK’s submarine reactors and is set to build the newly announced civil SMRs. The company said openly in 2017 that a civil SMR program would “relieve the Ministry of Defense of the burden of developing and retaining skills and capability.”

Here, as emphasized by Nuclear Intelligence Weekly in 2020, the Rolls-Royce SMR program has an important “symbiosis with UK military needs.” It is this dependency that allows military costs (in the words of a former executive with submarine builders BAE Systems), to be “masked” behind civilian programs.

By funding civil nuclear projects, taxpayers and consumers cover military uses of nuclear power in subsidies and higher bills—without the added spending appearing in defense budgets.

When the UK government funded us to investigate the value of this transfer, we put it at around £5 billion per year in the UK alone. These costs are masked from , covered by revenues from higher electricity prices and the budgets of supposedly civilian government agencies.

This is not a conspiracy but a kind of political gravitational field. Once governments see nuclear weapons as a marker of global status, the funding and political support becomes self-perpetuating.

The result is a strange sort of circularity: nuclear power is justified by and cost arguments that don’t stand up, but is in reality sustained for strategic reasons that remain unacknowledged.

A global pattern

The UK is not unique, though other nuclear powers are much more candid. US energy secretary Chris Wright described the US-UK nuclear deal as important for “securing nuclear supply chains across the Atlantic.” Around US$25 billion a year (£18.7 billion) flows from civil to military nuclear activity in the US.

Russia and China are both quite open about their own inseparable civil-military links. French president Emmanuel Macron put it clearly: “Without civilian nuclear, no military nuclear, without military nuclear, no civilian nuclear.”

Across these states, military nuclear capabilities are seen as a way to stay at the world’s “top table”. An end to their civilian program would threaten not just jobs and energy, but their great power status.

The next frontier

Beyond submarines, the development of “microreactors” is opening up new military uses for nuclear power. Microreactors are even smaller and more experimental than SMRs. Though they can make profits by milking military procurement budgets, they make no sense from a commercial energy standpoint.

However, microreactors are seen as essential in US plans for battlefield power, space infrastructure and new “high energy” anti-drone and missile weaponry. Prepare to see them become ever more prominent in “civil” debates—precisely because they serve military goals.

Whatever view is taken of these military developments, it makes no sense to pretend they are unrelated to the civil nuclear sector. The real drivers of the recent US–UK nuclear agreement lie in military projection of force, not civilian power production. Yet this remains absent from most discussions of energy policy.

It is a crucial matter of democracy that there be honesty about what is really going on.

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This Gas Pizza Oven Was My Favorite of the Summer. It’s Half Off Today

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This Gas Pizza Oven Was My Favorite of the Summer. It’s Half Off Today


Cookware brand All-Clad surprised me this year. This summer, it breezed into the backyard pizza world with a debut pizza oven that I like as well as any oven I’ve tested this year. Right now, that excellent All-Clad gas-powered pizza oven is a whopping $800 off the suggested retail price, only at the All-Clad site.

What’s so good about the oven? The All-Clad gas-powered pizza oven heats up fast, and crests 900 degrees Fahrenheit after 20 minutes. It’s insulated well, comes with a built-in thermometer that’s pretty accurate, and it’s made with the sturdy stainless steel All-Clad is known for.

  • Photograph: Matthew Korfhage

  • Photograph: Matthew Korfhage

  • Photograph: Matthew Korfhage

But especially, All-Clad’s pizza oven comes with a rotating pizza stone that removes a lot of the fuss and bother of cooking pizza evenly. Instead of having to hover nervously over each pie with a pizza peel, in order to turn the pizza before the backside burns, all I have to do is launch the pizza in the middle of the pizza stone.

The oven does the rest, spinning the pizza at a rate of one revolution every 40 seconds or so. It’s not foolproof—you have to launch the pizza in the center of the pizza stone to get an even cook—but it is a game-changer. This is true especially if I’m making multiple pizzas in a go-round. It means I’m able to prep the next pie while the current one is still spinning and baking.

The AllClad Pizza Oven Is 800 Off Right Now

Photograph: Matthew Korfhage



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