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Pfizer boosts obesity drug prospects with $7.3 billion deal to buy Metsera

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Pfizer boosts obesity drug prospects with .3 billion deal to buy Metsera


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Pfizer on Monday said it would buy weight loss drugmaker Metsera in an up to $7.3 billion deal, including future payments, as it scrambles to win a slice in the booming obesity drug market. 

Pfizer said it will pay an initial $47.50 a share in cash for Metsera, a nearly 43% premium to the biotech company’s Friday’s closing price of $33.32. That gives the deal an enterprise value of $4.9 billion. 

The pact also includes a contingent value right worth up to $22.50 a share based on potential clinical and regulatory achievements for Metsera’s medicines, which could bring the total value to $70 a share. 

The deal is expected to close at the end of the year. Shares of Metsera rose more than 60% in premarket trading on Monday, while Pfizer’s stock rose more than 1%. 

The move comes after a string of setbacks for Pfizer in the obseity space. The pharmaceutical giant struggled to develop its own lead obesity drug candidate, danuglipron, before deciding to scrap it entirely in April due to safety concerns. Pfizer also discontinued a different once-daily pill in June 2023 due to elevated liver enzymes in patients who received it. 

Pfizer has earlier-stage obesity drugs in its pipeline that work in different ways, but the company has faced mounting investor pressure to accelerate its push into the market.

The opportunity could be huge. Some analysts expect the weight loss drug space could be worth roughly $100 billion by the 2030s, with room for new rivals to compete with popular injections from Eli Lilly and Novo Nordisk.

Metsera, founded in 2022, brings a pipeline of both oral and injectable treatments with different targets that the company had picked up through its own licensing and acquisition deals. That includes a GLP-1 drug called MET-233i, which helped patients lose up to 8.4% of their weight in 36 days in a small, early-stage trial. Metsera is developing that treatment as a potential once-monthly injectable, meaning that patients can take it less frequently than existing weekly injections.

Metsera’s pipeline also includes a monthly drug targeting a hormone called amylin, along with two oral GLP-1 candidates “expected to begin trials imminently,” Pfizer said in a release. 

“The proposed acquisition of Metsera aligns with our focus on directing our investments to the most impactful opportunities and propels Pfizer into this key therapeutic area,” Pfizer CEO Albert Bourla said in a statement. “We are excited to apply our deep cardiometabolic experience and manufacturing and commercial infrastructure to accelerate a portfolio that includes potential best-in-class injectables.”

In a note on Monday, Leerink Partners analyst David Risinger said the firm estimates Metsera’s obesity candidates have the potential to generate more than $5 billion in combined peak annual sales. In a separate note on Monday, JPMorgan analyst Chris Schott said Metsera’s experimental drugs “should accelerate” Pfizer’s entry into the market. 

The New York-based Metsera went public this year in one of the biggest biotech listings of 2025. It is among several companies racing to develop next-generation obesity treatments following the success of weekly injections such as Eli Lilly’s obesity drug Zepbound and Novo Nordisk’s rival Wegovy. 



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Full list of Bodycare shops to shut this week after failing to secure a buyer

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Full list of Bodycare shops to shut this week after failing to secure a buyer


All remaining Bodycare shops will shut this week, after the beauty chain’s administrators failed to secure a buyer to keep it on Britain’s high streets.

The chain is set to vanish from Britain’s high streets, with administrators confirming the closure of all 56 remaining stores, leading to approximately 450 redundancies. The beauty retailer entered administration earlier this month, failing to secure a buyer for its UK chain.

Advisory firm Interpath, overseeing the administration, stated that this inability to find a purchaser necessitated the difficult decision to cease trading. Bodycare, established in Lancashire in 1970, specialised in beauty products, fragrances, and various bathroom essentials.

Its outlets were a familiar sight in shopping centres and high streets nationwide. The final closures are anticipated by Saturday, affecting all 444 employees across the stores, who will now face redundancy.

Bodycare will disappear from Britain’s high streets (PA)

These are the locations of the 56 Bodycare stores that will close this week:

Ashton-under-Lyne, Greater Manchester

Banbury, Oxfordshire

Barnsley, South Yorkshire

Barrow-in-Furness, Cumbria

Bedford, Bedfordshire

Blackburn, Lancashire

Blackpool, Lancashire

Braehead, Scotland

Bridgnorth, Shropshire

Burnley, Lancashire

Bury, Greater Manchester

Chorley, Lancashire

Clitheroe, Lancashire

Darlington, Co Durham

Derby, Derbyshire

Dundee, Scotland

Halifax, West Yorkshire

Hereford, Herefordshire

Hinckley, Leicestershire

Irvine, Scotland

Keighley, West Yorkshire

Kendal, Cumbria

Kings Heath, West Midlands

Lancaster, Lancashire

Leeds, West Yorkshire

Leicester, Leicestershire

Leigh, Greater Manchester

Liverpool, Merseyside

Livingston, Scotland

Luton, Bedfordshire

Manchester, Greater Manchester

Merry Hill, West Midlands

Metrocentre, Gateshead, Tyne and Wear

Middlesbrough, North Yorkshire

Mold, Wales

Newcastle, Tyne and Wear

Nuneaton, Warwickshire

Oldham, Greater Manchester

Pontefract, West Yorkshire

Poulton-le-Fylde, Lancashire

Preston, Lancashire

Rugby, Warwickshire

Sheffield, South Yorkshire

Solihull, West Midlands

Sunderland, Tyne and Wear

Sutton Coldfield, West Midlands

Swindon, Wiltshire

Telford, Shropshire

Thurrock, Essex

Trowbridge, Wiltshire

Wakefield, West Yorkshire

Walthamstow, north-east London

Warrington, Cheshire

Washington, Tyne and Wear

Wellingborough, Northamptonshire

Wolverhampton, West Midlands



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Diwali Muhurat Trading 2025: NSE, BSE Announce Timings, Different From Last Year

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Diwali Muhurat Trading 2025: NSE, BSE Announce Timings, Different From Last Year


Last Updated:

The exchange announced that the pre-opening session will take place from 1:30 pm to 1.45 pm

The market will remain closed for regular trading on Diwali, but a special trading window will be open for one hour.

The market will remain closed for regular trading on Diwali, but a special trading window will be open for one hour.

Stock exchanges NSE and BSE will conduct a special Muhurat trading session on Tuesday, October 21, to mark the festival of Diwali, the bourses announced on Monday.

The symbolic trading session will be held between 1:45 pm and 2:45 pm, the stock exchanges said in separate circulars.

Last year, the special Muhurat trading session was held from 6 pm to 7 pm.

The new session also marks the beginning of a new Samvat (Vikram Samvat 2082) — the Hindu calendar year that starts on Diwali — and it is believed that trading during the ‘Muhurat’ or auspicious hour brings prosperity and financial growth for the stakeholders.

The market will remain closed for regular trading on Diwali, but a special trading window will be open for one hour.

The exchange announced that the pre-opening session will take place from 1:30 pm to 1.45 pm.

Market analysts noted that Diwali is considered an auspicious occasion to begin new ventures, and many investors believe participating in the Muhurat trading session brings prosperity throughout the year.

However, with the trading window limited to just an hour, the markets often witness heightened volatility. Analysts added that the significance of the session lies more in its symbolic value than in immediate profitability.

Trading would take place across various segments like equity, commodity derivatives, currency derivatives, equity futures & options, and securities lending & borrowing (SLB) in the same time slot, according to separate circulars issued by the bourses. PTI SP SHW

(This story has not been edited by News18 staff and is published from a syndicated news agency feed – PTI)

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Gold Prices Hit Record Rs 1.11 Lakh per 10 Grams, Silver Tops Rs 1.33 Lakh/kg As Safe-Haven Demand And Weak Rupee Push Bullion To All-Time Highs

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Gold Prices Hit Record Rs 1.11 Lakh per 10 Grams, Silver Tops Rs 1.33 Lakh/kg As Safe-Haven Demand And Weak Rupee Push Bullion To All-Time Highs


New Delhi: Gold prices in India climbed to unprecedented levels on Monday, with futures trading touching Rs 1,11,750 per 10 grams — a fresh all-time high. The December delivery contract on the Multi Commodity Exchange (MCX) rose by Rs 799 (about 0.72 percent) to reach this peak, as investors reacted to global cues including expected US inflation data and remarks from Federal Reserve officials. 

Silver followed suit, with brisk gains across delivery contracts. The March silver futures, for example, surged by Rs 2,446 (nearly 1.86 percent ) to settle at Rs 1,33,582 per kilogram. The December silver contract also breached previous highs, jumping by Rs 2,473 (almost 1.9 percent) to hit Rs 1,32,311/kg. 

Analysts believe several factors are pushing precious metal prices upward:

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A weaker Indian rupee, which makes imports costlier. 

Geopolitical tension and global macroeconomic uncertainty, leading investors to seek safe-haven assets like gold. 

Inflation expectations in the US, along with signals from the Fed about possible future rate cuts. 

Industrial demand boosting silver — especially for applications in solar panels, electronics, EVs and other green technologies. 

Some experts are now forecasting that silver might push toward Rs 1,40,000–Rs 1,50,000 per kg in the near term, depending on supply trends and ongoing demand. 

For now, the current price levels mark a new benchmark in the bullion market — signalling both investor caution and eagerness, as global and domestic forces combine to reshape what was already a strong run upward. 

 



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