Business
Pfizer boosts obesity drug prospects with $7.3 billion deal to buy Metsera
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Pfizer on Monday said it would buy weight loss drugmaker Metsera in an up to $7.3 billion deal, including future payments, as it scrambles to win a slice in the booming obesity drug market.
Pfizer said it will pay an initial $47.50 a share in cash for Metsera, a nearly 43% premium to the biotech company’s Friday’s closing price of $33.32. That gives the deal an enterprise value of $4.9 billion.
The pact also includes a contingent value right worth up to $22.50 a share based on potential clinical and regulatory achievements for Metsera’s medicines, which could bring the total value to $70 a share.
The deal is expected to close at the end of the year. Shares of Metsera rose more than 60% in premarket trading on Monday, while Pfizer’s stock rose more than 1%.
The move comes after a string of setbacks for Pfizer in the obseity space. The pharmaceutical giant struggled to develop its own lead obesity drug candidate, danuglipron, before deciding to scrap it entirely in April due to safety concerns. Pfizer also discontinued a different once-daily pill in June 2023 due to elevated liver enzymes in patients who received it.
Pfizer has earlier-stage obesity drugs in its pipeline that work in different ways, but the company has faced mounting investor pressure to accelerate its push into the market.
The opportunity could be huge. Some analysts expect the weight loss drug space could be worth roughly $100 billion by the 2030s, with room for new rivals to compete with popular injections from Eli Lilly and Novo Nordisk.
Metsera, founded in 2022, brings a pipeline of both oral and injectable treatments with different targets that the company had picked up through its own licensing and acquisition deals. That includes a GLP-1 drug called MET-233i, which helped patients lose up to 8.4% of their weight in 36 days in a small, early-stage trial. Metsera is developing that treatment as a potential once-monthly injectable, meaning that patients can take it less frequently than existing weekly injections.
Metsera’s pipeline also includes a monthly drug targeting a hormone called amylin, along with two oral GLP-1 candidates “expected to begin trials imminently,” Pfizer said in a release.
“The proposed acquisition of Metsera aligns with our focus on directing our investments to the most impactful opportunities and propels Pfizer into this key therapeutic area,” Pfizer CEO Albert Bourla said in a statement. “We are excited to apply our deep cardiometabolic experience and manufacturing and commercial infrastructure to accelerate a portfolio that includes potential best-in-class injectables.”
In a note on Monday, Leerink Partners analyst David Risinger said the firm estimates Metsera’s obesity candidates have the potential to generate more than $5 billion in combined peak annual sales. In a separate note on Monday, JPMorgan analyst Chris Schott said Metsera’s experimental drugs “should accelerate” Pfizer’s entry into the market.
The New York-based Metsera went public this year in one of the biggest biotech listings of 2025. It is among several companies racing to develop next-generation obesity treatments following the success of weekly injections such as Eli Lilly’s obesity drug Zepbound and Novo Nordisk’s rival Wegovy.
Business
Job seekers use AI for cover letters; employers turn to AI-led interviews — both are equally miserable, here’s why – The Times of India
Turned to artificial intelligence (AI) to help you stand out during the job process, but got rejected in the first round? Or are you a hiring manager who relied on AI to frisk through applications to select the best candidate, but ended up with not what you quite envisioned?The answer lies in the approach itself. Relying on artificial intelliegnce for job application might be doing you more harm than good.The growing use of artificial intelligence in recruitment is reshaping how Americans search for work, just as the country’s labour market shows signs of slowing. From automated interviews to AI-written cover letters, technology is now a part of almost every stage of the hiring process. But is it working? In 2025, more than half of organisations surveyed by the Society for Human Resource Management reported using AI tools to recruit workers. At the same time, almost one-third of ChatGPT users turned to the OpenAI chatbot for help with job applications. Yet recent research indicates that candidates who rely on AI during the application process are actually less likely to be hired, even as employers struggle to cope with a flood of applications. “The ability (for companies) to select the best worker today may be worse due to AI,” Anais Galdin, a researcher at Dartmouth told CNN Business. Galdin and Jesse Silbert of Princeton University examined tens of thousands of cover letters submitted on Freelancer.com, a job listing platform and found that after the launch of ChatGPT in 2022, cover letters became longer and more polished. However, employers placed less importance on them, making it harder to distinguish strong candidates from the wider pool. As a result, hiring rates dropped, and so did average starting wages, CNN reported. “If we do nothing to make information flow better between workers and firms, then we might have an outcome that looks something like this,” Silbert said, referring to the study’s findings.
A negative cycle
As application volumes rise, companies are increasingly automating interviews as well.According to a survey by recruitment software firm Greenhouse conducted in October, 54% of US job seekers said they had taken part in an AI-led interview. While virtual interviews became common during the pandemic in 2020, many employers now use AI systems to conduct interviews, without necessarily removing subjectivity from hiring decisions. “Algorithms can copy and even magnify human biases,” said Djurre Holtrop, a researcher who studies the use of asynchronous video interviews, algorithms and large language models in hiring.“Every developer needs to be wary of that,” CNN cited the expert. Daniel Chait, chief executive of Greenhouse, said the growing use of AI by both applicants and employers has created a negative cycle. “Both sides are saying, ‘This is impossible, it’s not working, it’s getting worse,’” Chait told CNN.
What’s next?
Despite these concerns, adoption of the technology continues with one estimate projecting that the market for recruitment technology will grow to $3.1 billion by the end of this year. At the same time, resistance is mounting from lawmakers, labour groups and workers worried about discrimination. Liz Shuler, president of the AFL-CIO labour union, described AI-driven hiring as “unacceptable”. “AI systems rob workers of opportunities they’re qualified for based on criteria as arbitrary as names, zip codes, or even how often they smile,” Shuler said in a statement to CNN. Several US states, including California, Colorado and Illinois, are introducing new laws and regulations aimed at setting standards for the use of AI in hiring. However, a recent executive order signed by US President Donald Trump raised questions about the future of state-level oversight. Samuel Mitchell, a Chicago-based employment lawyer, said the order does not “preempt” state law but adds to the “ongoing uncertainty” around regulation. He added that existing anti-discrimination laws still apply, even when companies use AI systems, and legal challenges are already emerging. In a case supported by the American Civil Liberties Union, a deaf woman is suing HireVue, an AI-powered recruitment company, alleging that an automated interview failed to meet legal accessibility standards. HireVue denied the claim, telling CNN that its technology reduces bias through a “foundation of validated behavioral science”. Even with these challenges, more and more AI is getting hiring access. New tools have made resume screening more sophisticated, potentially helping some candidates who may have been overlooked. But for those who value personal interaction, the shift has been unsettling. Jared Looper, an IT project manager in Salt Lake City, Utah, who previously worked as a recruiter, recently underwent an AI-led interview during his job search. He described the experience as “cold”, and said he initially hung up when contacted by the automated system. Looper said he worries about job seekers who have yet to adapt to a hiring environment where appealing to algorithms has become essential. “Some great people are going to be left behind.”
Business
Christmas spirit offered ‘right through the year’
Caitlin Klein,in Jersey, St Helierand
Julia Gregory,in Jersey
Chris Craddock/BBCA charity which supports vulnerable people in Jersey says it has “the Christmas spirit right through the year”.
The Grace Trust which helps between 700 to 750 people a year struggling with poverty, loneliness or addiction issues said it was seeing “a much wider range” of people from all layers of society, including more older people needing community support.
General manager Vinni Jones said the charity aimed to put a smile on people’s faces from its drop-in base at Lewis Street in St Helier.
It helped 500 people at the food bank every year and also ran singing, art and Saturday lunches.
‘Just come down’
He said there were extra festive goodies at the food bank and 92 people recently sat down to an “absolutely brilliant” Christmas meal at St Paul’s Centre with 20 volunteers on hand to help out.
Entertainment was provided by Fiddler’s Green and the trust’s Parklife choir.
Mr Jones said they saw more people at Christmas because it can be a challenging time.
“Just come down, knock on the window and we’ll give you what we’ve got.”
‘Offer understanding’
He explained that “we can offer a lot more than simply the food and Christmas goodies” and said people are often surprised at all the activities on offer and encouraged them to have a go.
He said the charity also had a fund to help younger mums and links with other agencies so it can offer toy vouchers at Christmas.
Support was also available year round for struggling islanders.
“It’s just a matter of being able to offer that understanding and to talk about January, talk about February for them. We’ll still be here for you,” Mr Jones said.
The government has also reminded islanders about mental health support over Christmas.
There is 24 hour support available from the Adult Mental Health crisis team, on 445 290 and online support from Together All.
Business
‘Made strong entry’: Amit shah hails semiconductor sector’s growth despite being ‘bit late’; confident of ‘exports soon’ – The Times of India
NEW DELHI: India would soon establish itself in the semiconductor industry by starting exports, even though it’s entry was late, said Union home minister Amit Shah.“We have made a strong entry into the semiconductor industry, although a bit late. In no time, we will not only become self-reliant in the semiconductor sector, but will also start exporting it,” he said, addressing the ‘Abhyudaya Madhya Pradesh Growth Summit’.Speaking at the summit, Shah highlighted Madhya Pradesh’s attractive geographical location and fertile land.He also inaugurated industrial projects worth Rs 2 lakh crore, on the occasion of former Prime Minister Atal Bihari Vajpayee‘s 101st birth anniversary. He remembered Vajpayee as “a great orator, a sensitive poet, a leader dedicated to public welfare and remained ‘ajatashatru’ (person without enemies) in politics.”He noted that even small investments in the state could yield substantial returns. He praised Madhya Pradesh’s transformation from a power-deficient state to one with surplus electricity. He also commended the state’s achievements in cleanliness, saying it has surpassed other states in this aspect.During the event, Shah also paid tributes to Pandit Madan Mohan Malviya on his birth anniversary and C Rajagopalachari on his death anniversary. The Growth Summit attracted 25,000 beneficiaries and thousands of entrepreneurs and investors. Officials confirmed that the industrial projects launched during the event will create 193,000 new jobs.Shah’s visit also included inaugurating the Gwalior Fair and dedicating the renovated Atal Museum to the public, further marking the celebrations of Vajpayee’s birth anniversary.
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