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Weight-Loss Drug Zepbound Is Being Tested as a Treatment for Long Covid

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Weight-Loss Drug Zepbound Is Being Tested as a Treatment for Long Covid


Obesity wonder drugs Wegovy and Zepbound are already showing that they can reduce the risk of cardiovascular and chronic kidney disease in addition to helping people lose weight. Now, a US-wide trial will test whether tirzepatide, the active ingredient in Zepbound, may be an effective treatment for people with long Covid.

Part of a class of drugs known as GLP-1s, tirzepatide acts on receptors in the gut and the brain to regulate appetite. As a result, people shed pounds by eating less. But decreased body weight doesn’t fully explain the positive effects on the heart and kidney. Mounting evidence suggests that the drugs have a broad anti-inflammatory effect on the body—a mechanism that’s of interest for treating long Covid.

As many as 20 million people in the US have experienced long Covid, a chronic condition that lasts for at least three months after an initial infection. While more than 200 symptoms of long Covid have been documented, some of the most common include coughing, shortness of breath, brain fog, fatigue, mood changes, trouble sleeping, and body aches.

Scientists still don’t fully understand how and why long Covid occurs, but they’ve found persistent inflammation in many patients. This chronic inflammation may be caused by lingering traces of virus in the body or by misdirected antibodies, known as autoantibodies, that attack a person’s own cells and tissues. The hope is that tirzepatide could tamp down this inflammation to improve patients’ symptoms.

“The rationale for a GLP-1 drug is its powerful body-wide and brain anti-inflammatory properties,” says Eric Topol, a cardiologist and the director of the La Jolla, California-based Scripps Research Translational Institute, which is sponsoring the trial.

Scripps researchers are recruiting 1,000 people across the country who are 18 years of age or older and have medical documentation of long Covid. Unlike most medical studies, which typically require multiple in-person visits, the Scripps trial is fully remote. Participants will be randomized to receive either tirzepatide or a placebo by mail and will take it for a year. They’ll receive a fitness tracker so that researchers can measure their step count, an important indicator of fatigue. Participants will also get a smart scale and will weigh in regularly. Since GLP-1s are used for weight management, study investigators want to make sure participants don’t lose too much weight during the trial.

Julia Moore Vogel, coprincipal investigator of the trial who herself has long Covid, says the remote design of the trial was intentional. “For the long Covid population, it’s so crucial, because if you’re requiring people to come into a clinic, you’re systematically excluding the most severely affected folks who are housebound or bedbound. It was really important to us to make sure that those people are included.”



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No Bad Weather: Stay Warm by Dressing in Layers

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No Bad Weather: Stay Warm by Dressing in Layers


Layering is not complicated. It’s the process of adding and removing layers of clothing to keep your body comfortable in changing weather and temperature conditions.

Billions of dollars have been spent trying to optimize this process (and sell you stuff), but it’s really very simple: Put clothing on when you’re cold, take clothing off when you’re hot. Which clothing? That’s the rub, as they say. But don’t worry. We’ll walk you through what each layer is, how to layer, and when you’ll want it. Once you’re done here, check out our guides to the Best Base Layers, Best Puffer Jackets, Best Merino Wool, and Best Rain Jackets for more.

Updated February 2026: We’ve updated our advice based on new experiences, and put in a few new picks culled from all the gear we’ve tested in the last year.

Layering Basics

Photograph: Carol Yepes/Getty Images

The key to layering is knowing what the layers are for and when to add and remove them. The high level overview looks like this:

  • Base layer: The layer that touches your skin. These provide some warmth, but they’re primarily important for wicking sweat away from your skin. Being damp means being cold.
  • Mid layer: The layer that’s—wait for it—in the middle. This is the layer where you actually start insulating, or trapping body heat. This is the key to the whole system and should usually be more than one layer (e.g., a lightweight fleece and a puffer jacket).
  • Outer layer: The top layer is the waterproof, windproof layer that makes sure that nature does not steal all that precious heat you’ve retained in the mid layer. This is sometimes referred to as a “shell.”

While you won’t always be wearing all of these, especially when you’re exerting yourself while walking, running, et cetera, it’s usually worth carrying all three. If it’s cold, you can start with all three on and peel them off as you get warmer. When it’s hot you can do the opposite, pulling out a shell when you stop on a windy ridge. Obviously there are situations where you don’t need to carry all of them. Hiking the Florida trail in July? Skip the mid layer, ya lunatic.

Base Layers

Smartwool all season merino long sleeve t-shirt in green

SmartWool

Merino Classic Long-Sleeve

Let’s start with underwear. Whether boxers, briefs, boxer briefs, or bras, go for materials that are going to help move moisture away from your skin. I have found merino wool to be ideal for underwear, but it’s worth trying different fabrics to find which works best for you.

Next comes what we generally think of as base layers: relatively tight-fitting but not overly restrictive pants and shirt with the dual purpose of insulating in cold weather and wicking sweat in hot. Again, there is a wide array of fabrics. If you opt for merino wool here, you benefit from wool’s natural ability to smooth out temperature variation across your skin, keeping you more evenly warm/cool (I call this temperature modulation).

There are also other options for fabric here, which includes Nuyarn. It has much of the benefits of merino (it’s usually more than half merino) but adds some nylon to provide extra strength and durability, as well as speeding up drying times. The latter can be important in very wet climates. In my experience, synthetic base layers do not perform as well at either insulation or moisture removal, though they will often dry faster, last longer, and are often cheaper.



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WBA publishes initial guidance on artificial intelligence, machine learning for intelligent Wi-Fi | Computer Weekly

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WBA publishes initial guidance on artificial intelligence, machine learning for intelligent Wi-Fi | Computer Weekly


The Wireless Broadband Alliance (WBA) has published a report outlining an industry-wide perspective for device manufacturers, network operators, enterprise IT and policymakers on how artificial intelligence (AI) and machine learning (ML) can be integrated across the full Wi-Fi ecosystem.

The AI/ML for Wi-Fi: Enabling scalable, intelligent Wi-Fi ecosystems report was developed by the WBA AI/ML for Wi-Fi Project Group, and led by Intel with Airties, Cisco and HPE.

The founding viewpoint from the WBA is that traditional rule‑based management approaches for Wi‑Fi technology are no longer adequate as they are now asked to support increasingly support demanding applications such as enterprise collaboration, industrial automation, immersive media and AI workloads. The report outlines business benefits including lower operational costs, stronger reliability and security, and an improved user experience.

The report shows how AI and ML are becoming foundational to Wi-Fi, enabling a shift from reactive troubleshooting to predictive, proactive and self-optimising network operations capable of managing dense deployments and real-time performance demands.

In addition, it highlights how intelligent Wi-Fi has clear business value. AI/ML reduces operational costs (OpEx), improves reliability and security, and delivers a more consistent quality of experience (QoE). Moreover, the report argues that AI will not just sit at the router: instead, it will combine client, access point, edge and cloud intelligence to achieve the best performance.

However, it also observed that data is the primary bottleneck, and that achieving continued success and new use cases with AI/ML in networks requires shared datasets, federated learning and strong governance models. Fragmentation also remains a major barrier.

Going forward, WBA advises that standardisation should focus on frameworks and not algorithms. It added that interoperability will need to include data models, telemetry, application programming interfaces and model lifecycle management. WBA also believes that AI/ML-native Wi-Fi is the long-term technological direction and that features of Wi-Fi 8 (IEEE 802.11bn), such DBE and MAPC, will work optimally when driven by an AI/ML engine.

Commenting on the report, Tiago Rodrigues, Wireless Broadband Alliance president and CEO, said: “Wi-Fi is now expected to perform like critical infrastructure across homes, enterprises and cities, yet operational complexity is rising fast. AI and machine learning are becoming essential to keep networks reliable, secure and efficient at scale. The industry must align on common data, interfaces and governance, so that intelligent Wi-Fi can work across real-world multi-vendor environments and deliver value for all who use it.”

Matthew MacPherson, wireless chief technology officer at Cisco, added: “As Wi-Fi becomes the primary connectivity technology for mission-critical enterprise applications, the complexity of managing these environments has outpaced traditional manual methods.

“This report provides a vital framework for the industry to transition from reactive troubleshooting to a proactive, self-optimising architecture,” he said. “By leveraging AI and machine learning through interoperable standards, we are enabling organisations to reduce operational overheads and deliver a more resilient, high-quality experience for every user and device.”

Eric McLaughlin, vice-president and general manager of Intel, said: “AI/ML is transforming the future of Wi-Fi, and it has become a strategic imperative. We are excited to collaborate with our WBA partners and the broader ecosystem to accelerate its advancement to enable self-organising, proactive, and more reliable networks with improved QoE across the industry.”



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H&R Block Coupon: $50 Off In-Store Services

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H&R Block Coupon:  Off In-Store Services


As they say, the only things you can’t escape in life are death and taxes. Doing your own taxes has only gotten easier over the years but it’s still plenty confusing, especially with both federal and state rules and rates always in flux. To help you figure out this confusing process, I’ve written a guide on How to Pay Your Taxes Online, and included H&R Block and other competitors to give you more information as you navigate between the seemingly endless options available for your specific tax needs. Tax day may not be until April 15 but as we all know too well, that date comes around quickly each year. With that in mind, now’s a great time to start getting your affairs in order.

For 70 years, H&R Block has stepped in to help with tax preparation services that aim to make things as painless as possible. H&R Block has its classic in-person help from a tax expert along with easy-to-use online tax services that you can complete online while in your pajamas. We here at WIRED love to help you save money too, and that’s why we have rotating deals and H&R Block coupons to help ease the pain of tax season a little more.

Save With Our $50 H&R Block In-Store Coupon (And More)

To help make tax season a bit more bearable, you can get $50 off in-person tax prep when you file with an H&R Block tax pro (until February 23). To redeem this offer, you’ll need to make an appointment online, and present the coupon either digitally or in-print. This coupon features single-use codes, so you’ll need to click on the module at the top of the page to get the H&R Block discount code (and you can’t use the same one twice). Also through February 23, you can also get 25% off H&R Block’s DIY online offering, with no promo code needed!

Can I File My Taxes for Free at H&R Block?

H&R Block knows taxes are confusing, and the process is one that no filer looks forward to. That’s why H&R Block eases some of the tax filing woes by offering H&R Block Online Free Edition. Over half (around 55% of filers) qualify; this service is for simple taxes only, meaning Form 1040s and no schedules except Earned Income Tax Credit, Child Tax Credit, Student Loan Interest, and Retirement Plan Distributions. File your simple state return for free on H&R Block today.

Don’t Go at it Alone With H&R Block Assistance Options

Tax assist options are available, whatever your need. Not a CPA or DIY-er? No problem. H&R Block’s tax experts are trained and ready to help with big and small tax questions. There are tons of choices, no matter your need, like a one-on-one meeting in an office where you can make an appointment ahead of time, or just walk in; from home where you can work with your Tax Pro online; and you can even drop off files at an H&R Block office. Plus, you can even get a free Second Look Review of past returns to see if there was money left on the table.

Get Up to $4,000 With a Refund Advance Loan at H&R Block

If you can’t wait on your refund (no judgement; I get it), you can get up to $4,000 in refunds immediately after filing, without waiting for the slow-moving federal and state processes. If eligible, you can get a Refund Advance loan within minutes of filing when you complete the process with an H&R Block Tax Pro. With this loan advance, there’s no loan fees or interest. Act sooner rather than later, as this deal is only available through March 15.

How Much Does H&R Block Charge?

H&R Block has different tiers depending on tax filing needs, so you can pick the online filing option that works best for you. The free online is best for simple returns, with $0 per state filed; deluxe starts at $28 for federal and $37 per state filed, which includes itemized deductions and free tax Pro review. Premium is now only $56 and $37 per state filed, and also includes investments and free tax Pro review. Plus, they have an option for self-employed folks and business owners, whose taxes can be complicated and costly. That service includes 1099 forms with expenses and includes free tax Pro reviews, and costs $68 right now with $37 per state filed.

How Do I Get an H&R Block Key Code?

An H&R Block Activation Code is a unique ten-character code that’s attached to your personal H&R Block Tax Software. It’ll be a long string of uppercase letters and numbers. This activation code registers your software and is used to unlock your five free federal e-files. Once opened, you’ll need to enter it to activate the software. More in-depth directions and troubleshooting can be found here.

Other Deals for New and Existing H&R Block Customers

To find which service best fits your needs, select all that apply to you—like if you have kids, own a home, or are a freelancer—to find your best personal filing experience. H&R Block has four different packages, including federal and state. Best of all, you can save 20% on H&R Block tax software products without an H&R Block promo code (until April 15).

H&R Block has tons of incentives and perks, including a free 3-year Second Look. That means H&R Block will review your last three tax returns to find errors, mistakes, or money others may have missed. Get your taxes done and spend the rest of the spring chilling; DIY online file, or get an in-store assisted file for less—no H&R Block coupon needed.



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