Altra Running’s distinctive wide toe box and zero drop heel-toe design don’t facilitate marathon PRs or punchy 5Ks. But there’s a reason why Leonardo DiCaprio chose to wear all-weather Lone Peaks when playing Bob Ferguson in One Battle After Another. They’re comfortable, rugged, and the zero-drop design keeps you from getting tendonitis. Altras are the perfect shoe for surviving in an off-grid dystopian war, even if they’re not at the top of the list when it comes to the best running shoes.

Get Up to 50% Off at the Altra Running Sale

The Lone Peaks are iconic and instantly recognizable. But don’t worry, if you don’t want the exact model that Bob Ferguson has, the hiking version of the Lone Peaks is also on sale for $36 off. In fact, there are tons of different styles of men’s shoes right now, including up to 50% off select styles.

Save 20% on Select Altra Running Shoes

Maybe you’re investigating Altra running shoes because a more widely-known brand, like Brooks or Nike, has a toe box that’s just too small. In that case, Altra doesn’t exclusively make trail running shoes. The Fwd Via is Altra’s version of the Brooks Glycerin—the ultra-cushioned road running shoe. It’s also on sale, along with various running shoes at 20% off.

Unlock 15% Off: SMS Welcome Offer

One of the easiest ways to save at Altra running is to sign up for text messages from them. Once you sign up, you’ll receive an Altra SMS welcome offer that’s good for 15% off your next purchase. Once you receive it and you’re ready to buy, you’ll just need to input the Altra promo code at checkout, and click “Apply A Promo Code.” just know that the Altra promo code is valid for only 30 days after you receive and is valid for a one-time use only. (Plus, it’s not valid at any third party retail store or website.)

Get a 10% Altra Promo Code When You Sign Up

I have run in a model of the Altra Lone Peaks for a decade. Where I live is the unofficial trail running capital of the United States, and everyone sports a pair of these shoes while hiking or at the bar. It’s totally worth it to sign up for the loyalty program and get the Altra Running promo code. (I also do this with my children, who exclusively wear Salomons.) When you sign up for the Altra loyalty program, you’ll get 10% off as a thank you.

10% Off Altra Olympus 275

The Altra Olympus 275 for both men and women just may be the hottest trail running shoe of the season. The Altra Olympus 275 is best for technical trail and all-day trail running, with increased durability, protection, and lightweight construction to face the toughest trails. Plus, it has a custom-designed MATRYX one-piece woven upper that’s both lightweight and protective. A grippyVibram Megagrip outsole helps with traction on wet and dry surfaces to ensure that no matter what type of terrain or weather conditions you encounter on the trail, you’ll be set. Plus, when you sign up to be an Altra member, you’ll get 10% off your Altra Olympus 275 pair.

Score Free Standard Shipping on All Altra Orders

You can get free standard delivery in 5-7 business days (however, there’s no weekend delivery) for free when you order through Altra! If you need your shoes in a rush, there’s 2-day shipping (with no weekend delivery) for $16.95, and next-day delivery (Saturday and Sunday orders ship on Mondays) for $22.

Shop the New Altra Running Shoes

Altra Running has just dropped their new line in time for winter, The Frozen Coast Collection, with colorways inspired by the beautiful, icy tundra of Iceland. Some running shoes we’ve been eyeing in this collection include the Lone Peak 9+, with Vibram Megagrip outsole for fierce grip and midsole foam for a comfortable connection to the ground below. And there’s also the 9+ GTX, also equipped with a Vibram Megagrip outsole that gives tons of traction in wet or dry conditions, an Altra EGO midsole for extra cushion, and a shortened toe cap for extended flexibility, whether you’re hiking or trail running.

The Ember Smart Mug 2 is niche, but it has a loyal following. Even though we think there are better mug warmers on the market, Ember is like Apple AirPods or Kleenex. People want what they want. Right now, for Mother’s Day, the Ember Smart Mug 2 is on sale for just under $100, a 30 percent discount and a match of the very best price we’ve tracked. You can save at Amazon, Best Buy, and the manufacturer’s website.

This smart mug is probably overkill. It has a smartphone app that notifies you when your coffee reaches the ideal temperature, and its onboard light also provides a visual indicator that your brew is ready. It intelligently adjusts power usage to keep your drink warm when you’re nearby, and turns off when you’re not around. The self-heating mug is on sale in a few variations—10 or 14 ounces, in blue, white, black, and purple.

The mug offers up to 80 minutes of powered heating time, or you can pop it on the included charging coaster to keep the battery going all day. And you don’t need the smartphone app unless you want to precisely dictate your coffee temperature—the mug defaults to 135 degrees Fahrenheit without your specific input.

Our main gripe is that this proprietary warming system is not dishwasher safe. You need to hand-wash each component, and ensure you do so carefully, because the items are not cheap to replace. But if Mom has been putzing around the house drinking perpetually microwaved coffee, perhaps an upgrade is in order. We have additional recommendations in our guide to the Best Coffee Warmers. You may also want to check our related stories on the Best Espresso Machines, Best Coffee Machines, and Best Pod Coffee Makers.

Google DeepMind’s AlphaFold has already revolutionized scientists’ understanding of proteins. Now, the ability of the platform to design safe and effective drugs is about to be put to the test.

Isomorphic Labs, the UK-based biotech spinoff of Google DeepMind, will soon begin human trials of drugs designed by its Nobel Prize–winning AI technology. “We’re gearing up to go into the clinic,” Isomorphic Labs president Max Jaderberg said on April 16 at WIRED Health in London. “It’s going to be a very exciting moment as we go into clinical trials and start seeing the efficacy of these molecules.”

Jaderberg did not elaborate on the timeline, but it’s later than the company had planned to initiate human studies. Last year, CEO Demis Hassabis said it would have AI-designed drugs in clinical trials by the end of 2025.

Isomorphic Labs was founded in 2021 as a spinoff from Alphabet’s AI research subsidiary, Google DeepMind. The company uses DeepMind’s AlphaFold, a groundbreaking AI platform that predicts protein structures, for drug discovery.

Built from 20 different amino acids, proteins are essential for all living organisms. Long strings of amino acids link together and fold up to make a protein’s three-dimensional structure, which dictates the protein’s function. Researchers had tried to predict protein structures since the 1970s, but this was a painstaking process given the astronomically high number of possible shapes a protein chain can take.

That changed in 2020, when DeepMind’s Hassabis and John Jumper presented stunning results from AlphaFold 2, which uses deep-learning techniques. A year later, the company released an open-source version of AlphaFold available to anyone.

In 2024, DeepMind and Isomorphic Labs released AlphaFold 3, which advanced scientists’ understanding of proteins even further. It moved beyond modeling proteins in isolation to predicting other important molecules, such as DNA and RNA, and their interactions with proteins.

“This is exactly what you need for drug discovery: You need to see how a small molecule is going to bind to a drug, how strongly, and also what else it might bind to,” Hassabis told WIRED at the time.

Since its release, the AlphaFold platform has been able to predict the structure of virtually all the 200 million proteins known to researchers and has been used by more than 2 million people from 190 countries. The breakthrough earned Hassabis and Jumper the Nobel Prize for chemistry in 2024, with the Nobel committee noting that AlphaFold has enabled a number of scientific applications, including a better understanding of antibiotic resistance and the creation of images of enzymes that can decompose plastic.

Earlier this year, Isomorphic Labs announced an even more powerful tool, what it calls IsoDDE, its proprietary drug-design engine. In a technical paper, the company touts that the platform more than doubles the accuracy of AlphaFold 3.

The startup has formed partnerships with Eli Lilly and Novartis to work together on AI drug discovery and is also advancing its own “broad and exciting pipeline of new medicines” in oncology and immunology, Jaderberg said.

“The exciting thing about the molecules that we’re designing is because we have so much more of an understanding about how these molecules work, we’ve engineered them to be very, very potent,” Jaderberg told the audience at WIRED Health. “You can take them at a much lower dose, and they’ll have lower side effects, off target effects.”

Last year, Isomorphic appointed a chief medical officer and announced it had raised $600 million in its first funding round to gear up for clinical trials. Meanwhile, the company has been building a clinical development team. Its mission is to “solve all disease.”

“It’s a crazy mission,” Jaderberg said. “But we really mean it. We say it with a straight face, because we believe this should be possible.”