Tech
Jennifer Lewis ScD ’91: “Can we make tissues that are made from you, for you?”
“Can we make tissues that are made from you, for you?” asked Jennifer Lewis ScD ’91 at the 2025 Mildred S. Dresselhaus Lecture, organized by MIT.nano, on Nov. 3. “The grand challenge goal is to create these tissues for therapeutic use and, ultimately, at the whole organ scale.”
Lewis, the Hansjörg Wyss Professor of Biologically Inspired Engineering at Harvard University, is pursuing that challenge through advances in 3D printing. In her talk presented to a combined in-person and virtual audience of over 500 attendees, Lewis shared work from her lab that focuses on enhanced function in 3D printed components for use in soft electronics, robotics, and life sciences.
“How you make a material affects its structure, and it affects its properties,” said Lewis. “This perspective was a light bulb moment for me, to think about 3D printing beyond just prototyping and making shapes, but really being able to control local composition, structure, and properties across multiple scales.”
A trained materials scientist, Lewis reflected on learning to speak the language of biologists when she joined Harvard to start her own lab focused on bioprinting and biological engineering. How does one compare particles and polymers to stem cells and extracellular matrices? A key commonality, she explained, is the need for a material that can be embedded and then erased, leaving behind open channels. To meet this need, Lewis’ lab developed new 3D printing methods, sophisticated printhead designs, and viscoelastic inks — meaning the ink can go back and forth between liquid and solid form.
Displaying a video of a moving robot octopus named Octobot, Lewis showed how her group engineered two sacrificial inks that change from fluid to solid upon either warming or cooling. The concept draws inspiration from nature — plants that dynamically change in response to touch, light, heat, and hydration. For Octobot, Lewis’ team used sacrificial ink and an embedded printing process that enables free-form printing in three dimensions, rather than layer-by-layer, to create a fully soft autonomous robot. An oscillating circuit in the center guides the fuel (hydrogen peroxide), making the arms move up and down as they inflate and deflate.
From robots to whole organ engineering
“How can we leverage shape morphing in tissue engineering?” asked Lewis. “Just like our blood continuously flows through our body, we could have continuous supply of healing.”
Lewis’ lab is now working on building human tissues, primarily cardiac, kidney, and cerebral tissue, using patient-specific cells. The motivation, Lewis explained, is not only the need for human organs for people with diseases, but the fact that receiving a donated organ means taking immunosuppressants the rest of your life. If, instead, the tissue could be made from your own cells, it would be a stronger match to your own body.
“Just like we did to engineer viscoelastic matrices for embedded printing of functional and structural materials,” said Lewis, “we can take stem cells and then use our sacrificial writing method to write in perfusable vasculature.” The process uses a technique Lewis calls SWIFT — sacrificial writing into functional tissue. Sharing lab results, Lewis showed how the stem cells, differentiated into cardiac building blocks, are initially beating individually, but after being packed into a tighter space that will support SWIFT, these building blocks fuse together and become one tissue that beats synchronously. Then, her team uses a gelatin ink that solidifies or liquefies with temperature changes to print the complex design of human vessels, flushing away the ink to leave behind open lumens. The channel remains open, mimicking a blood vessel network that could have fluid actively, continuously flowing through it. “Where we’re going is to expand this not only to different tissue types, but also building in mechanisms by which we can build multi-scale vasculature,” said Lewis.
Honoring Mildred S. Dresselhaus
In closing, Lewis reflected on Dresselhaus’ positive impact on her own career. “I want to dedicate this [talk] to Millie Dresselhaus,” said Lewis. She pointed to a quote by Millie: “The best thing about having a lady professor on campus is that it tells women students that they can do it, too.” Lewis, who arrived at MIT as a materials science and engineering graduate student in the late 1980s, a time when there were very few women with engineering doctorates, noted that “just seeing someone of her stature was really an inspiration for me. I thank her very much for all that she’s done, for her amazing inspiration both as a student, as a faculty member, and even now, today.”
After the lecture, Lewis was joined by Ritu Raman, the Eugene Bell Career Development Assistant Professor of Tissue Engineering in the MIT Department of Mechanical Engineering, for a question-and-answer session. Their discussion included ideas on 3D printing hardware and software, tissue repair and regeneration, and bioprinting in space.
“Both Mildred Dresselhaus and Jennifer Lewis have made incredible contributions to science and served as inspiring role models to many in the MIT community and beyond, including myself,” said Raman. “In my own career as a tissue engineer, the tools and techniques developed by Professor Lewis and her team have critically informed and enabled the research my lab is pursuing.”
This was the seventh Dresselhaus Lecture, named in honor of the late MIT Institute Professor Mildred Dresselhaus, known to many as the “Queen of Carbon Science.” The annual event honors a significant figure in science and engineering from anywhere in the world whose leadership and impact echo Dresselhaus’ life, accomplishments, and values.
“Professor Lewis exemplifies, in so many ways, the spirit of Millie Dresselhaus,” said MIT.nano Director Vladimir Bulović. “Millie’s groundbreaking work, indeed, is well known; and the groundbreaking work of Professor Lewis in 3D printing and bio-inspired materials continues that legacy.”
Tech
Onnit’s Instant Melatonin Spray Is the Easiest Part of My Nightly Routine
I’ve always approached taking melatonin supplements with skepticism. They seem to help every once in a while, but your brain is already making melatonin. Beyond that, I am not a fan of the sickly-sweet tablets, gummies, and other forms of melatonin I’ve come across. No one wants a bad taste in their mouth when they’re supposed to be drifting off to sleep.
This is where Onnit’s Instant Melatonin Spray comes in. Fellow WIRED reviewer Molly Higgins first gave it a go, and reported back favorably. This spray comes in two flavors, lavender and mint, and is sweetened with stevia. While I wouldn’t consider it a gourmet taste, I appreciate that it leans more into herbal components known for sleep and relaxation.
Keep in mind that melatonin is meant to be a sleep aid, not a cure-all. That being said, one serving of this spray has 3 milligrams of melatonin, which takes about six pumps to dispense. While 3 milligrams may not seem like a lot to really kickstart your circadian rhythm, it’s actually the ideal dosage to get your brain’s wind-down process kicked off. Some people can do more (but don’t go over 10 milligrams!), some less, but based on what experts have relayed to me, this is the preferable amount.
A couple of reminders for any supplement: consult your doctor if and when you want to incorporate anything, melatonin included, into your nighttime regimen. Your healthcare provider can help confirm that you’re not on any medications where adding a sleep aid or supplement wouldn’t feel as effective. Onnit’s Instant Melatonin Spray is International Genetically Modified Organism Evaluation and Notification certified (IGEN) to verify that it uses truly non-GMO ingredients.
Apart from that, there may be some trial and error on the ideal amount for you, and how much time it takes to kick in. Some may feel the melatonin sooner than others. For my colleague Molly, it took about an hour. Melatonin can’t do all the heavy lifting, so make sure you’re ready to go to bed when you take it, and that your sleep space is set up for sleep success, down to your mattress, sheets, and pillows.
Tech
I Tested Bosch’s New Vacuum Against Shark and Dyson. It Didn’t Beat Them
There’s a lever on the back for this compression mechanism that you manually press down and a separate button to open the dustbin at the bottom. You can use the compression lever when it’s both closed and open. It did help compress the hair and dust while I was vacuuming, helping me see if I had really filled the bin, though at a certain point it doesn’t compress much more. It was helpful to push debris out if needed too, versus the times I’ve had to stick my hand in both the Dyson and Shark to get the stuck hair and dust out. Dyson has this same feature on the Piston Animal V16, which is due out this year, so I’ll be curious to see which mechanism is better engineered.
Bendable Winner: Shark
Photograph: Nena Farrell
If you’re looking for a vacuum that can bend to reach under furniture, I prefer the Shark to the Bosch. Both have a similar mechanism and feel, but the Bosch tended to push debris around when I was using it with an active bend, while the Shark managed to vacuum up debris I couldn’t get with the Bosch without lifting it and placing it on top of that particular debris (in this case, rogue cat kibble).
Accessory Winner: Dyson
Dyson pulls ahead because the Dyson Gen5 Detect comes with three attachments and two heads. You’ll get a Motorbar head, a Fluffy Optic head, a hair tool, a combination tool, and a dusting and crevice tool that’s actually built into the stick tube. I love that it’s built into the vacuum so that it’s one less separate attachment to carry around, and it makes me more likely to use it.
But Bosch does well in this area, too. You’ll get an upholstery nozzle, a furniture brush, and a crevice nozzle. It’s one more attachment than you’ll get with Shark, and Bosch also includes a wall mount that you can wire the charging cord into for storage and charging, and you can mount two attachments on it. But I will say, I like that Shark includes a simple tote bag to store the attachments in. The rest of my attachments are in plastic bags for each vacuum, and keeping track of attachments is the most annoying part of a cordless vacuum.
Build Winner: Tie
Photograph: Nena Farrell
All three of these vacuums have a good build quality, but each one feels like it focuses on something different. Bosch feels the lightest of the three and stands up the easiest on its own, but all three do need something to lean against to stay upright. The Dyson is the worst at this; it also needs a ledge or table wedged under the canister, or it’ll roll forward and tip over. The Bosch has a sleek black look and a colorful LED screen that will show you a picture of carpet or hardwood depending on what mode it’s vacuuming in. The vacuum head itself feels like the lightest plastic of the bunch, though.
Tech
Right-Wing Gun Enthusiasts and Extremists Are Working Overtime to Justify Alex Pretti’s Killing
Brandon Herrera, a prominent gun influencer with over 4 million followers on YouTube, said in a video posted this week that while it was unfortunate that Pretti died, ultimately the fault was his own.
“Pretti didn’t deserve to die, but it also wasn’t just a baseless execution,” Herrera said, adding without evidence that Pretti’s purpose was to disrupt ICE operations. “If you’re interfering with arrests and things like that, that’s a crime. If you get in the fucking officer’s way, that will probably be escalated to physical force, whether it’s arresting you or just getting you the fuck out of the way, which then can lead to a tussle, which, if you’re armed, can lead to a fatal shooting.” He described the situation as “lawful but awful.”
Herrera was joined in the video by former police officer and fellow gun influencer Cody Garrett, known online as Donut Operator.
Both men took the opportunity to deride immigrants, with Herrera saying “every news outlet is going to jump onto this because it’s current thing and they’re going to ignore the 12 drunk drivers who killed you know, American citizens yesterday that were all illegals or H-1Bs or whatever.”
Herrera also referenced his “friend” Kyle Rittenhouse, who has become central to much of the debate about the shooting.
On August 25, 2020, Rittenhouse, who was 17 at the time, traveled from his home in Illinois to a protest in Kenosha, Wisconsin, brandishing an AR-15-style rifle, claiming he was there to protect local businesses. He killed two people and shot another in the arm that night.
Critics of ICE’s actions in Minneapolis quickly highlighted what they saw as the hypocrisy of the right’s defense of Rittenhouse and attacks on Pretti.
“Kyle Rittenhouse was a conservative hero for walking into a protest actually brandishing a weapon, but this guy who had a legal permit to carry and already had had his gun removed is to some people an instigator, when he was actually going to help a woman,” Jessica Tarlov, a Democratic strategist, said on Fox News this week.
Rittenhouse also waded into the debate, writing on X: “The correct way to approach law enforcement when armed,” above a picture of himself with his hands up in front of police after he killed two people. He added in another post that “ICE messed up.”
The claim that Pretti was to blame was repeated in private Facebook groups run by armed militias, according to data shared with WIRED by the Tech Transparency Project, as well as on extremist Telegram channels.
“I’m sorry for him and his family,” one member of a Facebook group called American Patriots wrote. “My question though, why did he go to these riots armed with a gun and extra magazines if he wasn’t planning on using them?”
Some extremist groups, such as the far-right Boogaloo movement, have been highly critical of the administration’s comments on being armed at a protest.
“To the ‘dont bring a gun to a protest’ crowd, fuck you,” one member of a private Boogaloo group wrote on Facebook this week. “To the fucking turn coats thinking disarming is the answer and dont think it would happen to you as well, fuck you. To the federal government who I’ve watched murder citizens just for saying no to them, fuck you. Shall not be infringed.”
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