Business
Nifty Prediction For December 1: Can Bulls Extend Their Grip Next Week? Check Support, Resistance
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Sensex, Nifty ended nearly flat after record highs as markets turn cautious ahead of RBI policy, US data, auto sales and key global triggers
Nifty Prediction For December 1
Nifty Prediction For Next Week: Indian equity benchmarks ended almost flat in a highly volatile session on Friday, November 29, a day after hitting fresh record highs. Breaking a two-day winning streak, the BSE Sensex slipped 13.71 points, or 0.02 per cent, to close at 85,706.67. During the session, it touched an intra-day high of 85,969.89 and a low of 85,577.82. The NSE Nifty50 also edged lower by 12.60 points, or 0.05 per cent, to settle at 26,202.95.
On Thursday, both benchmark indices had scaled fresh lifetime highs after a gap of 14 months, with the Sensex touching 86,055.86 and the Nifty hitting 26,310.45 in intraday trade. On a weekly basis, the Sensex gained 474.75 points, or 0.55 per cent, while the Nifty advanced 134.80 points, or 0.51 per cent.
Sensex Outlook: Key Levels to Watch
Technically, 86,045 remains the immediate resistance for the Sensex. A breakout above this level could pave the way for a fresh rally, while a fall below 85,500 may trigger further short-term weakness. Hitesh Tailor, Research Analyst at Choice Equity Broking, said the Sensex may consolidate in the coming week after reaching record highs. He sees immediate resistance at 86,000, with fresh buying likely on a decisive close above this level. On the downside, the 85,200–85,300 zone is expected to act as strong near-term support.
Top Five Triggers for the Indian Stock Market This Week
RBI Monetary Policy Meeting
The Reserve Bank of India’s Monetary Policy Committee, led by Governor Sanjay Malhotra, will meet from December 3 to 5, with the repo rate decision due on December 5. The RBI has kept the repo rate unchanged at 5.5 per cent since August after cutting it by a cumulative 100 basis points in the first half of the year. Market participants will closely track commentary on inflation, growth and the future rate-cut outlook.
Auto Sales Data
November automobile sales figures, scheduled for release on December 1, will be in sharp focus. Strong sales across passenger vehicles, two-wheelers and commercial vehicles could revive demand optimism, while weaker numbers may raise concerns over margins and rural consumption.
Key US Economic Data
Wall Street faces a full trading week, though data releases remain relatively light. Investors will track the delayed September reading of the Federal Reserve’s preferred inflation gauge. The ADP National Employment Report for November will be released on Wednesday, while the Bureau of Economic Analysis will publish the delayed PCE and Core PCE inflation data on Friday.
India–US Trade Deal
India is expected to finalise a trade agreement with the United States by the end of the year, as most unresolved issues have been settled, according to the country’s trade secretary. US President Donald Trump earlier said talks with Prime Minister Narendra Modi were progressing well. However, the US has imposed tariffs of up to 50 per cent on Indian imports since late August.
FII and DII Activity
On Friday, Foreign Institutional Investors sold equities worth Rs 3,795.72 crore, while Domestic Institutional Investors purchased shares worth Rs 4,148.48 crore, according to exchange data.
Gold Prices
Gold prices rose by Rs 700 on Friday to Rs 1,30,160 per 10 grams in Delhi on the back of positive global cues and strong investor demand. Gold with 99.5 per cent purity also climbed Rs 700 to Rs 1,29,560 per 10 grams. Meanwhile, spot gold gained 1 per cent to a two-week high globally on expectations of a US rate cut next month, boosting demand for the non-yielding metal. Silver also surged to a fresh all-time high.
Nifty Outlook for Monday, December 1
According to Pravesh Gour, Senior Technical Analyst at Swastika Investmart, Nifty is in a consolidation phase after hitting fresh record highs, suggesting profit booking at elevated levels. The index remains above short-term moving averages, keeping the broader bias positive. The 26,142–26,310 zone is crucial — a breakout could drive the index toward 26,405 and 26,570, while a slip below 26,150 may result in a corrective move toward 26,025 and 25,850.
Ravi Singh, Chief Research Officer at Master Capital Services, said Nifty continues to trade comfortably above its 21-day and 55-day EMAs, reinforcing a strong bullish setup. The MACD remains positive, suggesting continued momentum. He recommends a buy-on-dips strategy, with fresh longs around 26,050–26,000 and a stop-loss at 25,750. On the upside, Nifty could move toward the 26,500 level in the near term.
Bank Nifty Outlook
Bank Nifty scaled a fresh all-time high of 59,866 and extended its winning streak for the fifth straight week. The index continues to outperform, backed by strong participation from major banking stocks. A decisive move above 60,000 could push the index toward 60,300–60,400, while 59,400 and 59,000 are seen as key support levels on pullbacks.
Disclaimer: The views and investment tips by experts in this News18.com report are their own and not those of the website or its management. Users are advised to check with certified experts before taking any investment decisions.
Aparna Deb is a Subeditor and writes for the business vertical of News18.com. She has a nose for news that matters. She is inquisitive and curious about things. Among other things, financial markets, economy, a…Read More
Aparna Deb is a Subeditor and writes for the business vertical of News18.com. She has a nose for news that matters. She is inquisitive and curious about things. Among other things, financial markets, economy, a… Read More
November 30, 2025, 12:32 IST
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Business
FDA official calls UniQure’s gene therapy a ‘failed’ treatment for Huntington’s disease
Thomas Fuller | SOPA Images | Lightrocket | Getty Images
UniQure needs to run another study to prove that its gene therapy “actually helps people with Huntington’s disease,” a senior U.S. Food and Drug Administration official said on a call with reporters Thursday.
The official, who requested anonymity before discussing sensitive information, confirmed the agency has asked the company to run a placebo controlled trial of its treatment, which is administered directly into the brain. UniQure has said that type of study isn’t ethical because it would require putting people under general anesthesia for hours, a characterization the official disputed.
“So what is really going on? UniQure is the latest company to make a failed therapy for Huntington’s patients,” the official said. “They likely acknowledge or understand at some deep level that their trial failed years ago, and instead of doing the right thing and running the correct clinical study, UniQure is performing a distorted or manipulated comparison in the mind of FDA.”
The comments mark the latest development in a messy public spat between UniQure and the FDA, and as the agency comes under fire for a number of recent drug approval application rejections, including some where companies have accused it of going back on previous guidance. FDA Commissioner Marty Makary in an interview with CNBC’s Becky Quick last week seemingly criticized UniQure’s gene therapy for Huntington’s disease. Makary didn’t name UniQure but described its treatment.
UniQure then accused the FDA of reversing its stance that the company’s clinical trial data would be sufficient to seek approval. UniQure’s study used an outside database to measure how patients with Huntington’s disease might decline without treatment, known as an external control. UniQure has said it wouldn’t be feasible to run a true randomized, double-blind placebo-controlled study, considered the gold standard, because it wouldn’t be ethical to make people undergo a sham hours-long brain surgery.
The FDA official said the agency “never agreed to accept this distorted comparison” and the FDA “never makes such assurances.” Instead, the “FDA will always say, ‘Well, we have to see the data when we get it.'”
UniQure didn’t immediately comment.
The company’s stock rose more than 10% on Thursday and has fallen 58% this year as of Thursday afternoon.
Business
US mortgage rates rise to 6% after three-week slide as oil-driven bond yields climb – The Times of India
The average long-term US mortgage rate edged higher this week, ending a three-week decline as bond yields rose amid oil-price pressures linked to the war with Iran.The benchmark 30-year fixed mortgage rate increased to 6% from 5.98% last week, mortgage buyer Freddie Mac said on Thursday. A year ago, the average rate stood at 6.63%, AP reported.The modest uptick breaks a three-week slide in borrowing costs, with mortgage rates having hovered close to the 6% mark for most of this year. Last week’s average had marked the first time the rate dipped below 6% since September 2022, reaching its lowest level in nearly three and a half years.Mortgage rates are influenced by several factors, including the Federal Reserve’s interest-rate policy, investor expectations about inflation and economic growth, and movements in the bond market.They typically track the direction of the 10-year US Treasury yield, which lenders use as a benchmark for pricing home loans.The 10-year Treasury yield rose to 4.14% at midday Thursday, up from around 4% a week earlier.Treasury yields have moved higher in recent days as rising oil prices added fresh inflation concerns, potentially complicating the Federal Reserve’s plans to cut interest rates.
Business
US stocks today: Dow tumbles 800 points, S&P 500 and Nasdaq slip as oil surges after Iran tanker strike – The Times of India
US stock markets fell on Thursday as investors turned cautious after the previous session’s rally, while rising oil prices and geopolitical tensions weighed on sentiment.The Dow Jones Industrial Average dropped 801 points, or 1.6 per cent, dragged down by losses in stocks such as Caterpillar and Goldman Sachs. The S&P 500 declined 0.9 per cent, while the Nasdaq Composite fell 0.6 per cent.The selloff came as crude oil prices jumped to their highest level since June 2025 after Iran said it had struck an oil tanker with a missile. US West Texas Intermediate crude futures surged 6 per cent to trade above $79 per barrel, while international benchmark Brent crude futures rose about 3 per cent to more than $84 per barrel. Oil prices had stabilised in the previous trading session.Markets had rallied on Wednesday, supported by gains in technology and semiconductor stocks. The Dow had snapped a three-day losing streak, while the S&P 500 and Nasdaq Composite ended the session with solid gains.Despite the ongoing US-Israeli air campaign against Iran, US markets have performed relatively better than European and Asian counterparts this week, largely supported by a rebound in technology stocks that had been hit hard during February’s selloff.The tech-led recovery in the previous session helped the Nasdaq erase its weekly losses, putting the index on track to end the week in positive territory if gains hold through Friday.Investors remain concerned that prolonged disruption to shipping through the Strait of Hormuz — a key global energy corridor –could push oil prices higher and add to inflationary pressures through rising energy and shipping costs.Markets are particularly wary of crude prices moving towards $100 per barrel, which could complicate the Federal Reserve’s efforts to control inflation while considering interest-rate cuts.“For the past couple of years, bringing inflation down has been the Fed’s entire focus, and they were finally making progress. But if energy stays expensive, inflation could start climbing again and that would force the Fed to rethink its plans,” said Adam Sarhan, chief executive of 50 Park Investments, Reuters quoted.According to data compiled by LSEG, investors are increasingly expecting the Federal Reserve to delay a 25-basis-point interest rate cut to September from the previously anticipated July timeline.Among sectors, healthcare led declines on the S&P 500, dropping 1.6 per cent. The energy index, however, gained 0.7 per cent, with shares of ConocoPhillips and Valero Energy rising about 2 per cent each.The CBOE volatility index (VIX), widely seen as a gauge of market fear, rose 0.9 points to 22.08, reflecting cautious investor sentiment. The small-cap Russell 2000 index fell 1 per cent.Travel and tourism stocks, which are sensitive to fuel costs, were under pressure. Delta Air Lines slipped 3.3 per cent, while Royal Caribbean Cruises declined 0.6 per cent.On the other hand, some travel booking companies rallied sharply. Booking Holdings jumped 11 per cent and Expedia surged 8 per cent after a report by The Information said OpenAI was scaling back on-platform shopping checkout plans for ChatGPT, easing concerns about disruption to online marketplace businesses.Chip stocks showed mixed performance. Nvidia edged down 0.3 per cent, while Marvell Technology gained 1.3 per cent.Shares of Broadcom rose 2.9 per cent after the chip designer projected that its artificial intelligence chip revenue could exceed $100 billion next year.Elsewhere, Trade Desk surged 22.5 per cent following a report that OpenAI had held early discussions with the advertising technology company regarding the sale of advertisements.Economic data released on Thursday showed the number of Americans filing new applications for unemployment benefits remained unchanged last week.Investors are also awaiting remarks from Federal Reserve Vice Chair Michelle Bowman later in the day, ahead of the closely watched non-farm payrolls report due on Friday.On the New York Stock Exchange, declining stocks outnumbered advancers by a ratio of 2.48-to-1, while on the Nasdaq the ratio stood at 1.63-to-1.The S&P 500 recorded four new 52-week highs and two new lows, while the Nasdaq Composite registered 17 new highs and 33 new lows.
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