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PSX closes lower amid contract rollover pressure | The Express Tribune

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PSX closes lower amid contract rollover pressure | The Express Tribune



KARACHI:

The Pakistan Stock Exchange (PSX) closed lower on Tuesday amid ongoing contract rollover pressure on investors. The KSE-100 index remained volatile, hitting intra-day high of 149,453 points, before coming significantly down to close at 148,435, a decrease of 380.24 points, or 0.26%.

Analysts mentioned that concerns over a proposed hike in industrial gas tariffs, alongside geopolitical uncertainty, played a key role in bearish activity at the bourse.

Read: PSX opens rollover week on turbulent note

Ahsan Mehanti of Arif Habib Corp commented that stocks closed lower, pressured by futures contract rollovers, sluggish global equities and falling international crude oil prices. A steady policy rate, concerns over a proposed hike in industrial gas tariffs and geopolitical uncertainty fueled the negative close at the PSX, he said.

In its market review, Topline Securities remarked that the KSE-100 index ended the trading session at 148,435, posting a decline of 380 points. The session was marked by notable intra-day volatility, with the index hitting the day’s high at 149,453, reflecting the ongoing rollover pressure.

Gains in Fauji Fertiliser, Hub Power and Pakistan Oilfields collectively contributed 295 points to the index. However, those gains were offset by losses in Engro Holdings, Bank AL Habib, Meezan Bank, MCB Bank and Habib Bank, which together pulled the KSE-100 down by 549 points, Topline noted.

Overall trading volumes decreased to 665.4 million shares compared with Monday’s tally of 693.3 million. Traded value rose to Rs31.5 billion compared to Rs26.3 billion in the previous session.

Read More: KSE-100 races to 150,000 — too fast, too soon?

Shares of 479 companies were traded. Of these, 196 stocks closed higher, 256 dropped and 27 remained unchanged. First Dawood Properties was the volume leader with trading in 40.2 million shares, falling one rupee to close at Rs7.43.



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Anthropic officially designated a supply chain risk by Pentagon

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Anthropic officially designated a supply chain risk by Pentagon



The supply chain risk designation of the artificial intelligence firm is a first for a US company.



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FDA official calls UniQure’s gene therapy a ‘failed’ treatment for Huntington’s disease

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FDA official calls UniQure’s gene therapy a ‘failed’ treatment for Huntington’s disease


Thomas Fuller | SOPA Images | Lightrocket | Getty Images

UniQure needs to run another study to prove that its gene therapy “actually helps people with Huntington’s disease,” a senior U.S. Food and Drug Administration official said on a call with reporters Thursday.

The official, who requested anonymity before discussing sensitive information, confirmed the agency has asked the company to run a placebo controlled trial of its treatment, which is administered directly into the brain. UniQure has said that type of study isn’t ethical because it would require putting people under general anesthesia for hours, a characterization the official disputed.

“So what is really going on? UniQure is the latest company to make a failed therapy for Huntington’s patients,” the official said. “They likely acknowledge or understand at some deep level that their trial failed years ago, and instead of doing the right thing and running the correct clinical study, UniQure is performing a distorted or manipulated comparison in the mind of FDA.”

The comments mark the latest development in a messy public spat between UniQure and the FDA, and as the agency comes under fire for a number of recent drug approval application rejections, including some where companies have accused it of going back on previous guidance. FDA Commissioner Marty Makary in an interview with CNBC’s Becky Quick last week seemingly criticized UniQure’s gene therapy for Huntington’s disease. Makary didn’t name UniQure but described its treatment.

UniQure then accused the FDA of reversing its stance that the company’s clinical trial data would be sufficient to seek approval. UniQure’s study used an outside database to measure how patients with Huntington’s disease might decline without treatment, known as an external control. UniQure has said it wouldn’t be feasible to run a true randomized, double-blind placebo-controlled study, considered the gold standard, because it wouldn’t be ethical to make people undergo a sham hours-long brain surgery.

The FDA official said the agency “never agreed to accept this distorted comparison” and the FDA “never makes such assurances.” Instead, the “FDA will always say, ‘Well, we have to see the data when we get it.'”

UniQure didn’t immediately comment.

The company’s stock rose more than 10% on Thursday and has fallen 58% this year as of Thursday afternoon.



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Ogra warns of strict action against illegal hoarding of petroleum products – SUCH TV

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Ogra warns of strict action against illegal hoarding of petroleum products – SUCH TV



The Oil and Gas Regulatory Authority (Ogra) on Thursday warned of strict action against any individual or entity found involved in the illegal hoarding of petroleum products at unauthorised locations, particularly at places other than duly licensed oil depots and retail outlets of Oil Marketing Companies (OMCs).

In a statement, an Ogra spokesperson said: “Any premises found involved in the illegal storage of petroleum products will be sealed.”

The spokesperson assured the public that the country currently holds sufficient stocks of petroleum products to meet national demand and that there is no need for panic buying or hoarding.

In view of the prevailing geopolitical situation, the official said that the authorities are closely monitoring the petroleum supply chain to ensure the uninterrupted availability of products across the country.

“The existing stock position remains comfortable and well within the prescribed requirements,” read the statement.

Reports have indicated that certain elements may attempt to hoard petroleum products for profiteering under such circumstances, the spokesperson said, adding: “To curb such practices, all provincial chief secretaries have been requested to direct deputy commissioners (DCs) to conduct inspections within their respective jurisdictions.”

Meanwhile, teams of Ogra are actively monitoring the situation in the field, the official added.

Inspections are being carried out at oil depots and retail outlets to ensure the smooth supply of petroleum products and to prevent any malpractice, read the statement.

Ogra advised the public not to pay attention to rumours and to maintain normal consumption patterns, as the petroleum supply situation in the country remains stable.

Uninterrupted petroleum supply top priority: FinMin

Separately, Finance Minister Muhammad Aurangzeb has said that ensuring uninterrupted availability of petroleum products across the country is the government’s top priority.

The finance czar made the remarks while chairing a meeting of the committee to Monitor Petrol Prices in the Wake of the Emerging Situation in the region, constituted by Prime Minister Shehbaz Sharif, in Islamabad today.

The committee was briefed that national reserves remain at comfortable levels, with sufficient cover available for key products, and that there is no immediate cause for concern regarding the availability of petroleum products.

It reviewed multiple supply and pricing scenarios to ensure preparedness under different contingencies and to maintain stability in domestic energy supplies.

The committee will finalise its recommendations by tomorrow for onward submission to the prime minister.

It will continue to meet on a daily basis to monitor developments, review stock positions and supply chain movements, and ensure timely execution across all stakeholders.

The committee also noted that “war premium” dynamics and intensified competition for energy cargoes, particularly in Asian markets, could raise external account pressures if volatility persists.

The body reviewed ongoing efforts to strengthen supply assurance through diversified sourcing and logistics arrangements.

The committee also considered shipping and operational measures to reduce time lags, including facilitation of timely berthing and the use of available national shipping capacity where feasible.

To safeguard orderly market conditions, the committee discussed measures to deter hoarding, illegal storage, and diversion, including coordinated enforcement actions by provincial administrations in close collaboration with the Ogra and relevant agencies.

The committee emphasised that preventing outward smuggling and ensuring uninterrupted domestic distribution will remain a top operational priority, and that real-time field intelligence and strict action against violations will be maintained.



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