The latest brain-computer interface could help people recover from severe depression. Motif Neurotech announced Monday that the US Food and Drug Administration has approved a human study to trial the company’s blueberry-sized brain implant that sits in the skull and delivers electrical stimulation to treat depression.

The Houston-based startup, founded in 2022, is part of a budding industry pursuing technology to read and interpret brain signals. While other companies exploring similar technology, like Elon Musk’s Neuralink, Paradromics, and Synchron, are developing devices to enable paralyzed people to communicate and use computers, Motif is aiming to ease depression in people who have not benefited from medication.

The company’s device is implanted in the skull just above the dura, the brain’s protective membrane. It targets the central executive network, a part of the brain that is responsible for high-level cognitive functions and is underactive in major depressive disorder. The implant emits specific patterns of stimulation to turn “on” this network.

Motif’s device would allow patients to receive therapeutic brain stimulation at home. “Through frequent electrical stimulation, we think we can drive that neuroplasticity that creates stronger connectivity within the central executive network for patients with depression, so that they can get out of bed in the morning, call their friends, go to the gym,” says Jacob Robinson, Motif’s cofounder and CEO.

Electrical stimulation has been used for decades to treat depression, and Motif’s approach is just the latest iteration. Electroconvulsive or “shock” therapy began in the 1930s and is still used today in cases where patients don’t benefit from antidepressants. Deep brain stimulation, which involves surgically implanting electrodes into the brain, is occasionally used experimentally but is not FDA approved. A much milder form of stimulation known as transcranial magnetic stimulation, or TMS, was approved in 2008. While it can be highly effective, it typically requires a lengthy treatment regimen of five treatments a week for six weeks.

A study from 2021 found that during a 12-month period in the United States, nearly 9 million adults were undergoing treatment for major depressive disorder, and of those, almost 3 million were considered to have treatment-resistant depression, when symptoms do not improve after at least two, and often more, antidepressant medications.

Motif’s device can be implanted in a 20-minute outpatient procedure without the need for brain surgery. It’s powered by wireless magnetoelectric technology that Robinson developed while at Rice University and is charged with a baseball cap that patients will wear when receiving the stimulation.

David Silver gave the world its very first glimpse of superintelligence.

In 2016, an AI program he developed at Google DeepMind, AlphaGo, taught itself to play the famously difficult game of Go with a kind of mastery that went far beyond mimicry.

Silver has since founded his own company, Ineffable Intelligence, that aims to build more general forms of AI superintelligence. The company will do this, Silver says, by focusing on reinforcement learning, which involves AI models learning new capabilities through trial and error. The vision is to create “superlearners” that go beyond human intelligence in many domains.

This approach stands in contrast to how most AI companies plan to build superintelligence, by exploiting the coding and research capabilities of large-language models.

Silver, speaking to WIRED from his office in London, says he thinks this approach will fail. As amazing as LLMs are, they learn from human intelligence—rather than building their own.

“Human data is like a kind of fossil fuel that has provided an amazing shortcut,” Silver says. “You can think of systems that learn for themselves as a renewable fuel—something that can just learn and learn and learn forever, without limit,” he says.

I’ve met Silver a few times and—despite this proclamation—he’s always struck me as one of the more humble people in AI. Sometimes, when talking about ideas he considers silly, he flashes a puckish grin. Right now, though, he’s deadly serious.

“I think of our mission as making first contact with superintelligence,” he says. “By superintelligence I really mean something incredible. It should discover new forms of science or technology or government or economics for itself.”

Five years ago, such a mission might have seemed ridiculous. But tech CEOs now routinely talk about machines outpacing human intelligence and replacing entire categories of workers. The idea that some new technical twist might unlock superhuman AI capabilities has recently spawned a raft of billion-dollar startups.

Ineffable Intelligence has so far raised $1.1 billion in seed funding at a valuation of $5.1 billion—an enormous sum by European AI standards. Silver has also recruited top AI researchers from Google DeepMind and other frontier labs to join his endeavor.

Silver says he will give all of the money he makes from equity in Effable Intelligence—a sum that could amount to billions if he is successful—away to charity.

“It’s a huge responsibility to build a company focusing on superintelligence,” he tells me. “I think this is something that has to be done for the benefit of humanity, and any money that I make from Ineffable will will go to high-impact charities that save as many lives as possible.”

Total Focus

Silver met Demis Hassabis, the CEO of Google DeepMind, at a chess tournament when they were kids, and the pair later became lifelong friends and collaborators.

They remained close after Silver left Google DeepMind, which he did only because he wanted to chart a completely new path. “I feel it’s really important that there is an elite AI lab that actually focuses a hundred percent on this approach,” he says. “That it’s not just a corner of another place dedicated to LLMs.”

The limits of the LLM-based approach can be seen, Silver says, with a simple thought experiment. Imagine going back in time and releasing a large language model in a world that believed the world was flat. Without being able to interact with the real world, the system, he says, would remain an avid flat-earther, even if it continued to improve its own code.

An AI system that can learn about the world for itself, however, could make its own scientific discoveries.

If you ask any technology leader, they will tell you that cybersecurity has become a higher priority than ever, with sophisticated cyberattacks causing high-profile incidents around the world. According to data from the World Economic Forum, the global cost of cybercrime is forecast to reach USD $12.2 trillion by 2031, placing the scale of cybercriminal operations on a par with some of the world’s largest economies.

But are tech leaders risking a cyber resourcing crisis by not sufficiently rewarding their security teams?