Tech
Trump’s Tylenol Directive Could Actually Increase Autism Rates, Researchers Warn
For decades, the discussion around autism has been a hotbed of misinformation, misinterpretation, and bad science, ranging from the long-discredited link between the neurodevelopmental condition and vaccines, to newer claims that going gluten-free and avoiding ultra-processed foods can reverse autistic traits.
On Monday night, this specter arose again in the Oval Office, as President Donald Trump announced his administration’s new push to study the causes of autism with claims that the common painkiller Tylenol, otherwise known as acetaminophen, can cause the condition. The FDA subsequently announced that the drug would be slapped with a warning label citing a “possible association.”
David Amaral, professor and director of research at the UC Davis MIND Institute, was among those watching in dismay as the president launched into a diatribe about Tylenol, repeatedly warning pregnant women not to take it, even to treat fevers.
“We heard the president say that women should tough it out,” says Amaral. “I was really taken aback by that, because we do know that prolonged fever, in particular, is a risk factor for autism. So I worry that this admonition to not take Tylenol is going to do the reverse of what they’re hoping.”
The speculation surrounding Tylenol stems from correlations drawn by some studies that have touted an association between use of the painkiller and neurodevelopmental disorders. One such analysis was published last month. The problem, says Renee Gardner, an epidemiologist at the Karolinska Institute in Sweden, is that these studies often reach this conclusion because they don’t sufficiently account for what statisticians describe as “confounding factors”—additional variables related to those being studied that might influence the relationship between them.
In particular, Gardner points out that pregnant women needing to take Tylenol are more likely to have pain, fevers, and prenatal infections, which are themselves risk factors for autism. More importantly, given the heritability of autism, many of the genetic variants that make women more likely to have impaired immunity and greater pain perception, and hence use painkillers like acetaminophen, are also linked to autism. The painkiller use, she says, is a red herring.
Last year, Gardner and other scientists published what is widely regarded within the scientific field as the most conclusive investigation so far on the subject, one which did account for confounding factors. Using health records from nearly 2.5 million children in Sweden, they reached the opposite conclusion to the president: Tylenol has no link to autism. Another major study of more than 200,000 children in Japan, published earlier this month, also found no link.
Doctors are worried that Trump’s claims will have adverse consequences. Michael Absoud, a paediatric neurodisability consultant and a researcher in pediatric neurosciences at King’s College London, says he fears that pregnant women will start using other painkillers with a less well-proven safety profile.
Gardner is concerned that it will also lead to self-blaming among parents, a flashback to the 1950s and 60s, a time when autism was wrongly attributed to emotionally cold “refrigerator mothers.” “It’s making parents of children with neurodevelopmental conditions feel responsible,” she says. “It harks back to the early dark days of psychiatry.”
Tech
Could You Use a Rowboat to Walk on the Seafloor Like Jack Sparrow?
But you already know about this, because Fg is what normies call an object’s “weight,” and for a given volume, weight depends only on the density. Now, if you dropped these blocks in a lake, obviously the styrofoam would float and the steel would sink. So clearly it has something to do with density.
What if you had a block of water with the same volume? If you could somehow hold this cube of water, it would feel pretty heavy, about 62.4 pounds. Now, if you place it carefully in a lake, will it sink or bob on the surface like styrofoam? Neither, right? It’s just going to sit there.
Since it doesn’t move up or down, the total force on the block of water must be zero. That means there has to be a force counteracting gravity by pushing up with equal strength. We call this buoyancy, and for any object, the buoyancy force is equal to the weight of the water it displaces.
So let’s think about this. The steel block displaces the same amount of water, so it has the same upward-pushing buoyancy force as the block of water. But because it’s denser and has more mass, down it goes.
In general, an object will sink if the gravitational force exceeds the buoyancy force, and it will float if the buoyancy force exceeds the gravitational force. Another way of saying that is, an object will sink if it’s denser than water and it will float if it’s less dense.
And right in the middle an object will neither sink nor rise to the surface—we call that neutral buoyancy. Humans are pretty close to neutral because our bodies are 60 percent water. That’s why you feel weightless underwater—the buoyancy force pretty much offsets the gravitational force.
Avast! Hold on there, matey. Aircraft carriers are made of steel and weigh 100,000 tons, so why do they float? Can you guess? It’s because of their shape. Unlike a block of steel, a ship’s hull is hollow and filled with air, so it has a large volume relative to its weight.
But what if you start filling it with cargo? The ship gets heavier, which means it must displace more water to reach that equilibrium point. In general, when you launch a boat or ship into the water, it’ll sink down until the weight of the water it pushes aside equals the boat’s total weight.
Tech
Sleep Number’s P6 Smart Bed Takes Customization to a New Level
Screenshots: Julia Forbes
I spoke with Raj Mills, Sleep Number’s senior vice President of partnerships and research. She tells me, “Our AI models take into account foam depth and still maintain the same level of accuracy regardless of how far below the surface of the bed the sensors are.” She shares that they are cohesively performing a ballistocardiograph, which monitors the blood flow generated by the heart and ultimately determines your heart rate score. How effectively they can do so is debatable.
Ultimately, I found there was quite a bit of variance in terms of the nightly score calculated on both ends. On good nights, both pointed to higher scores, but the final number could differ by up to 10 points. On the Sleep Number app, I found it concerning that most of the time, my Sleep Score numbers were not as high as I thought they would be—my average for the three-week test period was a 74.
Matrix Mattress
If you prefer a remote, that’s either a separate cost ($50) or potentially a different bed altogether. The only way to operate this mattress is by creating an account and downloading the app in advance. Security of one’s personal data is top of mind for many, and I wanted to know how the vast quantities of data accumulated by Sleep Number’s customer base were managed. When you first sign up for your account, you can either share your data with Sleep Number or opt out altogether. For those who share their data willingly—about 550,000 individuals, according to Mills—Sleep Number’s data science team performs research and presents findings from its consumer base at major sleep conferences, including SLEEP and World Sleep Congress.
It’s a comprehensive data set to work with, and it continues to evolve through the adaptive AI at play, which includes SleepIQ technology. According to Mills, the company’s AI models are structured to analyze sleepers at an individual level, because every sleeper has a different build, age, pain issues, and various needs. According to Sleep Number’s privacy policy, the company doesn’t sell your information to third parties, and you can withdraw your consent to share information at any time. At the end of the day, Sleep Number is a business that can potentially use your data to develop new products, and it’s up to you whether that’s worth it or not.
Power Couple
An adjustable base is what enables each side of the mattress to independently adjust head and foot angles. I tested the FlexFit 3 adjustable base alongside the P6 mattress, which is Sleep Number’s top-of-the-line offering. It offers timed foot warming (which takes about two minutes to heat up and has a two-hour default setting) to help blood flow away from your core and aid faster sleep. There is also a zero-gravity setting, partner snore (elevates the head and neck slightly to help open up airways), and motion-detect underbed lighting. I loved the gentle light source for late-night bathroom breaks, and the split king adjustability allowed me to partake in late-night reading without disturbing my partner. However, the only feature that separates the FlexFit 2 base from the FlexFit 3 is the inclusion of foot warming, and it’s a $400 upcharge for a queen size.
Photograph: Julia Forbes
Tech
HP’s ZBook 8 Gli Is a Workstation That Doesn’t Impress
The concept behind the portable workstation isn’t a new or particularly challenging one. Load up a laptop with top-tier specs to make it as powerful and future-proof as possible, and never mind if it adds a few ounces and inches to the load. Ostensibly, these machines are designed with heavy grind tasks in mind, such as video editing or CAD work. Money has historically been no object with the mobile workstation. If you needed this kind of juice, it was expected that you (or, more likely, your employer) would have to pay for it.
HP’s new ZBook 8 G1i checks off all those boxes, though it arrived with a curious twist: A deep discount of more than $2,500 off an over-$4,000 asking price, dramatically bringing the price of the machine down to something in line with a traditional laptop. I’m listening.
Photograph: Chris Null
Thick as a Brick
If it weren’t for the extra girth (27 mm) and weight (3.8 pounds), this laptop would easily pass for any old 14-inch system. (It’s also available in a 16-inch version.) It’s anonymous otherwise, and little thought has been given to industrial design here. Standard HP branding is affixed to a metallic gray chassis composed of partially recycled aluminum and plastic. Gently rounded corners do little to conceal the surprisingly wide bezels around the display, and the keyboard and trackpad are perfectly functional if utilitarian in appearance. If you’d been handed this machine on your first day of work in 2014, you’d probably be pretty jazzed.
Mobile workstations are all about the specs, and to that end, the ZBook 8 is rather surprising. While the inclusion of 64 GB of RAM is on point, the choice of CPU—an Intel Core Ultra 7 265H—is odd, landing just about in the middle of the Core Ultra Series 2 power spectrum. At the very least, it seems like an Ultra 9 would be in order. A 1-terabyte SSD was included in my test configuration. The screen size of 2560 x 1600 pixels is fine for a 14-inch (non-touchscreen) device, but shy of anything I’d consider dazzling.
Discrete graphics—common for a workstation—are present, but the system includes an Nvidia GeForce RTX 500 Ada Generation GPU, a niche processor I’ve never actually encountered in the wild. Nearly two years old, the 500 Ada is a stripped-down version of the GeForce RTX 4060. Benchmarks peg its performance as roughly on par with the mobile GeForce GTX 1000 series. Again, it’s a curious choice for the machine.
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