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Viking Therapeutics shares fall 40% on disappointing obesity pill trial data

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Viking Therapeutics shares fall 40% on disappointing obesity pill trial data


Shares of Viking Therapeutics plunged Tuesday after the company released midstage trial data on its obesity pill that disappointed investors. 

The biotech company’s stock price dropped to about $23.80 as of Tuesday morning, from $42.09 at Monday’s close, a roughly 43% plunge. Viking’s market cap now sits at about $2.69 billion, down from more than $4 billion on Monday.

The results could be a blow to Viking, which was once seen as a hot M&A target as pharmaceutical companies scramble to join the booming market for obesity and diabetes drugs. It could reinforce the dominance of Eli Lilly and Novo Nordisk in the space, especially as they develop pills for weight loss that could enter the market years ahead of the tablet formulation of Viking’s drug, VK2735. 

Jared Holz, Mizuho health care equity strategist, said in an email Tuesday that the data “probably shutters hope for [Viking] to be a bigtime player in the oral obesity market over the near to medium term.”

The race to develop a more convenient obesity pill has been fraught, as companies such as Pfizer have had to scrap previous contenders and bring forward new ones. 

Viking’s once-daily pill helped patients lose up to 12.2% of their weight at around three months. The company also said that weight loss didn’t plateau, which means patients could lose even more in a longer-term study.

It’s difficult to directly compare the pill’s phase two trial data with the results of oral drugs further along in development, including treatments developed by Eli Lilly and Novo Nordisk.

Holz added that the results on Viking’s pill “look inferior” to those of Eli Lilly’s oral drug “on almost all metrics.” The highest dose of Eli Lilly’s daily pill helped patients lose 12.4% of their body weight, or 11.2% regardless of discontinuations, at 72 weeks in a phase three trial.

Holz pointed to the high rate of patients who discontinued Viking’s drug for any reason over 13 weeks, which was around 28%. Meanwhile, around a quarter of people discontinued Eli Lilly’s pill, orforglipron, for any reason over 72 weeks.

That’s “a much longer trial and therefore [Lilly] looks far better head-to-head,” Holz said. 

Viking said the most common reasons for patients to discontinue treatment were gastrointestinal side effects, the majority of which were mild to moderate in severity and observed earlier in treatment.  But around 58% of patients reported experiencing nausea and 26% experienced vomiting, compared with 48% and 10%, respectively, among those who took a placebo.

Those side effect rates over a shorter trial period appear to be worse than those seen in trials on Eli Lilly’s pill and the oral version of Novo Nordisk’s weight loss drug Wegovy. 

Viking’s treatment works by imitating two naturally produced gut hormones called GLP-1 and GIP.

GLP-1 helps reduce food intake and appetite. GIP, which also suppresses appetite, may also improve how the body breaks down sugar and fat.

Eli Lilly’s pill and the oral version of Novo Nordisk’s Wegovy both target GLP-1, but the latter has dietary restrictions.



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EY and Microsoft launch AI skills passport: Free program to train youth in AI; focus on career growth – The Times of India

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EY and Microsoft launch AI skills passport: Free program to train youth in AI; focus on career growth – The Times of India


EY and Microsoft on Saturday launched the AI Skills Passport, a free online learning initiative aimed at equipping Indian students and early-career professionals with essential artificial intelligence (AI) skills. The program targets individuals aged 16 and above and is designed to bridge the country’s growing AI skills gap, according to an EY statement, ANI reported.Part of a global effort that has already engaged over 40,000 participants worldwide, the AI Skills Passport offers self-paced learning modules spanning around 10 hours, available in both English and Hindi. The curriculum covers AI fundamentals, responsible AI, and practical applications across sectors including healthcare, finance, and technology. Participants also receive guidance on job readiness, including resume tips, interview support, and networking insights.Learners who complete the program are awarded a verifiable digital badge, enhancing their professional profiles. The initiative is part of EY Ripples, EY’s global corporate responsibility programme, and will partner with not-for-profit organisations to ensure students from economically weaker backgrounds have access to mentorship, learning, and career guidance.Monesh Dange, Partner and Leader, Alliances and Ecosystems, EY India, said, “In an era where AI is revolutionising work, the AI Skills Passport addresses India’s urgent need for skilled talent. Together with Microsoft, we aim to ensure the program is accessible and impactful at scale.”Bhaskar Basu, Enterprise Partnerships Leader, Microsoft India & South Asia, added, “AI is transforming India’s digital economy, and youth are at its core. The AI Skills Passport brings high-quality AI learning to everyone, accelerating Microsoft’s goal to equip 10 million Indians with AI skills by 2030.”





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Environment minister Bhupender Yadav heads to Brazil: India engages in pre-talks ahead of COP30; climate finance and adaptation on agenda – The Times of India

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Environment minister Bhupender Yadav heads to Brazil: India engages in pre-talks ahead of COP30; climate finance and adaptation on agenda – The Times of India


Union Environment Minister Bhupender Yadav is set to travel to Brasília on October 13-14 for a pre-COP meeting as India steps up preparations for the UN climate summit COP30, scheduled in Belém, Brazil, in November. The meeting aims to streamline negotiations on key issues and build consensus among ministers before the main conference. He confirmed his visit on his X account. The two-day pre-COP will bring together environment and climate ministers, senior negotiators, and observers to narrow differences on politically sensitive issues and build ministerial consensus ahead of the COP30 negotiations, PTI reported. The COP30 presidency expects 30-50 delegations and around 800 participants at the event.Pre-COPs, while not formal UNFCCC events, have become a routine instrument for host countries to focus ministerial attention on a limited set of political questions that otherwise take negotiators weeks to resolve. Ministers use these meetings to test negotiating texts, identify common ground, and prepare positions to expedite negotiations at the main COP.COP30 is unfolding against a complex geopolitical backdrop, with some developed countries reassessing climate strategies amid economic and energy security pressures. The United States’ withdrawal from the Paris Agreement has further heightened tensions. Disagreements over climate finance, the pace and responsibility of the energy transition, and burdens on developing countries remain sharp.Trust between developed and developing countries is fragile following COP29 in Baku, Azerbaijan, where many Global South delegates said finance outcomes fell short of expectations. Central issues include the scale and nature of climate finance, grant versus loan structures, and predictability of funds for adaptation and loss and damage. These topics are expected to dominate discussions in Brasília and later in Belém.Logistical concerns are adding further pressure. Reports indicate shortages of hotel rooms and high costs in Belém, potentially limiting participation of smaller delegations and vulnerable countries. Observers warn that unequal attendance could affect negotiating dynamics and the legitimacy of outcomes.Key discussion points include climate finance, the post-2025 collective finance goal, rules and integrity for international carbon trading under Article 6, adaptation and national adaptation plans, and translating the Global Stocktake into actionable timelines. Loss and damage finance will also be a priority, with ministers aiming to make it predictable and accessible.India has emphasised equity and differentiated responsibilities in climate action, urging developed countries to meet Article 9 obligations on finance. It has pressed for predictable and concessional support for adaptation and loss and damage, while highlighting the need for technology transfer and capacity building aligned with national circumstances. India has also underscored a just energy transition that allows space for development.Ahead of COP30, India plans to submit two key documents: an updated Nationally Determined Contribution (NDC), extending commitments to 2035, and the country’s first national adaptation plan (NAP). The updated NDC is expected to raise ambition on emissions intensity of GDP, non-fossil electricity capacity, and carbon sinks through forest and tree cover, without introducing new pledges. India has already exceeded its target for non-fossil installed capacity ahead of the 2030 deadline.Officials told PTI that India will closely monitor outcomes on carbon markets and accounting, ensuring that poorly designed rules do not shift burdens or create perverse incentives.





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Foreign Investors Turn Buyers In Indian Markets This Month Amid Positive Cues

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Foreign Investors Turn Buyers In Indian Markets This Month Amid Positive Cues


New Delhi: The intensity of foreign portfolio investor (FPI) selling in the Indian markets slowed down significantly in October, analysts said on Sunday.

The shift in the FPI trading strategy is significant and it stems from two factors.

One, the valuation differentials between India and other markets, which were high earlier, had come down significantly in recent weeks following the rally in other markets and consolidation in the Indian market.

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“Two, the growth and earnings prospects for India have been revised upward by market experts. The GST cuts and the low interest regime are expected to boost India Inc’s earnings in FY27, which the market will soon start discounting,” said Dr VK Vijayakumar, Chief Investment Strategist, Geojit Investments Ltd.

Foreign investors turned buyers in the cash market on the last four trading sessions of the week ended on October 10.

The cash market buy figure during the last four trading sessions stands at Rs 3,289 crore.

The global market sentiment has again turned negative with the reignite of the US-China trade war, following US President Donald Trump’s threat to impose 100 per cent tariff on imports from China and restricting many critical US exports to China.

The FPI flows, going forward, will depend on how this renewed trade war pans out in the coming days, said analysts.

Siddhartha Khemka, Head of Research, Wealth Management, Motilal Oswal Financial Services Ltd, said Nifty50 edged higher by 104 points to close at 25,285 last Friday, amid improving global sentiment, supported by easing geopolitical tensions as Israel and Hamas agreed on the first stage of a ceasefire plan, along with signs of progress in a potential India–US trade deal.

“Renewed FPI buying also boosted sentiment. Additionally, India and the UK announced multiple collaborations across sectors including education, critical minerals, climate change, and defence,” he mentioned.

With the valuation differential coming down and Indian earnings likely to improve in FY27, foreign portfolio investors (FPIs) are likely to slow down selling going forward.

Sustained FPI selling continued in September with the sell figure through exchanges touching Rs 27,163 crore. However, in keeping with the long-term trend of buying through the primary market, they bought equity for Rs 3,278 crore in September.

On the macro front, investors will closely track India’s retail inflation print for September, to be released on Monday.

 



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