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Security flaws in portable genetic sequencers risk leaking private DNA data

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Security flaws in portable genetic sequencers risk leaking private DNA data


Credit: Mikhail Nilov from Pexels

Portable genetic sequencers used around the world to sequence DNA have critical, previously unreported security vulnerabilities that could reveal or alter genetic information without detection, according to a new study.

Researchers from the University of Florida have, for the first time, exposed these security risks in devices from Oxford Nanopore Technologies, which produces nearly all the portable genetic sequencers in the world.

Alerted by the , Oxford Nanopore Technologies has rolled out updated software to patch the vulnerabilities. But out-of-date software, or unsecured internet systems, could still leave some DNA sequencers vulnerable to attack.

“No one in the world had looked at the security of these devices, which shocked me,” said Christina Boucher, Ph.D., a professor of computer and and engineering at UF, expert in bioinformatics, and co-author of the new report.

Boucher collaborated with Sara Rampazzi, Ph.D., also a professor of computer and information science and engineering, cybersecurity expert and project lead at UF, and students in the department to test Nanopore sequencers for . The study serves as a warning to the scientific community that new threats to genomic data urge a shift toward “secure-by-design” systems as portable DNA sequencers become increasingly common. The team published their findings in Nature Communications.

The researchers uncovered three vulnerabilities in the Oxford Nanopore MinION portable sequencer and its associated software. Two of these flaws allow an unauthorized user to improperly access the device and potentially copy or alter the DNA data without the authorized user’s knowledge. A third flaw opens the sequencer to a denial-of-service attack, which would halt the sequencing operation and make the device appear broken.

The Cybersecurity and Infrastructure Security Agency, the federal government’s cyber defense coordinator, verified these vulnerabilities in a report released Oct. 21. The report also provides instructions from Oxford Nanopore Technologies on how users can update their sequencers to address the security flaws.

Versions with older software would remain open to attack. This is especially possible when the portable sequencers are connected to insecure Wi-Fi networks or remote control is activated.

Costing just a few thousand dollars and able to operate anywhere in the world, these palm-sized sequencers have transformed the previously cumbersome and expensive work of sequencing DNA. But that portability contributes to the of these devices because the sequencers must be connected to a computer to work.

“You are connecting a very specialized device to a general-purpose device like a laptop, which is intrinsically assumed to be secure,” said Rampazzi. “Instead, that laptop could be connected to an unsecured network, or it could be infected with malware or ransomware, especially if used in the field outside controlled environments.”

These nanopore sequencers are marketed only for research use and not to be used for clinical diagnosis. Yet even when restricted to research, these devices can be used to sequence the DNA of people.

The U.S. National Institute of Standards and Technology, which focuses on defining genomic cybersecurity and privacy guidelines, has only started to consider research use cases in distinction to clinical use in their latest draft guidelines, highlighting the increased attention on the topic and the lack of a clear standard.

Revealing these previously undiscovered vulnerabilities was only possible due to the interdisciplinary collaboration between the Rampazzi and Boucher labs. Boucher develops algorithms to better analyze DNA, while Rampazzi researches security flaws in ranging from , and self-driving cars to underwater data centers. Combining their expertise helped alert the community to a significant privacy threat.

“In bioinformatics, we haven’t been working as closely with the security community as I think we should be,” Boucher said.

More information:
Toward security-aware portable sequencing, Nature Communications (2025). DOI: 10.1038/s41467-025-66024-z

Citation:
Security flaws in portable genetic sequencers risk leaking private DNA data (2025, November 10)
retrieved 10 November 2025
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The Best Presidents’ Day Deals on Gear We’ve Actually Tested

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The Best Presidents’ Day Deals on Gear We’ve Actually Tested


Presidents’ Day Deals have officially landed, and there’s a lot of stuff to sift through. We cross-referenced our myriad buying guides and reviews to find the products we’d recommend that are actually on sale for a truly good price. We know because we checked! Find highlights below, and keep in mind that most of these deals end on February 17.

Be sure to check out our roundup of the Best Presidents’ Day Mattress Sales for discounts on beds, bedding, bed frames, and other sleep accessories. We have even more deals here for your browsing pleasure.

WIRED Featured Deals

Branch Ergonomic Chair Pro for $449 ($50 off)

  • Photograph: Julian Chokkattu

  • Photograph: Julian Chokkattu

  • Photograph: Julian Chokkattu

Branch

Ergonomic Chair Pro

The Branch Ergonomic Chair Pro is our very favorite office chair, and this price matches the lowest we tend to see outside of major shopping events like Black Friday and Cyber Monday. It’s accessibly priced compared to other chairs, and it checks all the boxes for quality, comfort, and ergonomics. Nearly every element is adjustable, so you can dial in the perfect fit, and the seven-year warranty is solid. There are 14 finishes to choose from.



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Zillow Has Gone Wild—for AI

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Zillow Has Gone Wild—for AI


This will not be a banner year for the real estate app Zillow. “We describe the home market as bouncing along the bottom,” CEO Jeremy Wacksman said in our conversation this week. Last year was dismal for the real estate market, and he expects things to improve only marginally in 2026. (If January’s historic drop in home sales is indicative, that even is overoptimistic.) “The way to think about it is that there were 4.1 million existing homes sold last year—a normal market is 5.5 to 6 million,” Wacksman says. He hastens to add that Zillow itself is doing better than the real estate industry overall. Still, its valuation is a quarter of its high-water mark in 2021. A few hours after we spoke, Wacksman announced that Zillow’s earnings had increased last quarter. Nonetheless, Zillow’s stock price fell nearly 5 percent the next day.

Wacksman does see a bright spot—AI. Like every other company in the world, generative AI presents both an opportunity and a risk to Zillow’s business. Wacksman much prefers to dwell on the upside. “We think AI is actually an ingredient rather than a threat,” he said on the earnings call. “In the last couple years, the LLM revolution has really opened all of our eyes to what’s possible,” he tells me. Zillow is integrating AI into every aspect of its business, from the way it showcases houses to having agents automate its workflow. Wacksman marvels that with Gen AI, you can search for “homes near my kid’s new school, with a fenced-in yard, under $3,000 a month.” On the other hand, his customers might wind up making those same queries on chatbots operated by OpenAI and Google, and Wacksman must figure out how to make their next step a jump to Zillow.

In its 20-year history—Zillow celebrated the anniversary this week—the company has always used AI. Wacksman, who joined in 2009 and became CEO in 2024, notes that machine learning is the engine behind those “Zestimates” that gauge a home’s worth at any given moment. Zestimates became a viral sensation that helped make the app irresistible, and sites like Zillow Gone Wild—which is also a TV show on the HGTV network—have built a business around highlighting the most intriguing or bizarre listings.

More recently, Zillow has spent billions aggressively pursuing new technology. One ongoing effort is upleveling the presentation of homes for sale. A feature called SkyTour uses an AI technology called Gaussian Splatting to turn drone footage into a 3D rendering of the property. (I love typing the words “Gassian Splatting” and can’t believe an indie band hasn’t adopted it yet.) AI also powers a feature inside Zillow’s Showcase component called Virtual Staging, which supplies homes with furniture that doesn’t really exist. There is risky ground here: Once you abandon the authenticity of an actual photo, the question arises whether you’re actually seeing a trustworthy representation of the property. “It’s important that both buyer and seller understand the line between Virtual Staging and the reality of a photo,” says Wacksman. “A virtually staged image has to be clearly watermarked and disclosed.” He says he’s confident that licensed professionals will abide by rules, but as AI becomes dominant, “we have to evolve those rules,” he says.

Right now, Zillow estimates that only a single-digit percentage of its users take advantage of these exotic display features. Particularly disappointing is a foray called Zillow Immerse, which runs on the Apple Vision Pro. Upon rollout in February 2024, Zillow called it “the future of home tours.” Note that it doesn’t claim to be the near-future. “That platform hasn’t yet come to broad consumer prominence,” says Wacksman of Apple’s underperforming innovation. “I do think that VR and AR are going to come.”

Zillow is on more solid ground using AI to make its own workforce more productive. “It’s helping us do our job better,” says Wacksman, who adds that programmers are churning out more code, customer support tasks have been automated, and design teams have shortened timelines for implementing new products. As a result, he says, Zillow has been able to keep its headcount “relatively flat.” (Zillow did cut some jobs recently, but Wacksman says that involved “a handful of folks that were not meeting a performance bar.”)



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Do Waterproof Sneakers Keep the Slosh In or Out? Let WIRED Explain

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Do Waterproof Sneakers Keep the Slosh In or Out? Let WIRED Explain


Running with wet feet, in wet socks, in wet shoes is the perfect recipe for blisters. It’s also a fast track to low morale. Nothing dampens spirits quicker than soaked socks. On ultra runs, I always carry spares. And when faced with wet, or even snowy, mid-winter miles, the lure of weatherproof shoes is strong. Anything that can stem the soggy tide is worth a go, right?

This isn’t as simple an answer as it sounds. In the past, a lot of runners—that includes me—felt waterproof shoes came with too many trade-offs, like thicker, heavier uppers that change the feel of your shoes or a tendency to run hot and sweaty. In general, weatherproof shoes are less comfortable.

But waterproofing technology has evolved, and it might be time for a rethink. Winterized shoes can now be as light as the regular models, breathability is better, and the comfort levels have improved. Brands are also starting to add extra puddle protection to some of the most popular shoes. So it’s time to ask the questions again: Just how much difference does a bit of Gore-Tex really make? Are there still trade-offs for that extra protection? And is it really worth paying the premium?

I spoke to the waterproofing pros, an elite ultra runner who has braved brutal conditions, and some expert running shoe testers. Here’s everything you need to know about waterproof running shoes in 2026. Need more information? Check out our guide to the Best Running Shoes, our guide to weatherproof fabrics, and our guide to the Best Rain Jackets.

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How Do Waterproof Running Shoes Work?

On a basic level, waterproof shoes add extra barriers between your nice dry socks and the wet world outside. If you’re running through puddles deep enough to breach your heel collars, you’re still going to get wet feet. But waterproof shoes can protect against rain, wet grass, snow, and smaller puddles.

Gore-Tex is probably the most common waterproofing tech in footwear, but it’s not the only solution in town. Some brands have proprietary tech, or you might come across alternative systems like eVent and Sympatex. That GTX stamp is definitely the one you’re most likely to encounter, so here’s how GTX works.

The water resistance comes from a layered system that is composed of a durable water repellent (DWR) coating to the uppers with an internal membrane, along with other details like taped seams, more sealed uppers with tighter woven mesh, gusseted tongues, and higher, gaiter-style heel collars.



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