Tech
Weight-Loss Drug Zepbound Is Being Tested as a Treatment for Long Covid
Obesity wonder drugs Wegovy and Zepbound are already showing that they can reduce the risk of cardiovascular and chronic kidney disease in addition to helping people lose weight. Now, a US-wide trial will test whether tirzepatide, the active ingredient in Zepbound, may be an effective treatment for people with long Covid.
Part of a class of drugs known as GLP-1s, tirzepatide acts on receptors in the gut and the brain to regulate appetite. As a result, people shed pounds by eating less. But decreased body weight doesn’t fully explain the positive effects on the heart and kidney. Mounting evidence suggests that the drugs have a broad anti-inflammatory effect on the body—a mechanism that’s of interest for treating long Covid.
As many as 20 million people in the US have experienced long Covid, a chronic condition that lasts for at least three months after an initial infection. While more than 200 symptoms of long Covid have been documented, some of the most common include coughing, shortness of breath, brain fog, fatigue, mood changes, trouble sleeping, and body aches.
Scientists still don’t fully understand how and why long Covid occurs, but they’ve found persistent inflammation in many patients. This chronic inflammation may be caused by lingering traces of virus in the body or by misdirected antibodies, known as autoantibodies, that attack a person’s own cells and tissues. The hope is that tirzepatide could tamp down this inflammation to improve patients’ symptoms.
“The rationale for a GLP-1 drug is its powerful body-wide and brain anti-inflammatory properties,” says Eric Topol, a cardiologist and the director of the La Jolla, California-based Scripps Research Translational Institute, which is sponsoring the trial.
Scripps researchers are recruiting 1,000 people across the country who are 18 years of age or older and have medical documentation of long Covid. Unlike most medical studies, which typically require multiple in-person visits, the Scripps trial is fully remote. Participants will be randomized to receive either tirzepatide or a placebo by mail and will take it for a year. They’ll receive a fitness tracker so that researchers can measure their step count, an important indicator of fatigue. Participants will also get a smart scale and will weigh in regularly. Since GLP-1s are used for weight management, study investigators want to make sure participants don’t lose too much weight during the trial.
Julia Moore Vogel, coprincipal investigator of the trial who herself has long Covid, says the remote design of the trial was intentional. “For the long Covid population, it’s so crucial, because if you’re requiring people to come into a clinic, you’re systematically excluding the most severely affected folks who are housebound or bedbound. It was really important to us to make sure that those people are included.”
Tech
Low-grade heat from renewable sources could be used to desalinate water
A McGill University-led research team has demonstrated the feasibility of a sustainable and cost-effective way to desalinate seawater. The method—thermally driven reverse osmosis (TDRO)—uses a piston-based system powered by low-grade heat from solar thermal, geothermal heat and other sources of renewable energy to produce fresh water.
Though previous research showed promise, this study is the first to analyze TDRO’s thermodynamic limits. The results have brought researchers closer to realizing the technology which could improve access to water and increase the sustainability of infrastructure.
“Most desalination is done by reverse osmosis, which uses electricity to drive water through a membrane,” said Jonathan Maisonneuve, study co-author and Associate Professor of Bioresource Engineering.
“The challenge with using heat is that it takes a lot of it to do what you could with a little bit of electricity. So, if we can find a way to harness existing heat from renewable sources, that could be very advantageous, because it’s so abundant,” Maisonneuve said.
“Thermally driven reverse osmosis: thermodynamics of a novel process that uses heat for desalination and water purification,” by Saber Khanmohammadi, Sanjana Yagnambhatt, Dan DelVescovo and Jonathan Maisonneuve, was published in Desalination on Oct. 15, 2025.
Addressing the water and energy crises
Electricity-based desalination, which is often inaccessible in remote areas, requires about one to four kilowatt hours (kWh) to produce one cubic meter of fresh water.
According to the researchers’ analysis, which optimized several elements of a design proposed by MIT researcher Peter Godart, TDRO would require 20 kWh per cubic meter.
“There’s still a big difference when you compare it to one to four kWh, but because heat is cheaper than electricity, we don’t have to totally close that gap,” Maisonneuve said.
TDRO works by heating and cooling a small amount of fluid in a sealed chamber, known as the working fluid. This temperature fluctuation expands the working fluid, causing it to drive a piston to push seawater through a reverse osmosis membrane—effectively combining a thermodynamic cycle with water purification.
By studying and optimizing the ratio of working fluid to seawater fluid, as well as the piston sizes, the researchers demonstrated that TDRO has better performance potential than previously thought. The method also compares well against existing thermal desalination technologies, but they say further study is required.
“Next, we need to model it in detail, see how quickly the system can operate and introduce a number of non-ideal effects, such as heat loss through the environment,” Maisonneuve said.
More information:
Saber Khanmohammadi et al, Thermally driven reverse osmosis: thermodynamics of a novel process that uses heat for desalination and water purification, Desalination (2025). DOI: 10.1016/j.desal.2025.119103
Citation:
Low-grade heat from renewable sources could be used to desalinate water (2025, November 14)
retrieved 14 November 2025
from https://techxplore.com/news/2025-11-grade-renewable-sources-desalinate.html
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Tech
‘Big brother’ system designed to monitor solar plants
Using a network of synchronized sensors, a new system provides energy and meteorological data every tenth of a second to more accurately predict the performance of solar plants.
Solar plants do not always provide energy. Rather, they do so only when they can, as they depend on the weather. A single cloud, for example, can cause a drop in production.
To address the uncertainty inherent in solar plant operations, the Instrumentation and Industrial Electronics research group at the University of Cordoba has developed a new monitoring system that uses a variety of sensors to provide more detailed, precise, and synchronized information about solar plant performance. This is a Big Brother-style monitoring system designed not only to observe and predict these plants’ performance, but also to adjust the auction that sets energy prices to more realistic conditions.
The research is published in the IEEE Sensors Journal.
The goal was to analyze how solar plants generate energy in relation to weather conditions. To achieve this, the team utilized devices that have been on the market for several years, to which they applied new implementations. Thanks to these devices, the collection of equipment, which they have named Extended Phasor Measurement Units, can gather energy (such as current, voltage, and frequency) and meteorological (such as solar radiation) data.

The key is that this data is collected every tenth of a second, in great detail; so detailed, in fact, that they generate around 2 to 3 gigabytes of data each month. Furthermore, because the devices are synchronized with each other and located in different areas, including nearby solar plants, the information they provide allows us to see what has happened, and anticipate what is going to happen.
As UCO researcher Víctor Pallares López explained, “It’s about closely monitoring the systems to gather as much information as possible and being able to react to any negative effects that could affect the stability of the electrical grid.”
The more closely they are monitored, the sooner action can be taken to isolate the system from potential disturbances by disconnecting it and preventing their spread.
The sensors have been fine-tuned, tested in both the laboratory and at two Pozoblanco plants, and all the errors have been reviewed, so the team is now immersed in the second phase of the project: analyzing all the data generated.
This work is currently being conducted as part of the national project “Edge management of photovoltaic plants based on an analytical architecture with near-perfect temporal precision,” with reference PID2024-158091OB-C21.
More information:
Victoria Arenas-Ramos et al, Implementation and Characterization of a High-Precision Monitoring System for Photovoltaic Power Plants Using Self-Made Phasor Measurement Units, IEEE Sensors Journal (2025). DOI: 10.1109/jsen.2025.3598820
Citation:
‘Big brother’ system designed to monitor solar plants (2025, November 14)
retrieved 14 November 2025
from https://techxplore.com/news/2025-11-big-brother-solar.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
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Tech
Long-range EV batteries could last 2.8 times longer thanks to new gel electrolyte
A research team affiliated with UNIST has introduced a gel-like material that could extend the lifespan and enhance the safety of high-voltage electric vehicle (EV) batteries designed for long-distance driving.
This innovative electrolyte actively prevents the generation of reactive oxygen species (ROS), the primary cause of battery aging, resulting in a 2.8-fold increase in battery lifespan and a reduction in swelling by one-sixth.
Led by Professor Hyun-Kon Song from the School of Energy and Chemical Engineering at UNIST, in collaboration with Dr. Seo-Hyun Jung of the Korea Research Institute of Chemical Technology (KRICT) and Dr. Chihyun Hwang of the Korea Electronics Technology Institute (KETI), the research team developed an anthracene-based semi-solid gel electrolyte (An-PVA-CN) gel polymer electrolyte (GPE) that fundamentally blocks the release of ROS from the electrodes during high-voltage charging.
The findings have been published in Advanced Energy Materials.
High-voltage lithium-ion batteries (LIBs), charged above 4.4V, enable greater energy storage, but also pose risks. The increased voltage destabilizes oxygen in the nickel-rich cathode, converting it into ROS that produce gases, heightening the risk of explosions and shortening battery life.
The new electrolyte’s anthracene component binds with unstable surface oxygen, preventing it from forming ROS, called single oxygen (1O2), which act as seeds for further degradation. Additionally, anthracene captures and removes existing reactive oxygen, providing a dual layer of protection.
Another key component, the nitrile (-CN) group, stabilizes nickel metal in the cathode, preventing dissolution and structural deformation during charging.
First author Jeongin Lee explained, “What sets this research apart is that it directly prevents the formation of ROS at the source. Previous approaches either neutralized ROS after they formed or manipulated the electrode to suppress oxygen release.”
Batteries equipped with this electrolyte maintained 81% of their initial capacity after 500 charge-discharge cycles at a high voltage of 4.55V, whereas conventional batteries dropped below 80% capacity after only 180 cycles.
This indicates a nearly threefold increase in lifespan. Furthermore, gas evolution—and consequently, swelling—was significantly reduced; the gel electrolyte limited expansion to approximately 13 micrometers, compared to 85 micrometers in conventional batteries, achieving about a sixfold reduction.
Professor Song stated, “This study demonstrates that oxygen reactions in high-voltage batteries can be controlled at the electrolyte design stage. This principle could be applied to develop lightweight LIBs for aerospace applications and large-scale energy storage systems.”
More information:
Jeongin Lee et al, Electrolyte‐Driven Suppression of Oxygen Dimerization and Oxygen Evolution in High‐Voltage Li‐Ion Batteries, Advanced Energy Materials (2025). DOI: 10.1002/aenm.202503180
Citation:
Long-range EV batteries could last 2.8 times longer thanks to new gel electrolyte (2025, November 14)
retrieved 14 November 2025
from https://techxplore.com/news/2025-11-range-ev-batteries-longer-gel.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.
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