Connect with us

Tech

Weight-Loss Drug Zepbound Is Being Tested as a Treatment for Long Covid

Published

on

Weight-Loss Drug Zepbound Is Being Tested as a Treatment for Long Covid


Obesity wonder drugs Wegovy and Zepbound are already showing that they can reduce the risk of cardiovascular and chronic kidney disease in addition to helping people lose weight. Now, a US-wide trial will test whether tirzepatide, the active ingredient in Zepbound, may be an effective treatment for people with long Covid.

Part of a class of drugs known as GLP-1s, tirzepatide acts on receptors in the gut and the brain to regulate appetite. As a result, people shed pounds by eating less. But decreased body weight doesn’t fully explain the positive effects on the heart and kidney. Mounting evidence suggests that the drugs have a broad anti-inflammatory effect on the body—a mechanism that’s of interest for treating long Covid.

As many as 20 million people in the US have experienced long Covid, a chronic condition that lasts for at least three months after an initial infection. While more than 200 symptoms of long Covid have been documented, some of the most common include coughing, shortness of breath, brain fog, fatigue, mood changes, trouble sleeping, and body aches.

Scientists still don’t fully understand how and why long Covid occurs, but they’ve found persistent inflammation in many patients. This chronic inflammation may be caused by lingering traces of virus in the body or by misdirected antibodies, known as autoantibodies, that attack a person’s own cells and tissues. The hope is that tirzepatide could tamp down this inflammation to improve patients’ symptoms.

“The rationale for a GLP-1 drug is its powerful body-wide and brain anti-inflammatory properties,” says Eric Topol, a cardiologist and the director of the La Jolla, California-based Scripps Research Translational Institute, which is sponsoring the trial.

Scripps researchers are recruiting 1,000 people across the country who are 18 years of age or older and have medical documentation of long Covid. Unlike most medical studies, which typically require multiple in-person visits, the Scripps trial is fully remote. Participants will be randomized to receive either tirzepatide or a placebo by mail and will take it for a year. They’ll receive a fitness tracker so that researchers can measure their step count, an important indicator of fatigue. Participants will also get a smart scale and will weigh in regularly. Since GLP-1s are used for weight management, study investigators want to make sure participants don’t lose too much weight during the trial.

Julia Moore Vogel, coprincipal investigator of the trial who herself has long Covid, says the remote design of the trial was intentional. “For the long Covid population, it’s so crucial, because if you’re requiring people to come into a clinic, you’re systematically excluding the most severely affected folks who are housebound or bedbound. It was really important to us to make sure that those people are included.”



Source link

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Tech

Welcome to the Future of Noise Canceling

Published

on

Welcome to the Future of Noise Canceling


This blurring of the lines between audio and health devices looks set to be a trend across the industry. “We really want to make sure that we take care of our customers’ hearing,” says Miikka Tikander, the Helsinki-based head of audio at Bang & Olufsen. Tikander points to recent data about the decline in hearing health in young adults and reports that there was a lot of emphasis from manufacturers on ANC and hearing health at the AES’ Headphone Technology conference in Espoo, Finland this August.

“Apple has a big lead in that area,” he says. “We want to make sure that our headphones can adapt, make this choice [on when to block out sound] on your behalf, if you let it, of course. Some people don’t like that idea, but if there’s a noisy event in your surroundings, the headset can take care of it, just tune it out a bit and get you back to normal listening once you are away from that noise.”

Enter the “Sound Bubble”

Hearvana AI is one startup looking to go much further than the AirPods’ current suite of noise canceling and ambient noise features. Cofounded by Shyam Gollakota, a computer science & engineering professor at the University of Washington, and two of his students, Malek Itani and Tuochao Chen, Hearvana recently raised $6 million in a pre-seed round which included none other than Amazon’s Alexa Fund.

One of the startup’s first big innovations was “semantic hearing,” which was the first project they approached, around three years ago. The team built a hardware prototype—a pair of on-ear headphones with six microphones across the headband, connected to an Orange Pi microcontroller—to test out a model that had been trained to recognize 20 different types of ambient sounds. This included things like sirens, car horns, birdsong, crying babies, alarm clocks, pets, and people talking, and then allowed the user to isolate say, one person’s voice as a “spotlight,” and block out all the other frequencies.

“So I’m going to the beach and I want to listen to just ocean sounds and not the people talking next to me, or I’m in the house vacuum cleaning but I still want to listen to people knocking on the door or important sounds, like a baby crying,” explains Gollakota, who is based in Seattle. “And that’s what we solved first. This was the difference between a vacuum cleaner and a door knock. They sound pretty different, right?”



Source link

Continue Reading

Tech

Looking for the Best Smart Scale? Step on Up

Published

on

Looking for the Best Smart Scale? Step on Up


Other Smart Scales

Renpho MorphoScan

Photograph: Chris Null

Renpho MorphoScan for $150: The Renpho MorphoScan full-body scanner looks surprisingly similar to the Runstar FG2015, including a near-identical display attached to the handlebars. Well, spoiler alert, they are basically the same scale. They even use the same app to collect data (and you can even use both scales simultaneously with it). The only reason this scale isn’t our top pick for the category is that it’s $15 more expensive. You can rest assured that a price war is looming.

Black digital scale with small screen

Arboleaf Body Fat Scale CS20W

Photograph: Chris Null

Arboleaf Body Fat Scale CS20W for $40: This affordable Bluetooth scale isn’t the most eye-catching I’ve tested, owing to its big, silver electrodes and an oversized display that comes across as a bit garish. While weight is easy to make out, the six additional statistics showcased are difficult to read, all displayed simultaneously. I like the Arboleaf app better than the scale, where five more metrics can be found in addition to the seven above, each featuring a helpful explanation when tapping on it. It’s a solid deal at this price, but the upsell to get an “intelligent interpretation report” for an extra $40 per year is probably safe to skip.

Image may contain Electronics Phone Mobile Phone Computer Laptop and Pc

Hume Health Body Pod

Photograph: Chris Null

Hume Health Body Pod for $183: Hume Health’s Body Pod, another full-body scanner with handles, is heavily advertised—at least to the apps on my phone—and touted (by Hume) as the Next Big Thing in the world of body management. While the app is indeed glossy and inviting, I was shocked to discover how flimsy the hardware felt, that it lacked Wi-Fi, and that some features are locked behind a $100-a-year Hume Plus subscription plan. It works fine enough, but you can get results that are just as good with a cheaper device.

Garmin Index S2 for $191: Five years after its release, the Index S2 is still Garmin’s current model, a surprise for a company otherwise obsessed with fitness. It’s still noteworthy for its lovely color display, which walks you through its six body metrics (for up to 16 users) with each weigh-in. The display also provides your weight trend over time in graphical form and can even display the weather. The scale connects directly to Wi-Fi and Garmin’s cloud-based storage system, so you don’t need a phone nearby to track your progress, as with Bluetooth-only scales. A phone running the Garmin Connect app (Android, iOS) is handy, so you can keep track of everything over time. Unfortunately, as health apps go, Connect is a bit of a bear, so expect a learning curve—especially if you want to make changes to the way the scale works. You can turn its various LCD-screen widgets on or off in the app, but finding everything can be difficult due to the daunting scope of the Garmin ecosystem. The color screen is nice at first, but ultimately adds little to the package.

Omron BCM-500 for $92: With its large LCD panel, quartet of onboard buttons, and oversize silver electrodes, the Omron BCM-500 is an eye-catching masterwork of brutalist design. If your bathroom is decked out in concrete and wrought iron, this scale will fit right in. The Bluetooth unit syncs with Omron’s HeartAdvisor app (Android, iOS), but it provides all six of its body metrics directly on the scale, cycling through them with each weigh-in (for up to four users). It can be difficult to read the label for each of the data points, in part because the LCD isn’t backlit, but the app is somewhat easier to follow, offering front-page graphs of weight, skeletal muscle, and body fat. On the other hand, the presentation is rather clinical, and the app is surprisingly slow to sync. For a scale without a Wi-Fi connection, it’s rather expensive too.


Power up with unlimited access to WIRED. Get best-in-class reporting and exclusive subscriber content that’s too important to ignore. Subscribe Today.



Source link

Continue Reading

Tech

To Start Doing What You Want to Do, First Do Less

Published

on

To Start Doing What You Want to Do, First Do Less


This applies not just to things you have to do, but also things you think you want to do. Maybe you think you should learn Spanish, but you haven’t done anything to actually learn Spanish. Admitting that you aren’t actually committed to the idea enough to do the work of learning Spanish can help close that loop. Letting go of that feeling that you should learn Spanish just might be the thing that frees up your mind enough that you decide to take up paddleboarding on a whim. The point is that the new year isn’t just a time for starting something new. It’s a time to let go of the things from that past that are no longer serving you.

In many ways this is the antidote to that ever-so-popular slogan “Just do it.” Just do it implies that you shouldn’t think about it, instead of deciding what you really want to do or should do. Maybe spend some time remembering why you wanted to do it in the first place, and if those reasons no longer resonate with you, just don’t do it.

If you like this idea, I highly recommend getting Allen’s book. It goes into much more detail on this idea and has some practical advice on letting go. You can still keep track of those things, in case you do decide, years from now, when you’re paddleboarding through the Sea of Cortez, that now you really do want to learn Spanish and are willing to do the work.

Remember to Live

I will confess, my enthusiasm for Getting Things Done has waned over the years. Not because the system doesn’t work, but because I have found my life more dramatically improved by doing less, not more. It’s not that I’ve stopped getting things done. It’s that I’ve found many of the things I felt like I should do were not really my idea; they were ideas I’d internalized from other places. I didn’t really want to do them, so I didn’t, then I felt guilty about it.

While everything I’ve written above remains good advice for starting a healthy habit and keeping it going, it’s worth spending some time and making sure you know why you want to do what you’re doing. I have been rereading Bertrand Russell’s In Praise of Idleness, and this line jumped out at me: “The modern man thinks that everything ought to be done for the sake of something else, and never for its own sake.”



Source link

Continue Reading

Trending