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A Billionaire-Backed Startup Wants to Grow ‘Organ Sacks’ to Replace Animal Testing

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A Billionaire-Backed Startup Wants to Grow ‘Organ Sacks’ to Replace Animal Testing


As the Trump administration phases out the use of animal experimentation across the federal government, a biotech startup has a bold idea for an alternative to animal testing: nonsentient “organ sacks.”

Bay Area-based R3 Bio has been quietly pitching the idea to investors and in industry publications as a way to replace lab animals without the ethical issues that come with living organisms. That’s because these structures would contain all of the typical organs—except a brain, rendering them unable to think or feel pain. The company’s long-term goal, cofounder Alice Gilman says, is to make human versions that could be used as a source of tissues and organs for people who need them.

For Immortal Dragons, a Singapore-based longevity fund that’s invested in R3, the idea of replacement is a core strategy for human longevity. “We think replacement is probably better than repair when it comes to treating diseases or regulating the aging process in the human body,” says CEO Boyang Wang. “If we can create a nonsentient, headless bodyoid for a human being, that will be a great source of organs.”

For now, R3 is aiming to make monkey organ sacks. “The benefit of using models that are more ethical and are exclusively organ systems would be that testing can be meaningfully more scalable,” Gilman says. (R3’s name comes from the philosophy in animal research known as the three R’s—replacement, reduction, and refinement—developed by British scientists William Russell and Rex Burch in 1959 to promote humane experimentation.)

New drugs are often tested in monkeys before they’re given to human participants in clinical trials. For instance, monkeys were critical during the Covid-19 pandemic for testing vaccines and therapeutics. But they’re also an expensive resource, and their numbers are dwindling in the US after China banned the export of nonhuman primates in 2020.

Animal rights activists have long pushed to end research on monkeys, and one of the seven federally funded primate research facilities across the country has signaled it would consider shutting down and transitioning into a sanctuary amid growing pressure. The US Centers for Disease Control and Prevention is also winding down monkey research, part of a bigger trend across the government to reduce reliance on animal testing.

As a result, Gilman says, there aren’t enough research monkeys left in the US to allow for necessary research if another pandemic threat emerges. Enter organ sacks.

Organ sacks would in theory offer advantages over existing organs-on-chips or tissue models, which lack the full complexity of whole organs, including blood vessels.

Gilman says it’s already possible to create mouse organ sacks that lack a brain, though she and cofounder John Schloendorn deny that R3 has made them. (For the record, Gilman doesn’t like the term “brainless” to describe the organ sacks. “It’s not missing anything, because we design it to only have the things we want,” she says.) Gilman and Schloendorn would not say how exactly they plan to create the monkey and human organ sacks, but said they are exploring a combination of stem-cell technology and gene editing.

It’s plausible that organ sacks could be grown from induced pluripotent stem cells, says Paul Knoepfler, a stem cell biologist at the University of California, Davis. These stem cells come from adult skin cells and are reprogrammed to an embryonic-like state. They have the potential to form into any cell or tissue in the body and have been used to create embryo-like structures that resemble the real thing. By editing these stem cells, scientists could disable genes needed for brain development. The resulting embryo could then be incubated until it grows into organized organ structures.



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Inside the Race to Develop a Test for the Rare Andes Hantavirus

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Inside the Race to Develop a Test for the Rare Andes Hantavirus


As passengers return to the US from the cruise that saw a rare hantavirus outbreak, much of the country is lacking a basic public health tool: a test to diagnose the illness in the earliest stages of infection. Nebraska may be the first state with the ability to do so.

In just a few days, a lab at the University of Nebraska Medical Center in Omaha developed its own diagnostic test for the Andes virus in anticipation of receiving 16 American passengers from the ship.

“I believe we might be the only lab in the nation that has this test available at the moment,” Peter Iwen, director of the Nebraska Public Health Laboratory tells WIRED, referring to polymerase chain reaction (PCR) testing, which was important during the Covid-19 pandemic. Its ability to detect tiny quantities of the virus before patients have full-blown symptoms makes it crucial for identifying cases quickly, getting patients prompt medical treatment, and preventing the spread of disease.

The university’s medical center is home to a highly specialized biocontainment unit designed to care for patients with severe infectious diseases that lack vaccines or treatments. Staff members previously treated patients during the 2014 Ebola outbreak and cared for some of the first Americans diagnosed with Covid in 2020.

When Nebraska was notified that it would be receiving some of the passengers, Iwen contacted the US Centers for Disease Control and Prevention to see if it had tests on hand. He learned that the CDC has the ability to run a serological test, which looks for the presence of hantavirus antibodies. But people don’t develop antibodies until they are actively sick and their body has had time to mount an immune response.

Andrew Nixon, a spokesperson for the US Department of Health and Human Services, told WIRED that the CDC has a PCR test for the Andes virus but that it’s a research test that cannot be used for patient management. Research tests are used in scientific experiments, while diagnostic tests that are meant to confirm or rule out a disease in patients need to be rigorously tested, or validated, to make sure they are capable of producing consistent results. Nixon said the agency is working on validating its PCR test.

Iwen’s lab mobilized quickly to track down the materials needed to build and validate a PCR test from scratch. They called a lab in California—a state that has previously seen hantavirus cases—but their test was for a specific strain found in the US. Andes virus has previously only been detected in South America and isn’t found in rodents native to the US.

“Tests that we have available in the US will not detect that virus that’s found in South America,” he says, noting that the Andes virus is very different genetically from the primary hantavirus strain found in the US, known as the Sin Nombre virus.

The Nebraska team reached out to Steven Bradfute, a hantavirus scientist at the University of New Mexico. Frannie Twohig, a graduate student in Bradfute’s lab, had developed an Andes virus PCR test for research purposes as part of her PhD work. Bradfute’s lab also has genetic material of the Andes virus that’s not capable of causing disease which the Nebraska lab would need to validate its test.

On Friday, Bradfute shipped the genetic material and a box of chemical reagents needed to detect the virus in blood samples overnight to Nebraska. By Saturday morning, Iwen’s team had what it needed to start assembling and validating its test.

It was enough to run about 300 tests, which took all day Saturday and Sunday, Iwen says. His team added Andes genetic material in various concentrations to samples of healthy human blood to see if their test could detect it. Then, they compared the results to control samples. The team used up about a third of its tests on the validation process and now has the capacity to conduct a few hundred tests on patient samples.



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Via Africa subsea cable project to strengthen European, African connectivity | Computer Weekly

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Via Africa subsea cable project to strengthen European, African connectivity | Computer Weekly


A subsea infrastructure project, Via Africa, has been unveiled to strengthen connectivity between Europe and Africa, aiming to enhance the resilience and diversity of West Africa’s international communications.

The Via Africa project will comprise a submarine cable system that will connect Europe to Africa along the Atlantic coast, and provide a subsea route alongside existing infrastructure at a time when, says the consortium, demand for cloud services, artificial intelligence (AI) workloads and international traffic is rapidly increasing across the continent.

The communications system aims to connect Europe to South Africa – including landing points in the UK, France and Portugal – with destinations along the Atlantic coastline such as the Canary Islands, Mauritania, Senegal, Guinea, Côte d’Ivoire and Nigeria. Including extensions further south, the net result will be to contribute to greater diversity and resilience of international connectivity serving Africa, by providing a different subsea route than existing infrastructure and strengthening the robustness of regional connectivity.

It will operate under a consortium model, and participating operators will be able to co-invest in the infrastructure and play a direct role in governance, deployment and future operation. By being managed as a consortium, the project is seen as enabling participating partners seeking autonomy and sovereignty to co-invest in the infrastructure and take part in its governance.

They add that such a “robust and proven” model allows investors to participate directly in the decisions regarding the design, deployment and exploitation of the system, and contribute to decisions that best meet their needs.

Major investors that have a signed a memorandum of understanding to initiate the scheme include major European telcos Vodafone and Orange Group, as well as Guilab, International Mauritania Telecom, Orange Côte d’Ivoire, Silverlinks, Senegalese operator Sonatel, and Canalink, whose business connects Africa, the Canary Islands and Europe.

The partners say they have a shared ambition to develop international connectivity, to support traffic growth and to strengthen the resilience of networks across the African continent. The initial telco and digital player partners say they are open to additional partners potentially joining the project in the future.

As part of the initial phase of the project, consortium members will jointly finance a cable route study to identify the optimal cable route that balances resilience, technical feasibility and overall economic efficiency. In parallel, the consortium is preparing the procurement process for selecting a cable supplier, marking the next step in the development of the system.

On behalf of Orange, Via Africa adds to the Medusa Submarine Cable System, designed to transform infrastructure in the Mediterranean region. Owned by African infrastructure and telecoms operator AFR-IX Telecom, and which made its first landing on European soil in October 2025, Medusa is 8,760km long, and will be the first and longest subsea cable to connect the main Mediterranean countries, providing access to telecommunications infrastructure and 16 landing points around the Mediterranean Sea.

Operationally, Medusa has two main regions: Europe and North Africa. In Europe, it has local operational branches in Ireland, Portugal, Spain, France, Italy, Greece and Cyprus. These branches hold licenses and permits. The Network Operations Centre is based in Europe. In North Africa, Medusa has agreements with local licensed operators for landing parties.

Medusa is seen as being crucial for developing the digital ecosystem of populations in North African countries, taking a significant step towards closing the digital divide between Europe and North Africa, connecting countries such as Morocco, Tunisia, Libya, Algeria and Egypt with high-capacity fibre-optic links to six European Union member states: Portugal, Spain, France, Italy, Greece and Cyprus.



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NASA’s Curiosity Rover Got Its Drill Stuck on a Rock. Here’s How They Freed It

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NASA’s Curiosity Rover Got Its Drill Stuck on a Rock. Here’s How They Freed It


While it has enabled many exciting discoveries, the Curiosity Rover has also encountered its share of setbacks. The latest left NASA engineers speechless.

On April 25, Curiosity drilled into a rock nicknamed “Atacama” to collect a sample. When the rover retracted the robotic arm after drilling, the entire rock unexpectedly lifted off the Martian surface—all 28.6 pounds of it. While other Curiosity drilling operations have caused cracks or breaks in the upper layers of Martian rocks during the rover’s nearly 14-year mission, this is the first time one has remained stuck to the sleeve that surrounds the drill’s rotating tip.

As the space agency itself recounts, it was the black-and-white obstacle-detection cameras mounted on the front of the rover’s chassis that captured this peculiar “accident” in a sequence of images that allowed engineers to get to work immediately to free it, moving its robotic arm and operating the drill repeatedly over several days.

Engineers initially tried to remove the rock by vibrating the drill, to no avail. On April 29, they adjusted the position of the robotic arm and tried vibration again, but only managed to knock some sand off the rock. On May 1, the team gave it another try by tilting the drill more, rotating and vibrating it, and spinning the drill bit. The team expected to have to repeat these operations several times, but instead the rock broke loose on the first attempt, shattering into a multitude of pieces when it hit the Martian soil.

NASA’s Curiosity rover was developed by the Jet Propulsion Laboratory and landed on Mars in August 2012 with the purpose of looking for evidence that the Red Planet might have once had conditions that could support microbial life. In 2020, it conducted an experiment in the Glen Torridon region within Gale Crater, an area rich in clay minerals that strongly indicate the presence of water in the past and that it collected using onboard instruments known as Sample Analysis on Mars.

This story originally appeared in WIRED Italia and has been translated from Italian.



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