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Data Holds the Key in Slowing Age-Related Illnesses

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Data Holds the Key in Slowing Age-Related Illnesses


In 2026, we will see the beginning of precision medical forecasting. Just as there have been remarkable advances in weather forecasting with the use of large language models, so will there be for determining an individual’s risk of the major age-related diseases (cancer, cardiovascular, and neurodegenerative). These diseases share common threads, such as a long incubation phase before any symptoms are manifest, usually two decades or more. They also have the same biologic underpinnings of immunosenescence and inflammaging, terms that characterize an immune system that has lost some of its functionality and protective power, and the accompanying heightened inflammation.

The science of aging has given us new ways to track these processes with body-wide and organ clocks, along with specific protein biomarkers. That enables us to determine whether a person or an organ within a person is aging at an accelerated pace. Along with that, new AI algorithms can see things that medical experts cannot, such as accurately interpreting medical images like retinal scans to predict cardiovascular and neurodegenerative diseases many years in advance.

These added layers of data can be combined with a person’s electronic medical records, which include their structured and unstructured notes, lab results, scans, genetic results, wearable sensors, and environmental data. In aggregate, this provides an unprecedented depth of information about the person’s health status, enabling a forecast for risk of the three major diseases. Unlike a polygenic risk score which can detect a person’s risk for heart disease, the common cancers and Alzheimer’s, precision medical forecasting takes it to a new level by providing the projected temporal arc—the “when” factor. When all of the data is analyzed with large reasoning models, it can provide a person’s vulnerabilities, and an individualized, aggressive preventive program.

We already know the risk of these three diseases can be reduced with lifestyle factors, such as an optimal anti-inflammatory diet, frequent exercise, and a regular, high-quality sleep pattern. But, along with attention to these factors, which are far more likely to be implemented when an individual is cognizant of their risk, we will have medications that will promote a healthy, protective immune system and reduce body-wide and brain inflammation. Already the GLP-1 medicines have been shown to be a front-runner for achieving these goals, but many more medications are in the pipeline.

The potential for precision medical forecasting has to be demonstrated and validated via prospective clinical trials that show, using the same metrics of aging, that a person’s risk is decreased. An example for people with increased risk of Alzheimer’s is the blood test known as p-tau217, and that risk can be markedly reduced with improved lifestyle factors, especially exercise. That could be confirmed with a brain organ clock and body-wide aging clocks.

This is a new frontier in medicine—the potential for primary prevention of the three age-related major diseases that compromise our health span and quality of life. It would not be possible without the advances in both the science of aging and AI. For me, this is the most exciting future use of AI in medicine: an unparalleled opportunity to prevent the major diseases from occurring, something that has been dreamed about but has not been possible at scale due to the deficiency in data and analytics. In 2026, it finally will.



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I’ve Been Waiting Months for This Gorgeous Laptop to Drop in Price. It Finally Happened

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I’ve Been Waiting Months for This Gorgeous Laptop to Drop in Price. It Finally Happened


After a long time of resisting significant price drops, the Asus Zenbook S 16 has finally dropped down to $1,000, which is $500 off its retail price.

It’s normal for laptops to dip in price toward the end of their lifespan, close to when an update comes out. But the Asus Zenbook S 16 has held on. To be fair, it’s an extremely high-end Windows laptop, one of the prettiest to come out last year. It’s sleek, portable, and has a striking design. It even gets fantastic battery life, on par with a MacBook. Speaking of MacBooks, this Zenbook is the laptop I saw tech journalists traveling with more than anything else. Given how much tech they review, that’s quite an endorsement.

But the S 16 has always been hard for me to recommend when the cheapest model available was $1,500. I was always on the lookout for a more significant price cut, but it never dropped more than a couple hundred bucks. And even though it always came with 24 GB of RAM and a terabyte of storage, the price was a hard pill to swallow. Well, the day has finally come. It’s now down to $1,000 over at Best Buy as part of the store’s Presidents’ Day sale. That’s an incredible price for this much laptop.

Photograph: Christopher Null

Asus

Zenbook S 16 (UM5606)

The previously mentioned memory and storage still apply here, along with the 2880 x 1800 OLED display with a 120-Hz refresh rate. This laptop basically has every high-end feature you could imagine, but one of my favorite aspects is the ports. Despite the thin profile, the S 16 keeps all the legacy ports you might want, including HDMI, USB-A, and even a full-size SD card slot.

There is also a smaller, 14-inch model, but its discount is not as strong as the 16-inch model. It comes in at $1,300 right now, which is still a solid price for this configuration.

I should say that Asus has an update in the works for 2026 with the latest Intel chips, but it’s only coming to the 14-inch model. I won’t lie: Based on my testing, these CPUs will make a significant difference in performance—especially on the graphics front. But I have a feeling Asus will be selling this device for an even higher price for much longer, especially with the recent development around memory shortage.

While the Zenbook S 16 is certainly the best deal at Best Buy for its Presidents’ Day sale, I would also recommend the Asus Zephyrus G14, which is also $500 off. This configuration comes with a powerful RTX 5070 Ti graphics card and is one of our favorite gaming laptops.



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‘Uncanny Valley’: ICE’s Secret Expansion Plans, Palantir Workers’ Ethical Concerns, and AI Assistants

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‘Uncanny Valley’: ICE’s Secret Expansion Plans, Palantir Workers’ Ethical Concerns, and AI Assistants


Brian Barrett: They’ve got 80 billion or so to spend 75 billion of that I think they have to spend in the next four years. So yeah, they’re going to keep expanding. And when you think of how much of an impact 3000 agents officers had in Minneapolis alone, that’s like an eighth of the, they can repeat some version of that in a lot of different spots.

Leah Feiger: And I’ve been fielding, honestly, shout out to the many local reporters around the country who’ve been contacting me in the last day or so, just to ask questions about the locations that we named that are near them or in their states or cities. And the thing to me that keeps coming up is that in addition to new buildings, they’re getting put into preexisting government buildings, preexisting leases, or that that appears to be the plan. And then we’ve also found that a bunch of these ICE offices are being located near plans for giant immigration detention warehouses, and we’re looking at offices being set up, say 20 minutes, an hour and 20 minutes away for these. Yeah. So we’re looking at different, the triangulation of this around you have to have your lawyers, your agents, have a place to get their orders and put their computers and do in some ways very mundane things that are required of an operation like this one.

Brian Barrett: Well, Leah, that’s a good point. I think when people hear ICE offices or when I do just instinctively, I think of ICE as guys with guns and masks and all that, but that’s not exactly what we’re saying here. Do you mind talking through what these offices seem to be queued up to be used for and by whom? Because ICE is not just the masked guys with bad tattoos.

Leah Feiger: Yes, absolutely. So what we reported in this story as well was some of the specific parts of ICE that actually reached out to GSA and asked them to expedite the process of getting new leases, et cetera, included in that, for example, where representatives from Ola, Ola is ICE’s office of the principal legal advisor. So that’s the lawyers, those are the ICE lawyers that are working with the courts and arguing back or deportation orders saying yes, no, et cetera, signing the documents, putting everything in front of judges. This is a really important part of this entire operation that we’re not talking about a ton. There’s a lot of focus on the DOJ. There’s a lot of focus. There was an excellent article this week in Politico talking about all of these federal judges that are really, really upset that DHS and ICE are ignoring their requests for immigrants to not be detained anymore.

The missing level of that is the lawyers that are part of this that are representing ICE to the US government here, and that’s ola. So they’ve reached out to GSA extensively as we report to get these leasing locations, specifically with the OLA legal request. I just want to get across how big this is. How massive is this ICE repeatedly outlined its expansion to cities around the us And this one piece of memorandum that we got from Ola stated that ICE will be expanding its legal operations into Birmingham, Alabama, Fort Lauderdale, Fort Myers, Jacksonville, and Tampa, Des Moines, Iowa, Boise, Idaho, Louisville, Kentucky, Baton Rouge, Louisiana, grand Rapids, Michigan, St. Louis, Missouri, rally, North Carolina, long Island, New York, Columbus, Ohio, Oklahoma City, Oklahoma, Pittsburgh, Pennsylvania, Charleston and Columbia, South Carolina, Nashville, Tennessee, Richmond, Virginia, Spokane, Washington and Cord Delaine, Idaho and Milwaukee, Wisconsin. We have other locations as well throughout the rest of the article, but those are the requests from OLA.



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Waymo Asks the DC Public to Pressure Their City Officials

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Waymo Asks the DC Public to Pressure Their City Officials


Waymo needs some help, according to an email message the self-driving developer sent to residents of Washington, DC, on Thursday.

For more than a year, Waymo has been pushing city officials to pass new regulations allowing its robotaxis to operate in the district. So far, self-driving cars can test in the city with humans behind the wheel, but cannot operate in driver-free mode. The Alphabet subsidiary—and its lobbyists—have asked local lawmakers, including Mayor Muriel Bower and members of the city council, to create new rules allowing the tech to go truly driverless on its public roads. The company has previously said it will begin offering driverless rides in DC this year.

But Waymo’s efforts to sway officials have stalled, so the company is now asking residents to apply some pressure. “We are nearly ready to provide public Waymo rides to everyone in DC,” says an email sent to those who have signed up for Waymo’s DC service. “However, despite significant support, District leadership has not yet provided the necessary approvals for us to launch.”

The email directs recipients to contact DC officials via a form letter that says, in part: “Over the past year, I have observed Waymo vehicles operating throughout our local areas, and I am thrilled about the potential advantages this service could provide, including enhanced accessibility and a decline in traffic-related incidents.” The communication urges DC residents to edit the letter to “use your own words,” because personalized messages “have a higher impact.” Only DC residents or those with DC addresses can participate, Waymo says.

In a written statement, Waymo spokesperson Ethan Teicher says, “We’ll be ready to serve Washingtonians this year, and urge the Mayor, the District Department of Transportation, and the City Council to act.” The company says that 1,500 people contacted district leaders through its email in the first 90 minutes after it was sent.

Generally, self-driving vehicle developers have only launched service in places where regulations clearly outline how the tech might hit the roads. Other US cities with Waymo service, including ones in California, Florida, and Texas, already had those rules in place before the company entered their markets. But as Waymo’s ambitions have grown larger, it has begun to target large blue-state cities where autonomous vehicle tech doesn’t yet have a “driver’s license.” Earlier this month, the company said it would begin testing in Boston, where city lawmakers pushed last year for an ordinance that would ban self-driving taxis from operating without a human behind the wheel. Waymo has said that it needs Massachusetts lawmakers to “legalize fully autonomous vehicles” before it can launch service in Boston.

Eventually, self-driving-vehicle developers hope that the US Congress will pass a law allowing the broader testing and operation of their tech across the US. On Tuesday, a House committee advanced a bill that would direct the federal government to create safety standards for autonomous vehicles, and prevent states from passing their own laws prohibiting the sale or use of the tech, or from requiring companies to submit information on crashes.

Waymo’s new DC pressure campaign echoes the ones launched by transportation disrupters, including ride-hailing giant Uber and bike- and scooter-share company Bird, nearly a decade ago. Like self-driving tech developers, those companies wanted to launch their new services in places where the rules didn’t align with their business ambitions. Ultimately, Uber and Lyft generally succeeded in getting laws passed in US statehouses allowing their services to operate on public roads—and preventing cities from creating their own laws.

Today, Waymo operates in six US metro areas—Atlanta, Austin, Los Angeles, Miami, Phoenix, and the San Francisco Bay Area—and plans to launch in more than 10 this year. Three other companies, including Nuro and Amazon-owned Zoox, have permits to test self-driving tech in Washington, DC.



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