Tech
I Tried the Best At-Home Pet DNA Test Kits on My Two Cats
If You Have a Dog, Consider These Kits
I don’t have a dog, so I didn’t try these at-home DNA test kits for dogs, but these are the kits specifically for dogs from Basepaws and Wisdom Panel, the two companies I’ve tested for my cats.
How Does a DNA Testing Kit Work?
Pet DNA tests rely on pet owners collecting cells for testing through a cheek swab, where the sample is put into a sealed stabilizing or preserving fluid for transit. You’ll mail the sample back to the lab in the prepaid envelope. It takes up to five weeks to get results. (The first time I sent my cat Basil’s Basepaws sample, the company emailed that the results were inconclusive, and I had to wait for another kit to be sent, re-swab him, and wait another five weeks for results.)
At the lab, the sample is analyzed against the company’s breed and genetic health database. They use single nucleotide polymorphism (SNP) arrays—the standard technology used to identify breed ancestry—as well as various inherited traits and risk of common diseases. Essentially, different breeds have distinct patterns of SNPs in their genomes, which act as the genetic markers. These tests analyze the pet’s DNA sample for specific SNPs and then compare them to the company’s existing database to estimate the composition of breed types in the animal. This not only tells you about breed composition, but can also identify the specific DNA sequences that are markers for potential health risks, like predispositions to diseases or hereditary cancers.
Don’t take the health or DNA test results as absolute truth, however. “This can lead to a false sense of security or false alarms,” says veterinarian Amanda Chambers. Forward your results to your veterinarian and always follow up with scheduling a visit to the vet if your pet is marked as a carrier for any genetic disease.
Limitations of At-Home DNA Test Kits
After chatting with Jamie Richardson, head of veterinary medicine at Small Door Veterinary, I’ve found that these are the major areas of limitations with at-home DNA test kits:
- Results depend on the size/diversity of the genetic database
- Most kits test known markers only—not full genomes
- Feline data is less developed
- Misinterpretation of results can lead to unnecessary concern
How Accurate Is At-Home DNA Testing?
Wisdom Panel claims its breed results for cats are over 98 percent accurate and that tests for dogs are over 99 percent accurate.
I’ve outlined the results below, so you can see the disparity in results from the two kits I tested, particularly with breed ancestry.
One problem with the vast disparity in results is that the two companies have different sample sizes and metrics for identifying breeds. But the biggest issue for cat owners taking these at-home DNA tests is that you can’t really identify most cats’ breeds the way you can with dogs. Unless your cat is a purebred, around 95 percent of cats don’t belong to a recognized breed. Cats’ genetic backgrounds are muddied—they’re just similar mixes with different physical characteristics, so the tests only show the breed(s) they share the most markers with. Basically, these tests for cats aren’t able to reliably tell us about breed composition, just similarity to other breeds’ traits in the company’s data pool.
From my research, it seems the breed identification part of these tests is more accurate for dogs, as dog DNA is so much more diversified. Breeds have been clearly defined after centuries of diversifying from other breeds, and dog DNA mutates quickly, with genes changing quickly after just a few generations. Cats are not much different from their Egyptian ancestors.
Interestingly, in this report from CBS in 2023, the news organization sent dog and human DNA to different at-home test companies and got various results, ranging from 65 to only 29 percent German shepherd DNA for the dog. The human DNA results were attributed to a bulldog, border collie, and cane corso mix.
TL;DR
There isn’t one catch-all way to determine a pet’s genetic makeup or ancestry. Humans like categories. And breeds are essentially human constructs, based on the way the dog or cat looks. The genetic part of the test is fun, but take it with a grain of salt—especially with cats.
Ancestry Results
If you read above, you know that there’s a significant disparity in results based on the pool the sample is compared against.
For example, below are the results I got for my cat Clover, who’s a dilute calico with long, white fur and visually looks most like a Maine coon or Norwegian forest cat.
(I also tested my run-of-the-mill gray cat Basil, but he was almost entirely “American domestic cat” and “polycat/domestic shorthair”—basically the mutt final boss, a result of many generations of mixed breeding between different types of cats, where ancestry and origin is almost impossible to determine.)
Health Results
Wisdom Panel tests for 49 genetic health predispositions by comparing the pet’s DNA against a panel of cat or dog genetic health checks. It tests for the top five genetic conditions that could impact the pet’s vet visits—essentially, the most common conditions that are seen in cats or dogs with a similar breed makeup as your pet. These are for things like drug sensitivity, immune deficiency, and bleeding disorders. They also identified the cat’s blood type (both of my cats were A) and transfusion risk (both were moderate).
Basepaws tests for up to 115 health markers, but my cat received results for only 44 genetic diseases (owners are encouraged to check results often in case missing markers are added as more data becomes available). This list felt more in-depth than the Wisdom Panel test, testing genes for markers against disorders in musculoskeletal and connective tissue; eyes; metabolic, autoimmune, and endocrine systems; blood; and more. Both of my cats, Clover and Basil, were cleared as having none of the genes that mark them as potential carriers of genetic diseases. It also identified blood type and transfusion risk, which were A and moderate (the same results I got with Wisdom Panel’s test).
If your pet gets flagged for any of these results, don’t panic. “The presence of a certain gene does not always mean a patient will develop a certain disorder that is associated with that gene—it just means they’re at higher risk of it. I would encourage owners to reach out to their veterinarian if they have questions after receiving the results of a DNA test,” says Chambers.
Oral Health Results
Wisdom Panel doesn’t screen for oral health, which is a huge problem in many pets, and can lead to tooth extraction and bigger health issues.
Oral health was a concern for me, and Basepaws tests for oral health by testing against an oral microbiome database. In this regard, Basepaws wins out.
According to the Basepaws results, Clover was a low risk for periodontal disease and tooth resorption, but at a high risk of halitosis. The report said bad breath could be indicative of a larger health issue, but she was cleared for disease, so I wasn’t sure what to do with that information.
Courtesy of Molly Higgins
My other cat, Basil, was at high risk for all the dental markers mentioned above, and Basepaws came up with a health plan for him: “adopt a daily oral healthcare routine, consider supplementing Basil’s routine with products accepted by the Veterinary Oral Health Council, and schedule an appointment with your veterinarian in the next month.”
Courtesy of Molly Higgins
Although I was alarmed at the results, I liked that Basepaws gave me recommended next steps so I could come up with a plan of action for care. And it’s important to remember that these results don’t necessarily mean a pet is guaranteed to develop the disease.
“These can be a helpful flag for your veterinarian to keep an eye on […] but does not necessarily mean aggressive testing is needed at that moment,” says Richardson. “DNA tests are tools to support—not replace—veterinary care.”
Traits Results
Both of the tests had this section, which tests for coat color traits and variants, but I found it mostly useless. Wisdom Panel’s assertions of both cats’ physical traits were correct. But with Basepaws, Clover, a dilute calico, was marked as being likely black in color.
I can see with my eyes what my cat(s) look like, but if you’re a genetic nerd, this might be fun to see what the actual DNA reflects.
A Note on At-Home Allergy Testing Kits
I recently tested both of my cats for their allergies and intolerances using a similar at-home test kit, 5Strands Pet Food & Environmental Intolerance Test for $100. For this, you only need to send a fur sample in the mail to a lab; results were sent to my inbox within seven days. The report showed that both of my cats showed strong intolerances to common ingredients in their diet, like various types of fish and chicken meal. This sent me into a panic about the health and (dis)comfort of my cats.
After more research, I learned that hair/fur samples are not an accurate way to measure allergies and intolerances, and studies show kits claiming to provide these results perform no better than chance and often produce inconsistent or false results.
“There’s no scientific evidence to support allergy testing through hair, fur, or saliva,” says Richardson. “Veterinarian-supervised elimination diets to test for food allergy and intra-dermal skin testing or blood tests to test for environmental allergies remain the gold standard.”
So, save your money and consult a vet instead if you suspect your pet is suffering because of allergies or intolerances.
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Tech
‘The Last Airbender’ Leaked Online. Some Fans Say Paramount Deserves the Fallout
The online leak of a full version of Avatar: Aang, The Last Airbender—a highly anticipated animated film in a multimedia fantasy franchise—has divided passionate fans while upsetting those who spent years working on the film.
The leaks began on X late on Saturday night, about six months before Aang was scheduled to premiere on Paramount+. User @ImStillDissin posted two short clips from the film. “Nickelodeon accidentally emailed me the entire Avatar aang movie,” he claimed. He also threatened to stream the entire movie if Paramount didn’t release an official trailer, and he posted a still from the movie’s end credits, revealing previously undisclosed voice-over cast and roles. The media from @ImStillDissin’s posts were later hit with copyright strikes and removed.
But within 48 hours, links to download the full movie appeared on 4chan and X, where some users also directly streamed the film. Across the web, fans said they had successfully pirated and watched what appeared to be a nearly finished and “beautiful” animated film.
While some argued that Paramount deserved to be punished because of certain creative and marketing decisions around the movie, others noted what a blow the leak was to the animators and production crew. A number of those team members took to social media to convey their sadness and frustration.
“We worked on the aang movie for years with the expectation that’d [sic] we’d get to celebrate all of our hard work in theaters. Just to see people unceremoniously leak the film and pass our shots around on twitter like candy,” animator Julia Schoel wrote Tuesday on X.
The user behind @ImStillDissin, who would not reveal his real name due to fear of legal repercussions, tells WIRED that he obtained the movie almost by chance and did not expect his posts to set off such a crisis in the entertainment world. “When I posted those clips I was purely trolling,” he says. “I was expecting a day of clout farming at best, not for the whole thing to blow up like this.”
(While WIRED has done its due diligence in verifying that the person speaking to us was behind the @ImStillDissin X account, we acknowledge that the hacking community is known to troll.)
According to @ImStillDissin, a screen-grabbed version of Avatar: Aang, The Last Airbender was circulating among people he knew from his days in the hacking community, one of whom shared it with him. “Broadly speaking, the supply chain for movies and TV is rife with insecure companies and vendors and lax checks,” he claims. He notes that two different SpongeBob SquarePants movies leaked months before their release dates in 2024. “Someone on 4chan who wasn’t happy at me drip-feeding stuff posted a copy of a draft script [of the new Avatar film] from like two years back,” says @ImStillDissin.
Neither Nickelodeon nor its parent company Paramount have confirmed a hack had taken place, nor have they issued a statement on the matter. They also did not respond to requests for comment.
Originally announced in 2021, Avatar: Aang, The Last Airbender marked the first production for Avatar Studios, a division of Nickelodeon’s animation department.
Some people felt justified in pirating and sharing the movie due to the recasting of voice actors. Last year, during a Reddit AMA, casting director Jenny Jue wrote that the voice cast from the Avatar TV show that aired on Nickelodeon in the 2000s was not returning due to efforts to “match actors’ ethnic/racial background to the characters they’re portraying.”
Tech
NASA Wants to Put Nuclear Reactors on the Moon
Having demonstrated that it has the operational capability to transport humans safely to the moon and back, the United States is moving on to its next major aim: It wants nuclear reactors in orbit and on the lunar surface by 2030. For such a feat, the National Aeronautics and Space Administration will have to work in conjunction with the Department of Defense and the Department of Energy.
In a post on X, the White House Office of Science and Technology Policy (OSTP) unveiled a document with new guidelines for federal agencies to establish the space nuclear technology road map for the coming years. This, they say, will ensure “US space superiority.”
At present, space instruments use solar power to operate. However, this is considered impractical for more complex purposes. Although technically there is always sunlight, the power is intermittent and almost always requires bulky batteries to store it.
Reactors produce fairly continuous energy for years through nuclear fission. They can also be used for so-called nuclear electric propulsion. Continuous output makes them the most viable option for lunar base subsistence, but they can also allow spacecraft to undertake long or complex missions without worrying about depleting a limited supply of chemical fuel.
Nuclear technology, in short, makes it possible to go farther, with more payload, for longer, and with fewer constraints.
According to the memorandum, the US goal is to put a medium-power reactor in orbit by 2028, with a variant designed for nuclear electric propulsion, and a first functional large reactor on the surface of the moon by 2030. To achieve this, both NASA and the Pentagon will develop energy technologies in parallel, using the current strategy of competition among contractors.
The reactors will have to be modular and scalable, and will have to include applications for both future life on the moon and space propulsion. For its part, the DOE will have to ensure that these projects have the fuel, infrastructure, and safety features necessary to achieve their objectives. In addition, the agency will evaluate whether the industry has the capacity to produce up to four reactors in five years.
The plan contemplates technologies that produce at least 20 kilowatts of electricity (kWe) for three years in orbit and at least five years on the lunar surface. In the meantime, they should have a design capable of raising power to 100 kWe. The first designs should arrive within a year.
Finally, the order tasks the OSTP with creating a road map for the initiative, noting obstacles and recommendations for addressing them.
“Nuclear power in space will give us the sustained electricity, heating, and propulsion essential to a permanent presence on the moon, Mars, and beyond,” OSTP posted. For his part, NASA administrator Jared Isaacman posted, “The time has come for America to get underway on nuclear power in space.” The message was followed by an emoji of a US flag.
The plan provides a common framework for each agency to work within. In the background, the race for space infrastructure is evidence of technological competition with China, which is also seeking advanced energy capabilities for the moon.
This story originally appeared in WIRED en Español and has been translated from Spanish.
Tech
AI Could Democratize One of Tech’s Most Valuable Resources
Nvidia is the undisputed king of AI chips. But thanks to the AI it helped build, the champ could soon face growing competition.
Modern AI runs on Nvidia designs, a dynamic that has propelled the company to a market cap of well over $4 trillion. Each new generation of Nvidia chip allows companies to train more powerful AI models using hundreds or thousands of processors networked together inside vast data centers. One reason for Nvidia’s success is that it provides software to help program each new generation of chip. That may soon not be such a differentiated skill.
A startup called Wafer is training AI models to do one of the most difficult and important jobs in AI—optimizing code so that it runs as efficiently as possible on a particular silicon chip.
Emilio Andere, cofounder and CEO of Wafer, says the company performs reinforcement learning on open source models to teach them to write kernel code, or software that interacts directly with hardware in an operating system. Andere says Wafer also adds “agentic harnesses” to existing coding models like Anthropic’s Claude and OpenAI’s GPT to soup up their ability to write code that runs directly on chips.
Many prominent tech companies now have their own chips. Apple and others have for years used custom silicon to improve the performance and the efficiency of software running on laptops, tablets, and smartphones. At the other end of the scale, companies like Google and Amazon mint their own silicon to improve the performance of their cloud-computing platforms. Meta recently said it would deploy 1 gigawatt of compute capacity with a new chip developed with Broadcom. Deploying custom silicon also involves writing a lot of code so that it runs smoothly and efficiently on the new processor.
Wafer is working with companies including AMD and Amazon to help optimize software to run efficiently on their hardware. The startup has so far raised $4 million in seed funding from Google’s Jeff Dean, Wojciech Zaremba of OpenAI, and others.
Andere believes that his company’s AI-led approach has the potential to challenge Nvidia’s dominance. A number of high-end chips now offer similar raw floating point performance—a key industry benchmark of a chip’s ability to perform simple calculations—to Nvidia’s best silicon.
“The best AMD hardware, the best [Amazon] Trainium hardware, the best [Google] TPUs, give you the same theoretical flops to Nvidia GPUs,” Andere told me recently. “We want to maximize intelligence per watt.”
Performance engineers with the skill needed to optimize code to run reliably and efficiently on these chips are expensive and in high demand, Andere says, while Nvidia’s software ecosystem makes it easier to write and maintain code for its chips. That makes it hard for even the biggest tech companies to go it alone.
When Anthropic partnered with Amazon to build its AI models on Trainium, for instance, it had to rewrite its model’s code from scratch to make it run as efficiently as possible on the hardware, Andere says.
Of course, Anthropic’s Claude is now one of many AI models that are now superhuman at writing code. So Andere reckons it may not be long before AI starts consuming Nvidia software advantage.
“The moat lives in the programmability of the chip,” Andere says in reference to the libraries and software tools that make it easier to optimize code for Nvidia hardware. “I think it’s time to start rethinking whether that’s actually a strong moat.”
Besides making it easier to optimize code for different silicon, AI may soon make it easier to design chips themselves. Ricursive Intelligence, a startup founded by two ex-Google engineers, Azalia Mirhoseini and Anna Goldie, is developing new ways to design computer chips with artificial intelligence. If its technology takes off, a lot more companies could branch into chip design, creating custom silicon that runs their software more efficiently.
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