Tech
Now You Can Get Your Flu Vaccine at Home
Instead of going to the pharmacy to get the annual flu vaccine, many people in the US will now be able to get it shipped to their door to take at home themselves.
Starting today, AstraZeneca’s FluMist is available through an online pharmacy in 34 states. FluMist is not a new vaccine. It was originally approved by the Food and Drug Administration in 2003 and previously could only be administered by a health care professional. But last September, the FDA said the vaccine could be self-administered.
It’s AstraZeneca’s first foray into direct-to-consumer medicine—a trend being spearheaded by Novo Nordisk and Eli Lilly to sell their popular GLP-1 drugs for diabetes and weight management to patients.
“We recognized that people’s daily lives are busier than ever, and we knew we needed to meet people where they are facing the realities of real life,” said Tonya Villafana, vice president of medical and scientific affairs at AstraZeneca, at a press conference on Thursday. “FluMist Home is designed to remove traditional obstacles to vaccination, things like scheduling clinic visits, waiting in line, and the fear of needles.”
AstraZeneca is hoping that an at-home offering will help boost flu vaccination rates. Only about 47 percent of adults get vaccinated against flu, according to the Centers for Disease Control and Prevention. Among children, flu vaccination rates are dropping along with those of other routine childhood vaccines. As of April 26 this year, 49.2 percent of children received a flu vaccination—lower than 53.4 percent at the same time the previous season, per the CDC.
“Getting vaccinated each year is the best way to prevent influenza, which causes illness in a substantial proportion of the US population every year and may result in serious complications, including hospitalization and death,” said Peter Marks, former director of the FDA’s Center for Biologics Evaluation and Research, in a statement last year on FluMist’s approval for self-administration.
The CDC classified the 2024-2025 flu season as high severity across all age groups in the US, resulting in at least 610,000 hospitalizations and 27,000 deaths. It was the most severe flu season since the 2009 H1N1 swine flu pandemic.
AstraZeneca’s September 2024 approval was based on a study with vaccine recipients and caregivers to evaluate whether the instructions for use were appropriately designed so that they could safely and effectively use the vaccine.
The vaccine contains a weakened form of the live influenza virus and protects against four types of flu strains. It is approved for ages 2 through 49. For those under 18, it must be administered by a caregiver.
To order, customers will need to complete a medical screening questionnaire. A licensed health care provider will review each submission to determine eligibility. Once eligibility is confirmed and insurance is verified, the vaccine will be prescribed and shipped directly to the purchaser’s home on a date they select. FluMist is covered by most insurance plans, but consumers will need to pay an $8.99 delivery fee.
AstraZeneca says FluMist is not yet available in all states due to local pharmacy laws, but the company aims to be able to provide the at-home spray to all the contiguous states in the future. The vaccine will continue to be available in doctors’ offices and pharmacies for administration by health care professionals across the country.
Tech
Join Our Livestream: Musk v. Altman and the Future of OpenAI
Two of Big Tech’s most influential billionaires, Sam Altman and Elon Musk, will go head-to-head in a highly anticipated trial beginning April 27. In Musk v. Altman, a judge, advised by a jury, will ultimately determine whether OpenAI has strayed from its founding mission to ensure that artificial general intelligence (AGI) benefits humanity, and the ruling could influence how the world’s leading AI developer controls and distributes its technology. For now, you can learn more about the trial here.
On the Panel
On May 8, a panel of WIRED experts will go live to answer your questions about this consequential case.
- Zoë Schiffer: WIRED’s director of business and industry, who oversees coverage of business and Silicon Valley.
- Maxwell Zeff: a senior writer at WIRED covering the business of artificial intelligence. He writes the weekly Model Behavior newsletter, which focuses on the people, communities, and companies behind Silicon Valley’s AI scene.
- Paresh Dave: a senior writer at WIRED covering the inner workings of Big Tech companies. He writes about how apps and gadgets are built and about their impacts while giving voice to the stories of the underappreciated and disadvantaged.
Ask a Question
Submit all your burning questions about this historic legal battle at WIRED’s next, subscriber-only livestream scheduled for May 8 at noon ET / 9 PT. To leave questions in advance as the trial unfolds, head to the comment section below.
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In the meantime, check out past livestreams on Big Tech and the military, the future of electric vehicles, and more.
Tech
Blackbox replaces two racks of HPE storage with 8U of Everpure | Computer Weekly
Service provider Blackbox Hosting has consolidated storage from two full racks down to just 8U of rack space following migration to Everpure FlashArray hardware. The move has allowed the provider to deliver “sovereign” cloud services with a 10:1 data reduction ratio and an 85% reduction in power utilisation.
Blackbox Hosting evolved over 14 years from a single rack to supporting more than 1,500 virtual machines (VMs), and has datacentre capacity at Canary Wharf with a secondary site in Slough.
The company operates a fully managed, sovereign (see box) model for major software suppliers including Iris Software Group, which supports payroll and financial management for approximately 60% of UK academies.
Blackbox previously relied on HPE 3PAR 8400 all-flash arrays. However, as the hardware approached end-of-life, the company faced mounting challenges.
“Support renewal costs were significant, and we had issues with HPE support,” said Matthew Burden, CEO at Blackbox Hosting. “We had a power supply failure in a DR site, and despite a four-hour SLA [service-level agreement], it took nearly two weeks to replace. They also began charging for firmware updates that were previously included.”
The 3PAR environment was cumbersome, said Burden, and required two full racks of hardware to manage the company’s near-petabyte scale.
When it looked for a more performant and dense alternative, Blackbox turned to Pure Storage, which recently rebranded as Everpure.
High density; ‘one-second’ RPO
Blackbox has deployed a range of Pure Storage FlashArray models across its two datacentres to support its active-passive high-availability design.
The deployment includes two FlashArray//X50 R3s, two X50 R4s, and two FlashArray//C20 units for file clusters.
The hardware supports predominantly Hyper-V and VMware VMs, running 90% Windows-based workloads, primarily SQL Server, plus Linux servers.
The transition from 3PAR to Pure has seen a dramatic consolidation of physical space. “We went from two entire racks filled with disks to two 4U boxes,” said Burden. “Our total provisioned storage is 998TB and we get a total reduction of 10:1. 3PAR had deduplication, but not compression on SSDs.”
Beyond space savings, the disaster recovery (DR) capabilities have seen a massive upgrade. Previously, the company’s recovery point objective (RPO) was limited to 15 minutes. “With Pure Storage, it is one second,” said Durden. “We replicate all 1,500 VMs to our backup datacentre. For a customer with 1,000 VMs, we can spin those up for quarterly testing and they are only one second out from live data.”
Performance and sustainability
The shift to non-volatile memory express-based flash has also provided a significant boost to the provider’s green credentials. Sustainability reports generated via Pure’s Evergreen dashboard show an 85% saving in power utilisation compared with the legacy HPE environment.
For the end users – which include major corporate energy, finance and transport organisations – the benefit is felt in application speed. “We’ve had clients with huge databases that were always slow with previous providers,” said Justin Field, commercial director at Blackbox. “They can pull data significantly faster now, which is a big play for us when competing against hyperscalers.”
Burden also highlighted the “zero-touch” operational simplicity of the new arrays. “The older arrays were very cumbersome; you had to know exactly what you were doing,” he said. “The Pure web interface is very simple, which makes the operational side much easier. Plus, with Evergreen, we don’t have to pull arrays out for upgrades. We can just put in new controllers as scale increases.”
Tech
Tackling the housing shortage with robotic microfactories
A national housing shortage is straining finances and communities across the United States. In Massachusetts, at least 222,000 homes will have to be built in the next 10 years to meet the population’s needs. At the same time, there are numerous challenges in traditional construction. There’s a shortage of skilled construction workers. Most projects involve multiple contractors and subcontractors, adding complexity and lag time. And the construction process, as well as the buildings themselves, can be a major source of emissions that contribute to climate change.
Reframe Systems, co-founded by Vikas Enti SM ’20, uses robotics, software, and high-performance materials to address these problems. Founded in 2022, the company deploys microfactories that bring housing fabrication and production closer to the regions where the homes are needed. The first homes designed and manufactured in Reframe’s first microfactory have been fully built in Arlington and Somerville, Massachusetts.
Enti’s experiences in MIT System Design and Management (SDM) shaped the company from its start. “Learning how to navigate the system and finding the optimal value for each stakeholder has been a key part of the business strategy,” he says, “and that’s rooted in what I learned at SDM.”
Better tools for system-level problems
Enti applied to SDM’s master of science in engineering and management while he was working at Kiva Systems, overseeing its acquisition by Amazon and transformation into Amazon Robotics. He found that the SDM program’s fundamentals of systems engineering, system architecture, and project management provided him with the tools he needed to address system-level problems in his work.
While he was at MIT, Enti also served as an associate director for the MIT $100K Entrepreneurship Competition, which offers students and researchers mentorship, feedback, and potential funding for their startup ideas. He realized that “there isn’t a single formula for how businesses start, or how long it takes to get them started,” he says, which helped shape his plans to start his own business.
Enti took a leave of absence from MIT to oversee the expansion of Amazon Robotics in Europe. He returned and completed his degree in 2020, writing his thesis on developing technology that could mitigate falls for elderly people. This instinct to use his education for a good cause resurfaced when his daughters were born. He wanted his future business to address a real-world problem and have a social impact, while also reducing carbon emissions.
Growing housing, shrinking emissions
Enti concluded that housing, with immediate real-world impact and a significant share of global carbon emissions, was the right problem to work on. He reached out to his colleagues Aaron Small and Felipe Polido from Amazon Robotics to share his idea for advanced, low-cost factories that could be deployed quickly and close to where they were needed. The two joined him as co-founders.
Currently, the microfactory in Andover, Massachusetts, produces structural panels, with robotics completing wall and ceiling framing and people completing the rest of the work, including wiring and plumbing. Eventually, Reframe hopes to automate more of the building process through further use of robotics. The modular construction process allows for reduced waste and disruption on the eventual home site. And the finished homes are designed to be energy-efficient and ready for solar panel installation. The company is set to start work soon on a group of homes in Devens, Massachusetts.
In addition to the Andover location, Reframe is setting up in southern California to help rebuild homes that were destroyed in the area’s January 2025 wildfires. The company’s software-assisted design process and the adjustability of the microfactories allows them to meet local zoning and building codes and align with the local architectural aesthetic. This means that in Somerville, Reframe’s completed buildings look like modernized versions of the neighboring three-story buildings, known locally as “triple-deckers.” On the other side of the country, Reframe’s design offerings include Spanish-style and craftsman homes.
“Housing is a complex systems problem,” Enti says, explaining the impact SDM has had on his work at Reframe. The methods and tools taught in the integrated core class EM.412 (Foundations of System Design and Management) help him tackle systems-level problems and take the needs of multiple stakeholders into account. The Reframe team used technology roadmapping as they devised their overall business plan, inspired by the work of Olivier de Weck, associate head of the MIT Department of Aeronautics and Astronautics. And lectures on project management from Bryan Moser, SDM’s academic director, remain relevant.
“Embracing the fact that this is a systems problem, and learning how to navigate the system and the stakeholders to make sure we’re finding the optimal value, has been a key part of the business strategy,” Enti says.
Reframe Systems is set to continue learning through iteration as they plan to expand their network of microfactories. The company remains committed to the core vision of sustainably meeting the country’s need for more housing. “I’m grateful we get to do this,” Enti says. “Once you strip away all the robotics, the advanced algorithms, and the factories, these are high-quality, healthy homes that families get to live in and grow.”
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