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Crispr Offers New Hope for Treating Diabetes

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Crispr Offers New Hope for Treating Diabetes


Crispr gene-editing technology has demonstrated its revolutionary potential in recent years: It has been used to treat rare diseases, to adapt crops to withstand the extremes of climate change, or even to change the color of a spider’s web. But the greatest hope is that this technology will help find a cure for a global disease, such as diabetes. A new study points in that direction.

For the first time, researchers succeeded in implanting Crispr-edited pancreatic cells in a man with type 1 diabetes, an autoimmune disease where the immune system attacks insulin-producing cells in the pancreas. Without insulin, the body is then unable to regulate blood sugar. If steps aren’t taken to manage glucose levels by other means (typically, by injecting insulin), this can lead to damage to the nerves and organs—particularly the heart, kidneys, and eyes. Roughly 9.5 million people worldwide have type 1 diabetes.

In this experiment, edited cells produced insulin for months after being implanted, without the need for the recipient to take any immunosuppressive drugs to stop their body attacking the cells. The Crispr technology allowed the researchers to endow the genetically modified cells with camouflage to evade detection.

The study, published last month in The New England Journal of Medicine, details the step-by-step procedure. First, pancreatic islet cells were taken from a deceased donor without diabetes, and then altered with the gene-editing technique Crispr-Cas12b to allow them to evade the immune response of the diabetes patient. Cells altered like this are said to be “hypoimmune,” explains Sonja Schrepfer, a professor at Cedars-Sinai Medical Center in California and the scientific cofounder of Sana Biotechnology, the company that developed this treatment.

The edited cells were then implanted into the forearm muscle of the patient, and after 12 weeks, no signs of rejection were detected. (A subsequent report from Sana Biotechnology notes that the implanted cells were still evading the patient’s immune system after six months.)

Tests run as part of the study recorded that the cells were functional: The implanted cells secreted insulin in response to glucose levels, representing a key step toward controlling diabetes without the need for insulin injections. Four adverse events were recorded during follow-ups with the patient, but none of them were serious or directly linked to the modified cells.

The researchers’ ultimate goal is to apply immune-camouflaging gene edits to stem cells—which have the ability to reproduce and differentiate themselves into other cell types inside the body—and then to direct their development into insulin-secreting islet cells. “The advantage of engineering hypoimmune stem cells is that when these stem cells proliferate and create new cells, the new cells are also hypoimmune,” Schrepfer explained in a Cedars-Sinai Q+A earlier this year.

Traditionally, transplanting foreign cells into a patient has required suppressing the patient’s immune system to avoid them being rejected. This carries significant risks: infections, toxicity, and long-term complications. “Seeing patients die from rejection or severe complications from immunosuppression was frustrating to me, and I decided to focus my career on developing strategies to overcome immune rejection without immunosuppressive drugs,” Schrepfer told Cedars-Sinai.

Although the research marks a milestone in the search for treatments of type 1 diabetes, it’s important to note that the study involved one one participant, who received a low dose of cells for a short period—not enough for the patient to no longer need to control their blood sugar with injected insulin. An editorial by the journal Nature also says that some independent research groups have failed in their efforts to confirm that Sana’s method provides edited cells with the ability to evade the immune system.

Sana will be looking to conduct more clinical trials starting next year. Without overlooking the criticisms and limitations of the current study, the possibility of transplanting cells modified to be invisible to the immune system opens up a very promising horizon in regenerative medicine.

This story originally appeared on WIRED en Español and has been translated from Spanish.



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Save Up to 40% With These Acer Promo Codes and Discounts

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Save Up to 40% With These Acer Promo Codes and Discounts


Acer is one of the top largest PC manufacturers in the world, perhaps best known for its gaming line and budget-friendly options. If you’ve already got your eye on an Acer product like a laptop or monitor, and are shopping at the company’s online storefront, you should be using one of these Acer promo codes and coupons to save some cash on your purchase.

Save 40% on Accessories When You Build an Acer Bundle

If you’re buying from Acer, you’re most likely shopping for either a desktop PC or laptop. With this discount, you can get a really solid deal on accessories if you bundle it with a mouse, laptop bag, or headset. When you go to purchase a PC, just click “Build Bundle” and you’ll see some of the eligible options, all of which are reduced by 40%. The Nitro Mechanical Keyboard, for example, goes from $50 to just $30. That 40% is a real discount, too, as that same keyboard costs $50 on Amazon when I checked.

Beyond peripheral add-ons, you can also save 10% off Acer Care Plus extended service plans or McAfee LiveSafe antivirus subscriptions. You can bundle up to five products together to save the most money. If you’re headed off to college (or have a kid in the family), a bundle like this can get you everything you need for a gaming or studying setup on the go.

Shop Rotating Weekly Deals on Monitors and Gaming Gear

Acer’s PC gaming offerings come in either the flagship Predator brand or the budget-tier Nitro. Acer offers rotating weekly deals on everything from monitors to gaming laptops, some of which are my favorites that I’ve tested in their given category. The Acer Nitro V 16, for example, was a budget gaming laptop that I recommended quite a lot last year because of its incredible price. The one I tested was the entry-level version with an Nvidia RTX 5050 inside, but Acer has the RTX 5060 model in its own storefront. It’s $100 off right now at $1,200, which comes with 16 GB of RAM and a terabyte of storage. In fact, it’s only $30 more than the RTX 5050 model, despite offering a significant jump in gaming performance. These discounts are reflected right on the product pages, so there’s no promo code, discount code, or coupon code required.

Acer has a wide selection of monitors available, too, whether that’s a massive 49-incher or a more modest 27-inch gaming workhorse. One of my favorite discounts I saw right now was the Acer Nitro XV2, a 27-inch 1440p display with a 300 Hz refresh rate. It’s 44% off at the time of writing, bringing the price down to just $250. Because these discounts are swapped out on a weekly basis, it’s worth checking back to see if the product you’re eyeing has a new discount.

Select Customers Can Get 15% Off Their Purchase

Acer also offers a number of added discounts at checkout, including 15% off for students. Students will need to verify through Student Beans or SheerID. Because a lot of the devices Acer offers are budget-friendly, they can be attractive for students, and the extra 15% off is the icing on the cake.

We tested the Acer Swift 16 AI last year and really enjoyed the high-resolution, OLED screen and impressively quiet performance. Acer has the smaller version of this same laptop available, the Swift 14 AI, which is currently $150 off. You also might check out the Acer Chromebook Plus 514, a laptop we liked quite a bit when we reviewed it in 2024.

Acer offers this same 15% discount for active duty military, veterans, and their families. It also applies to healthcare professionals, which can be verified through its healthcare discount portal.



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AI Research Is Getting Harder to Separate From Geopolitics

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AI Research Is Getting Harder to Separate From Geopolitics


The world’s top AI research conference, the Conference on Neural Information Processing Systems—better known as NeurIPS—became the latest organization this week to become embroiled in a growing clash between geopolitics and global scientific collaboration. The conference’s organizers announced and then quickly reversed controversial new restrictions for international participants after Chinese AI researchers threatened to boycott the event.

“This is a potential watershed moment,” says Paul Triolo, a partner at the advisory firm DGA-Albright Stonebridge who studies US-China relations. Triolo argues that attracting Chinese researchers to NeurIPS is beneficial to US interests, but some American officials have pushed for American and Chinese scientists to decouple their work—especially in AI, which has become a particularly sensitive topic in Washington.

The incident could deepen political tensions around AI research, as well as dissuade Chinese scientists from working at US universities and tech companies in the future. “At some level now it is going to be hard to keep basic AI research out of the [political] picture,” Triolo says.

In its annual handbook for paper submissions, issued in mid-March, NeurIPS organizers announced updated restrictions for participation. The rules stated that the event could not provide services including “peer review, editing, and publishing” to any organizations subject to US sanctions, and linked to a database of sanctioned entities. It included companies and organizations on the Bureau of Industry and Security’s entity list and those on another list with alleged ties to the Chinese military.

The new rules would have affected researchers at Chinese companies like Tencent and Huawei who regularly present work at NeurIPS. The database also includes entities from other countries such as Russia and Iran. The US places limits on doing business with these organizations, but there are no rules around academic publishing or conference participation.

The NeurIPS handbook has since been updated to specify that the restrictions apply only to Specially Designated Nationals and Blocked Persons, a list used primarily for terrorist groups and criminal organizations.

“In preparing the NeurIPS 2026 handbook, we included a link to a US government sanctions tool that covers a significantly broader set of restrictions than those NeurIPS is actually required to follow,” the event’s organizers said in a statement issued Friday. “This error was due to miscommunication between the NeurIPS Foundation and our legal team.”

Before they reversed course, the conference organizers initially said that the new rule was “about legal requirements that apply to the NeurIPS Foundation, which is responsible for complying with sanctions,” adding that it was seeking legal consultation on the issue.

Immediate Backlash

The new rule drew swift backlash from AI researchers around the world, particularly in China, which produces a large quantity of cutting-edge machine learning papers and is home to a growing share of the world’s top AI talent. Several academic groups there issued statements condemning the measure and, more importantly, discouraging Chinese academics from attending NeurIPS in the future. Some urged Chinese academics to contribute instead to domestic research conferences, potentially helping increase the country’s influence in relevant science and tech fields.

The China Association of Science and Technology (CAST), an influential government-affiliated organization for scientists and engineers, said Thursday that it would stop providing funding for Chinese scholars traveling to attend NeurIPS and would use the money instead to support domestic and international conferences that “respect the rights of Chinese scholars.”

CAST also said it will no longer count publications at the 2026 NeurIPS conference as academic achievements when evaluating future research funding. It’s unclear if the organization will reverse course now that NeurIPS has walked back the new rule.



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Iranian Hackers Breached Kash Patel’s Email—but Not the FBI’s

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Iranian Hackers Breached Kash Patel’s Email—but Not the FBI’s


Handala’s second claim, however—that it hacked the FBI—seems, for now, to be fiction. All evidence points to Handala having breached Patel’s older, personal Gmail account. Widely believed to be a “hacktivist” front for Iran’s intelligence agency the MOIS, Handala suggested on its website that the emails contained classified information, but the messages initially reviewed by WIRED didn’t appear to be related to any government work. TechCrunch did find, however, that Patel appears to have forwarded some emails from his Justice Department email account to his Gmail account in 2014.

Handala, which cybersecurity experts have described to WIRED as an “opportunistic” hacker group whose cyberattacks and breaches are often calculated more for their propaganda value than their tactical impacts, has nonetheless made the most of Patel’s embarrassing breach. “To the whole world, we declare: the FBI is just a name, and behind this name, there is no real security,” the group wrote in its statement. “If your director can be compromised this easily, what do you expect from your lower-level employees?”

Handala Hackers Put $50 Million Bounty on Trump and Netanyahu’s Heads

For further evidence of Handala’s bombastic rhetoric, look no further than another post on its website earlier this week (we’re intentionally not linking to it) that offered a $50 million bounty to anyone who could “eliminate” US president Donald Trump and Israeli prime minister Benjamin Netanyahu. “This substantial prize will be awarded, directly and securely, to any individual or group bold enough to show true action against tyranny,” the hackers’ statement read, along with an invitation to any would-be assassins to reach out via the encrypted messaging app Session. “All our communication and payment channels utilize the latest encryption and anonymization technologies, your safety and confidentiality are fully guaranteed.”

That bounty, Handala explained, was posted in answer to a statement about Handala published on the US Department of Justice website last week that offered $10 million for information leading to the identity or location of anyone who carries out “malicious cyber activities against US critical infrastructure” on behalf of a foreign government.

“Our message is clear: If you truly have the will and the power, come and find us!” Handala wrote in its response. “We fear no challenge and are prepared to respond to every attack with even greater force.”

In yet another post on its website this week, Handala also claimed to have doxed 28 engineers at military contractor Lockheed Martin working in Israel and threatened them with personal harm if they didn’t leave the country within 48 hours. When WIRED tried calling the phone numbers included in Handala’s leaked data, however, most of them didn’t work.

Apple says no device with its Lockdown Mode security feature enabled has ever been successfully compromised by mercenary spyware in the nearly four years since its launch. Amnesty International’s security lab head, Donncha Ó Cearbhaill, also says his team has seen no evidence of a successful attack against a Lockdown Mode–enabled iPhone. And Citizen Lab, which has documented several successful spyware attacks against iPhones, says none involve a Lockdown Mode bypass, while in two cases its researchers found the feature actively blocked attacks against NSO Group’s Pegasus and Intellexa’s Predator. Google researchers, meanwhile, found one spyware strain that simply abandons infection attempts when it detects the feature is enabled.

Lockdown Mode works by disabling commonly exploited iPhone features, such as most message attachment types and features like links and link previews. Incoming FaceTime calls are blocked unless the user has previously called that person within the past 30 days. When the iPhone is locked, it blocks connections with computers and accessories. The device will not automatically join nonsecure Wi-Fi networks, and 2G and 3G support is disabled. Apple has also doubled bounties for researchers who detect any Lockdown Mode bypass, with payouts up to $2 million.



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