Connect with us

Tech

I Tried the Best At-Home Pet DNA Test Kits on My Two Cats

Published

on

I Tried the Best At-Home Pet DNA Test Kits on My Two Cats


If You Have a Dog, Consider These Kits

I don’t have a dog, so I didn’t try these at-home DNA test kits for dogs, but these are the kits specifically for dogs from Basepaws and Wisdom Panel, the two companies I’ve tested for my cats.

Wisdom Panel

Breed Discovery Dog DNA Kit

Wisdom Panel

Premium Dog DNA Kit

Wisdom Panel

Essential Dog DNA Kit

How Does a DNA Testing Kit Work?

Pet DNA tests rely on pet owners collecting cells for testing through a cheek swab, where the sample is put into a sealed stabilizing or preserving fluid for transit. You’ll mail the sample back to the lab in the prepaid envelope. It takes up to five weeks to get results. (The first time I sent my cat Basil’s Basepaws sample, the company emailed that the results were inconclusive, and I had to wait for another kit to be sent, re-swab him, and wait another five weeks for results.)

At the lab, the sample is analyzed against the company’s breed and genetic health database. They use single nucleotide polymorphism (SNP) arrays—the standard technology used to identify breed ancestry—as well as various inherited traits and risk of common diseases. Essentially, different breeds have distinct patterns of SNPs in their genomes, which act as the genetic markers. These tests analyze the pet’s DNA sample for specific SNPs and then compare them to the company’s existing database to estimate the composition of breed types in the animal. This not only tells you about breed composition, but can also identify the specific DNA sequences that are markers for potential health risks, like predispositions to diseases or hereditary cancers.

Don’t take the health or DNA test results as absolute truth, however. “This can lead to a false sense of security or false alarms,” says veterinarian Amanda Chambers. Forward your results to your veterinarian and always follow up with scheduling a visit to the vet if your pet is marked as a carrier for any genetic disease.

Limitations of At-Home DNA Test Kits

After chatting with Jamie Richardson, head of veterinary medicine at Small Door Veterinary, I’ve found that these are the major areas of limitations with at-home DNA test kits:

  • Results depend on the size/diversity of the genetic database
  • Most kits test known markers only—not full genomes
  • Feline data is less developed
  • Misinterpretation of results can lead to unnecessary concern

How Accurate Is At-Home DNA Testing?

Wisdom Panel claims its breed results for cats are over 98 percent accurate and that tests for dogs are over 99 percent accurate.

I’ve outlined the results below, so you can see the disparity in results from the two kits I tested, particularly with breed ancestry.

One problem with the vast disparity in results is that the two companies have different sample sizes and metrics for identifying breeds. But the biggest issue for cat owners taking these at-home DNA tests is that you can’t really identify most cats’ breeds the way you can with dogs. Unless your cat is a purebred, around 95 percent of cats don’t belong to a recognized breed. Cats’ genetic backgrounds are muddied—they’re just similar mixes with different physical characteristics, so the tests only show the breed(s) they share the most markers with. Basically, these tests for cats aren’t able to reliably tell us about breed composition, just similarity to other breeds’ traits in the company’s data pool.

From my research, it seems the breed identification part of these tests is more accurate for dogs, as dog DNA is so much more diversified. Breeds have been clearly defined after centuries of diversifying from other breeds, and dog DNA mutates quickly, with genes changing quickly after just a few generations. Cats are not much different from their Egyptian ancestors.

Interestingly, in this report from CBS in 2023, the news organization sent dog and human DNA to different at-home test companies and got various results, ranging from 65 to only 29 percent German shepherd DNA for the dog. The human DNA results were attributed to a bulldog, border collie, and cane corso mix.

TL;DR

There isn’t one catch-all way to determine a pet’s genetic makeup or ancestry. Humans like categories. And breeds are essentially human constructs, based on the way the dog or cat looks. The genetic part of the test is fun, but take it with a grain of salt—especially with cats.

Ancestry Results

If you read above, you know that there’s a significant disparity in results based on the pool the sample is compared against.

For example, below are the results I got for my cat Clover, who’s a dilute calico with long, white fur and visually looks most like a Maine coon or Norwegian forest cat.

(I also tested my run-of-the-mill gray cat Basil, but he was almost entirely “American domestic cat” and “polycat/domestic shorthair”—basically the mutt final boss, a result of many generations of mixed breeding between different types of cats, where ancestry and origin is almost impossible to determine.)

Health Results

Wisdom Panel tests for 49 genetic health predispositions by comparing the pet’s DNA against a panel of cat or dog genetic health checks. It tests for the top five genetic conditions that could impact the pet’s vet visits—essentially, the most common conditions that are seen in cats or dogs with a similar breed makeup as your pet. These are for things like drug sensitivity, immune deficiency, and bleeding disorders. They also identified the cat’s blood type (both of my cats were A) and transfusion risk (both were moderate).

Basepaws tests for up to 115 health markers, but my cat received results for only 44 genetic diseases (owners are encouraged to check results often in case missing markers are added as more data becomes available). This list felt more in-depth than the Wisdom Panel test, testing genes for markers against disorders in musculoskeletal and connective tissue; eyes; metabolic, autoimmune, and endocrine systems; blood; and more. Both of my cats, Clover and Basil, were cleared as having none of the genes that mark them as potential carriers of genetic diseases. It also identified blood type and transfusion risk, which were A and moderate (the same results I got with Wisdom Panel’s test).

If your pet gets flagged for any of these results, don’t panic. “The presence of a certain gene does not always mean a patient will develop a certain disorder that is associated with that gene—it just means they’re at higher risk of it. I would encourage owners to reach out to their veterinarian if they have questions after receiving the results of a DNA test,” says Chambers.

Oral Health Results

Wisdom Panel doesn’t screen for oral health, which is a huge problem in many pets, and can lead to tooth extraction and bigger health issues.

Oral health was a concern for me, and Basepaws tests for oral health by testing against an oral microbiome database. In this regard, Basepaws wins out.

According to the Basepaws results, Clover was a low risk for periodontal disease and tooth resorption, but at a high risk of halitosis. The report said bad breath could be indicative of a larger health issue, but she was cleared for disease, so I wasn’t sure what to do with that information.

Image may contain Page and Text

Courtesy of Molly Higgins

My other cat, Basil, was at high risk for all the dental markers mentioned above, and Basepaws came up with a health plan for him: “adopt a daily oral healthcare routine, consider supplementing Basil’s routine with products accepted by the Veterinary Oral Health Council, and schedule an appointment with your veterinarian in the next month.”

Image may contain Page and Text

Courtesy of Molly Higgins

Although I was alarmed at the results, I liked that Basepaws gave me recommended next steps so I could come up with a plan of action for care. And it’s important to remember that these results don’t necessarily mean a pet is guaranteed to develop the disease.

“These can be a helpful flag for your veterinarian to keep an eye on […] but does not necessarily mean aggressive testing is needed at that moment,” says Richardson. “DNA tests are tools to support—not replace—veterinary care.”

Traits Results

Both of the tests had this section, which tests for coat color traits and variants, but I found it mostly useless. Wisdom Panel’s assertions of both cats’ physical traits were correct. But with Basepaws, Clover, a dilute calico, was marked as being likely black in color.

I can see with my eyes what my cat(s) look like, but if you’re a genetic nerd, this might be fun to see what the actual DNA reflects.

A Note on At-Home Allergy Testing Kits

I recently tested both of my cats for their allergies and intolerances using a similar at-home test kit, 5Strands Pet Food & Environmental Intolerance Test for $100. For this, you only need to send a fur sample in the mail to a lab; results were sent to my inbox within seven days. The report showed that both of my cats showed strong intolerances to common ingredients in their diet, like various types of fish and chicken meal. This sent me into a panic about the health and (dis)comfort of my cats.

After more research, I learned that hair/fur samples are not an accurate way to measure allergies and intolerances, and studies show kits claiming to provide these results perform no better than chance and often produce inconsistent or false results.

“There’s no scientific evidence to support allergy testing through hair, fur, or saliva,” says Richardson. “Veterinarian-supervised elimination diets to test for food allergy and intra-dermal skin testing or blood tests to test for environmental allergies remain the gold standard.”

So, save your money and consult a vet instead if you suspect your pet is suffering because of allergies or intolerances.

Compare Our Top Picks

Image may contain Animal Cat Mammal Pet Abyssinian Couch Furniture and Text

Meet the Experts

Power up with unlimited access to WIRED. Get best-in-class reporting and exclusive subscriber content that’s too important to ignore. Subscribe Today.



Source link

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Tech

Your Cat Probably Isn’t Drinking Enough Water. A Fountain Can Help.

Published

on

Your Cat Probably Isn’t Drinking Enough Water. A Fountain Can Help.


Compare Our Picks

Others We Tested

Courtesy of Petkik

Petkit Eversweet Max for $90: This techy automatic fountain can be either cordless or battery-powered (lasting up to 83 days), and the drinking bowl is made of stainless steel, but the reservoir is plastic. Because of the shape of the basin with the chunky battery and reservoir bowl, it’s a little awkward to clean. The app logs every time a pet drinks and compares it over time to determine whether your cat’s drinking habits have changed. The app also keeps track of when the filter needs replacing and when you last added water. However, it doesn’t monitor or show you how much water is left in the basin; you have to check manually. The design also made it a bit difficult to clean and refill easily.

Enabot Rola Smart Pet Water Fountain for $50: This automatic fountain is cordless and runs on a rechargeable battery that lasts up to 60 days (although it can stay plugged in too). It has a wireless pump that uses magnetic induction—this pump was one of the easiest and most hassle-free to clean of all I tested. The fountain has a stainless steel top that holds a decent amount of water even when not running. Although the tank is plastic, and I’m wary of plastic now because of its propensity to harbor bacteria (plus it doesn’t keep water as cold). The app gives reminders of when the water’s low, the fountain needs cleaning, or the filter needs replacing, plus it automatically stops dispensing water and sends you a reminder to refill via app. It also logs the number of times your pet drank and for how long, monitoring hydration patterns over time and comparing the stats to average time used. A complaint I had is that this fountain wouldn’t stay on Continuous stream mode, even when plugged in, instead automatically switching to the Sensing stream.

Homerunpet Wireless Pet Fountain for $60: This cordless fountain can be used as a traditional fountain plugged in on its base, or can be detached and moved around the house with 30 days of battery life. I don’t love that this fountain is all plastic, but it’s easy to see water levels from the outside, the top and filter layers are super easy to remove, clean, and replace, and the wireless (basically silent) pump makes it a whole lot easier to clean. Plastic doesn’t keep the water as cold or clean as stainless steel, so you’ll have to clean it a lot more often. The fountain only begins bubbling when a cat (or human) approaches to save battery power, and there’s no option to control the flow (and no connected app). I like the wireless pump, but I’m really over plastic at this point.

Wonder Creature Cat Fountain a cyclindrical shaped device with a metal pan top that has a flower which water pours from...

Photograph: Kat Merck

Wonder Creature Cat Fountain for $20: My two cats have cycled through several water fountains over the past few years, but this no-nonsense version has been a stalwart. The inside is lit by a blue LED (bright enough to glow in the dark), and a clear viewing window on the side makes it easy to monitor the water level from afar. I also like the dishwasher-safe metal bowl and the fact you can remove parts of the yellow and white “flower” to create a fountain configuration your cat likes (waterfall, low bubble-up, tall bubble-up). The only major downsides are the fact it requires very frequent cleaning and filter changes due to the plastic body, and that there is no reservoir to hold water in case of power outage or pump malfunction. When I go on vacation I have to swap it out for an old-school gravity dispenser. Kat Merck

Happy & Polly Gothic Cat Drinking Fountain for $60: If you prefer gothic decor to neutral blandness, this ghostly ceramic cat fountain from Happy & Polly may tempt you to bite. The water bubbles up out of the top of the ghost and pools on the ceramic top. It’s fairly quiet at around 35 decibels, but it gets loud when the water is running low, and I worry about the motor burning out, as the 1.5-liter capacity can run dry fast. While the ceramic finish is easy to clean, it is fiddly to take apart. You will want to clean it once a week to prevent it from becoming slimy, and you must change the filter once a month. Simon Hill

Petkit Eversweet Solo 2 for $45: I love three key features of this fountain: The bowl sits on top of a wireless charging base, so you don’t have to fiddle with cables, it is super easy to clean, and it’s very quiet at around 25 decibels. A flashing light warns you when the water is running low, and you can check when the filter needs to be changed in the app. There’s an optional smart mode that pumps intermittently and a night mode to turn the light off. Pleasingly, all three of our cats drink from this fountain, though that does mean I have to refill it often, as it only holds 2 liters. Simon Hill

Oneisall Stainless Steel Pet Fountain a metallic bowl with circular pan on top where water flows onto from a curved spout

Photograph: Simon Hill

Oneisall Stainless Steel Pet Fountain for $50: This drinking fountain is about as simple as they come. As it’s designed for cats or small dogs, it has a large bowl, but some cats will prefer that. I love the mostly stainless steel construction, as it’s easy to keep clean and less prone to dirt and bacteria buildup. You can even stick parts into the dishwasher to clean. This fountain can also hold up to 7 liters of water, so you don’t have to refill as often. It’s fairly quiet at around 35 decibels, but it gets louder when the water is running low (a red light warns you when it needs a refill). You should clean once a week and rinse the filter. The filter packs are relatively affordable at $15 for a pack of eight, and you need to swap them once a month. Simon Hill

Petlipo Cordless Cat Water Fountain for $57: This all-plastic pet fountain sits on dock for easier tank cleaning and is rechargeable for up to 60 days of cordless power, has a wire-free pump, a large 2.6 liter capacity, and three customizable water flow modes (induction, timer, and continuous flow). The heavy duty filter is encased in a plastic cage and only needs to be replaced every 4 to 5 weeks. I had no issues while using this fountain, but at nearly $60, thats egregiously expensive for being made out of cheap (and bacteria-harboring) plastic. Although it’s a solid fountain, I’d spend less and grab one of stainless steel picks.

Not Recommended

9 Best Cat Water Fountains WIRED Tested and Reviewed

Photograph: Molly Higgins

Petcube Ceramic Pet Water Fountain for $90: I really wanted to love this fountain; although its basin is plastic, it had a ceramic top, which is more hygienic than plastic (and I had never tested a ceramic model before), and the brand makes some of my favorite pet cameras. However, setup was a bit confusing, it took a long time to get the base charged to power the fountain’s water flow, and the sensor to begin water flow is only triggered from one side, making placement awkward. After a few days, it would only run while plugged in, soon its stream was barely strong enough to reach the top, and after just over a week it stopped working altogether. Also, it’s egregiously expensive for a pet fountain.

Cat Mate a 3level water fountain for pets with two levels for water to cascade down leading into a rectangular reservoir...

Photograph: Molly Higgins

Cat Mate 3-Level Pet Fountain for $28: This tall automatic Cat Mate fountain sets itself apart with three tiers for cats who like to drink at every level. Cleaning the motor requires disassembly using tools and extended soaking. Because of the long distance the water has to travel, evaporation caused the water to need to be refilled about every other day. Plastic also harbors bacteria, and previous plastic models I’ve owned have had mold issues. The basin is quite large and sits flat. Because of this, some debris would sit in the bottom and front of the large basin rather than moving back to the filter system behind. The plastic material and lack of ergonomic gravity design caused this fountain to be dirtier than others.

Whisker City Free Fall Cat Fountain for $30: This huge fountain is better suited for dogs—with a large 150-fluid-ounce bowl and a waterfall design. Although the basin has a small splash pad to help offset the waterfall noise, this was one of the loudest fountains I tested. The evaporation from the waterfall-like system also caused me to refill it every other day. Because of the structure of the fountain, my cats had to bend their head at an awkward angle. They tended to avoid drinking from the basin because of that, and their heads got slightly wet from the splatter of the waterfall. The basin is also not angled so crumbs and debris sit at the bottom of the bowl.

Petkit EverSweet Solo SE for $26: This very simple, straightforward fountain has a square-shaped body, is translucent to easily see water levels from he outside, and has a nearly silent 25-decibel cordless pump to circulate water from the basin to the top level, where 60 milliliters of water is always available for drinking, even in case of power failure. The basin sits on a base and all parts easily detach, making it easier to clean. This fountain doesn’t have multiple modes or an associated app—you’ll have to check water levels manually. I noticed this fountain wasn’t as cold as some of the others, and because of the design of the top, debris often pooled in the dipped areas, which made me clean it often.

I used each of these for a week as my cats’ main source of water. As mentioned, I noted the ease of setting up, evaluated parts and filters, and generally compared the various types of water fountains—spigot, bubbling, or waterfall. Some flows were continuous and some were intermittent (my cats didn’t prefer intermittent). Cats may also be intrigued and want to play with the machine rather than drink, so be sure to give them time and keep another water source around until they are fully adjusted to the new gadget.

Cats sometimes struggle to consume enough water, which can lead to potentially lethal UTIs and blockages in male cats especially. This is one of the reasons vets are moving more toward encouraging owners to give their cat at least a partially wet food diet, as this helps them consume more moisture, especially since cats don’t naturally consume as much water as dogs. Unlike dogs, cats are generally quite particular in their likes and dislikes, and cats can see stagnant water as potentially harmful. (If the cat was in the wild, stagnant water has more potential for harmful bacteria). Cats are more drawn to moving water in nature, and these fountains help encourage them to drink more by emulating what they’re naturally drawn to.

While automatic water fountains are better for your cats’ overall water consumption, they do require a bit more work and money. Rather than refilling a bowl, these take a little more elbow grease—but it’s worth it for your cat’s health. Along with routine refilling and cleaning, you’ll need to disassemble the fountain to clean all parts, including using a brush for the bowl and tubes. You may also have to disassemble the motor to deep-clean because of mineral buildup. These also have different types of filtration cartridges in specific shapes for the brand’s fountains, which require you to buy and change out filters, usually monthly but sometimes more often.

Let’s be honest, a lot of these fountains are pretty much the same. I looked especially for the overall design—I am a fiend for stainless steel because of the potential of porous plastic harboring harmful bacteria. I also favor a wide reservoir without high sides to help reduce the chance for whisker fatigue. I prefer fountains that have a small basin reservoir of water available at all times, in case of low water levels or power failure. I took into account ease of setting up, refilling, and cleaning, as well as overall design. And of course, there were some that my cats took to straight away, and some they didn’t seem to favor as much.

After prolonged testing, I now look for these three things and encourage you too as well: a cordless pump for easier (and safer) cleaning, constructed from stainless steel so it’s more hygienic, and a window to monitor water levels (especially if it’s not connected to an app).

Power up with unlimited access to WIRED. Get best-in-class reporting and exclusive subscriber content that’s too important to ignore. Subscribe Today.



Source link

Continue Reading

Tech

Want to Start a Website? These Are the Best Website Builders

Published

on

Want to Start a Website? These Are the Best Website Builders


Top Website Builders

Best for Most People

Squarespace Core

Read More

Best Cheap Website Builder

Hostinger Website Builder

Read More

Best for Small Business

Strikingly Core

Read More

Best Free Website Builder

Strikingly Website Builder

Read More

Publishing a website is still more complicated than it has any right to be, but the best website builders streamline the process. Instead of juggling a bunch of files on a server and learning the ins and outs of networking, website builders do exactly what’s written on the tin. Piece by piece, using a drag-and-drop interface, you can design your website the way you want with immediate feedback, rather than spending time buried in code and hoping it comes out on the other end.

There are dozens of website builders, and most of them range from decent to straight-up bad. Any web host with a bit of ambition has a website builder floating around, even if it’s slow, clunky, and lacking features. I focused on finding the best tools for building your website that go beyond just an add-on, and these are my favorites. If you’re after something simpler than a full-blown website, check out our list of the Best Portfolio Websites.

Table of Contents

Best Website Builder for Most

Squarespace via Jacob Roach

You’ve heard of Squarespace over and over again, I’m sure, and that’s not an accident. It’s an inviting website builder that made a name for itself with bold, striking templates. Beneath the veneer of attractive, but seemingly simple, websites, you’ll find one of the most capable website builders on the market. That balance of power and usability is what sets Squarespace apart.

It feels like a creative tool. Where other website builders lag and stutter to get a new element on your page, Squarespace feels fluid. Your dashboard gives you quick access to edit your site, and around every corner, Squarespace feels designed so you never have to look up a tutorial. I started a simple photography website, and within an hour, I had a custom course page set up, an appointment schedule with automated confirmation emails, and services (with pricing and the ability to accept payments) configured.

Squarespace isn’t cheap, but it also doesn’t meddle in restrictive, low-cost plans. Even on the Basic plan, you have access to ecommerce tools and space for multiple contributors.

Squarespace Pricing and Plans

Best Cheap Website Builder

Hostinger via Jacob Roach

Hostinger is better known as a web hosting provider, but it has a surprisingly robust website builder that you can use on its own or for free as part of a hosting package. You don’t get the same world-class template design and dense feature-set of a more expensive builder like Squarespace, but that’s OK. Hostinger’s website builder will run you just a few bucks a month, and based on my testing, it feels heavily angled toward newcomers.

You sacrifice some power for convenience, but there’s an awful lot you can accomplish with Hostinger. Integrations with PayPal, Stripe, and Square allow you to quickly set up e-commerce. Add-ons with WhatsApp give you live chat capabilities, and Printful support means you can sell print-on-demand merchandise. And, if you outgrow the website builder, Hostinger allows you to export your website’s content to WordPress.

Where Hostinger wins for me is through its AI tools. Just about every website builder these days has AI integrated in some way, but it’s around every corner at Hostinger. You need to pay extra for some of these AI features—the logo generator, for example, requires credits—but they give you a great starting point for mocking up the look, feel, and tone of your website.

Hostinger Pricing and Plans

Best for Small Businesses

Wix via Jacob Roach

Wix is undoubtedly the biggest competitor to Squarespace, and I had a hard time putting one above the other. Ultimately, Wix ended up in the backseat due to higher prices and a slightly less intuitive interface. That’s partly because of how powerful Wix is. Rather than corral you in an elegant (if restrictive) website-building workflow, Wix gives you a ton of options.

First, templates. You get a few hundred elsewhere, but Wix offers over 2,000 templates. At the time of writing, there are 223 pages of them on Wix’s website. They aren’t all winners, but I was able to mock up a quick photography portfolio website within a few minutes by browsing the templates and uploading a few photos.



Source link

Continue Reading

Tech

A New Algorithm Makes It Faster to Find the Shortest Paths

Published

on

A New Algorithm Makes It Faster to Find the Shortest Paths


The original version of this story appeared in Quanta Magazine.

If you want to solve a tricky problem, it often helps to get organized. You might, for example, break the problem into pieces and tackle the easiest pieces first. But this kind of sorting has a cost. You may end up spending too much time putting the pieces in order.

This dilemma is especially relevant to one of the most iconic problems in computer science: finding the shortest path from a specific starting point in a network to every other point. It’s like a souped-up version of a problem you need to solve each time you move: learning the best route from your new home to work, the gym, and the supermarket.

“Shortest paths is a beautiful problem that anyone in the world can relate to,” said Mikkel Thorup, a computer scientist at the University of Copenhagen.

Intuitively, it should be easiest to find the shortest path to nearby destinations. So if you want to design the fastest possible algorithm for the shortest-paths problem, it seems reasonable to start by finding the closest point, then the next-closest, and so on. But to do that, you need to repeatedly figure out which point is closest. You’ll sort the points by distance as you go. There’s a fundamental speed limit for any algorithm that follows this approach: You can’t go any faster than the time it takes to sort.

Forty years ago, researchers designing shortest-paths algorithms ran up against this “sorting barrier.” Now, a team of researchers has devised a new algorithm that breaks it. It doesn’t sort, and it runs faster than any algorithm that does.

“The authors were audacious in thinking they could break this barrier,” said Robert Tarjan, a computer scientist at Princeton University. “It’s an amazing result.”

The Frontier of Knowledge

To analyze the shortest-paths problem mathematically, researchers use the language of graphs—networks of points, or nodes, connected by lines. Each link between nodes is labeled with a number called its weight, which can represent the length of that segment or the time needed to traverse it. There are usually many routes between any two nodes, and the shortest is the one whose weights add up to the smallest number. Given a graph and a specific “source” node, an algorithm’s goal is to find the shortest path to every other node.

The most famous shortest-paths algorithm, devised by the pioneering computer scientist Edsger Dijkstra in 1956, starts at the source and works outward step by step. It’s an effective approach, because knowing the shortest path to nearby nodes can help you find the shortest paths to more distant ones. But because the end result is a sorted list of shortest paths, the sorting barrier sets a fundamental limit on how fast the algorithm can run.



Source link

Continue Reading

Trending