Tech
Artificial intelligence can better predict future risk for heart attack patients
A landmark study led by University experts has shown that artificial intelligence can better predict how doctors should treat patients following a heart attack.
The study, conducted by an international team of researchers, led by the University of Leicester’s Honorary fellow, Doctor Florian Wenzl working closely with Professor David Adlam, both from the Department of Cardiovascular Sciences, has been published in The Lancet Digital Health.
Doctors caring for patients with the most common form of heart attack caused by a partial blockage, known as non-ST-elevation acute coronary syndrome (NSTE-ACS)—typically rely on the GRACE score to estimate a patient’s risk of dying or having another cardiovascular event. It is used to guide treatment decisions but has long been recognized as being unable to capture the full complexity of each patient.
However, the newly created GRACE 3.0 score is an advanced, AI-based risk assessment tool for patients with acute coronary syndromes. It is able to predict the probability of in-hospital and 1-year mortality by looking at nine widely available variables: age, sex, heart rate, systolic blood pressure, troponin level, ST-deviation, creatinine level, cardiac arrest, and heart failure symptoms.
Dr. Wenzl said, “GRACE 3.0 represents the next evolution of the GRACE score, bringing AI methods into one of the most widely used risk tools in cardiology. It was trained and externally validated on data from hundreds of thousands of patients from multiple countries, which gives it a very strong evidence base. Unlike traditional risk scores, GRACE 3.0 captures complex and non-linear relationships that conventional approaches often miss.”
“Another key improvement is that GRACE 3.0 is sex-specific and tailored precisely for patients with a partial blockage in their coronary artery, rather than being applied more broadly across those with other types of heart attacks caused by complete blockage in their coronary artery.
“In addition, the GRACE 3.0 score enables physicians to better predict whether or not patients will benefit from early invasive treatment such as angioplasty (to open the artery with a balloon and typically place a stent).”
Professor Adlam, an interventional cardiologist at the University, working within the Leicester NIHR Biomedical Research Center, added, “This newly developed score, using artificial intelligence, helps tailor treatment for patients by better detecting future risk and therefore guiding which health interventions they would benefit from.
“The GRACE 3.0 score is now increasingly being incorporated into international guidelines and may inform the design of future clinical trials.”
More information:
Florian A Wenzl et al, Extension of the GRACE score for non-ST-elevation acute coronary syndrome: a development and validation study in ten countries, The Lancet Digital Health (2025). DOI: 10.1016/j.landig.2025.100907
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Tech
The Best Chromebooks Are Doing Their Best to Course Correct
I was delighted to see that the Acer Chromebook Plus 516 didn’t skimp on a crappy touchpad. That goes a long way toward improving the experiencing of actually using the laptop on a moment-by-moment basis. I wasn’t annoyed every time I had to click-and-drag or select a bit of text. This one’s biggest weakness is definitely the screen, which is true of just about every cheap Chromebook I’ve tested. The colors are ugly and desaturated, giving the whole thing a sickly green tint. It’s also not the sharpest in the world, as it’s stretching 1920 x 1200 pixels across a large, 16-inch screen. But in terms of usability and performance, the Acer Chromebook Plus 516 is a great value, combining an Intel Core i3 processor with 8 GB of RAM and a 128 GB of storage. For a Chromebook that’s often on sale for $350, it’s a steal.
While we’re here, let’s go even cheaper, shall we? Asus has two dirt-cheap Chromebooks that I tested last year that I was mildly impressed by. The Asus Chromebook CX14 and CX15. Notice in the name that these are not “Chromebook Plus” models, meaning they can be configured with less RAM and storage, and even use lower-powered processors. That’s exactly what you get on the cheaper configurations of the CX14 and CX15, which is how you sometimes get prices down to as low as $130. I definitely recommend the version with 8 GB of RAM, but regardless of which you choose, the both the CX14 and larger CX15 are mildly attractive laptops. You’d know that’s a big compliment if you’ve seen just how ugly Chromebooks of this price have been in the past.
With these, though, I appreciate the relatively thin bezels and chassis thickness, as well as the larger touchpad and comfortable keyboard. The CX15 even comes in a striking blue color. The touchpad isn’t great, nor is the display. Like the Acer Chromebook Plus 516, it suffers from poor color reproduction and only goes up to 250 nits of brightness. It only has a 720p webcam too, which makes video calls a bit rough. But that’s going to be true of nearly all the competition (and there isn’t much).
Of the two models, I definitely prefer the CX14 though, as it doesn’t have a numberpad and off-center touchpad, which I’ve always found to be awkward to use. Look—no one’s going to love using a computer that costs the less than $200, but if it’s what you can afford, the Asus Chromebook CX14 will at least get you by without too much frustration.
Whatever you do, don’t just head over to Amazon and buy whatever ancient Chromebook is selling for $100 for your kid. It’s worth the extra cash to get something with better battery life, a more modern look, and decent performance.
Other Good Chromebooks We’ve Tested
We’ve tested dozens and dozens of Chromebooks over the past years, having reviewed every major release across the spectrum of price. Unlike Macs and Windows laptops, Chromebooks tends to stick around a bit longer though, and aren’t refreshed as often. I stand by my picks above, but here are a few standouts from our testing that are still worth buying for the right person.
Photograph: Daniel Thorp-Lancaster
Tech
Interview: Critical local infrastructure is missing link in UK cyber resilience | Computer Weekly
Critical local infrastructure that supports council services, social care services and local transport in the UK is falling through the gaps in government and business planning for cyber resilience, claims Jonathan Lee, director of cyber strategy at cyber security company TrendAI.
In an interview with Computer Weekly, Lee says that municipal areas, such as London or Greater Manchester, could be at risk from multiple cyber attacks that could damage local infrastructure, causing escalating problems for residents that could add up to severe disruption.
“We need to be thinking about what would happen if multiple attacks happened at the same time across the city region – and the human impact of not being able to do your job properly, not being able to travel around and not being able to deliver public services,” he says.
The Cyber Security and Resilience Bill (CSRB), which is currently going through Parliament, aims to ensure that critical national services, such as healthcare, water, transport and energy, are protected against cyber attacks that cost the economy billions of pounds a year. But local infrastructure has been relatively neglected, claims Lee.
The National Cyber Security Centre’s (NCSC) Cyber Assurance Framework, for example, aims to help operators of critical national infrastructure (CNI) demonstrate a base level of cyber security preparedness – but it is not mandatory, and not every organisation that should implement it is implementing it.
Whole of society risk
“We need to be more stringent in making sure that people are taking this seriously and are looking not just at their own organisation, but are looking at the whole of society risk,” says Lee.
Attacks on public services, such as council-run social care, can have a catastrophic, knock-on effect on the NHS and patient care, he adds.
There is a need for more “top-down” advice for regional infrastructure providers, from organisations such as the NCSC, which is not as well known as it could be among the companies and public sector bodies that provide local infrastructure.
“The message has got to be diffused down into local levels to ensure that a consistent message is spread out, and that can also be through industry partners. That is something I feel quite strongly about,” says Lee.
The Cyber Essentials programme, which has been updated to include new requirements for organisations to use multifactor authentication (MFA), and requirements for cloud providers to patch vulnerabilities within 14 days, has helped build resilience, but only for organisations that choose to adhere to it.
Keeping the resilience score
The UK government is also intending to publish a Cyber Action Plan in the coming months, which will guide organisations to get basic security right and improve their cyber security over time.
Although there is no shortage of initiatives and action plans, there is a danger that many of these plans will be left on a shelf.
One approach is for organisations to rate themselves on a scorecard for cyber resilience, on a scale of, say, 1 to 100, and to report their progress back to board-level directors.
“We need a mechanism to measure how impactful these interventions are, whether it be things like the Cyber Assessment Framework, Cyber Essentials or legislation,” says Lee.
Tech
Join Our Livestream: Musk v. Altman and the Future of OpenAI
Two of Big Tech’s most influential billionaires, Sam Altman and Elon Musk, will go head-to-head in a highly anticipated trial beginning April 27. In Musk v. Altman, a judge, advised by a jury, will ultimately determine whether OpenAI has strayed from its founding mission to ensure that artificial general intelligence (AGI) benefits humanity, and the ruling could influence how the world’s leading AI developer controls and distributes its technology. For now, you can learn more about the trial here.
On the Panel
On May 8, a panel of WIRED experts will go live to answer your questions about this consequential case.
- Zoë Schiffer: WIRED’s director of business and industry, who oversees coverage of business and Silicon Valley.
- Maxwell Zeff: a senior writer at WIRED covering the business of artificial intelligence. He writes the weekly Model Behavior newsletter, which focuses on the people, communities, and companies behind Silicon Valley’s AI scene.
- Paresh Dave: a senior writer at WIRED covering the inner workings of Big Tech companies. He writes about how apps and gadgets are built and about their impacts while giving voice to the stories of the underappreciated and disadvantaged.
Ask a Question
Submit all your burning questions about this historic legal battle at WIRED’s next, subscriber-only livestream scheduled for May 8 at noon ET / 9 PT. To leave questions in advance as the trial unfolds, head to the comment section below.
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In the meantime, check out past livestreams on Big Tech and the military, the future of electric vehicles, and more.
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